The use of bioimpedance in the detection/screening of tongue cancer.

Abstract:

:Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objectives of this study were therefore to study the electrical properties of cancerous tongue tissue and normal tongue tissue, as well as to investigate a new approach for low-cost, noninvasive, and real-time screening of oral cancer. Twelve tongue cancer patients and twelve healthy subjects participated in this study. A disposable probe with four silver electrodes was used to measure the electrical properties of patient's and healthy subject's tongue tissues at six different frequencies, which were 20Hz, 50kHz, 1.3MHz, 2.5MHz, 3.7MHz and 5MHz. The amplitude of the applied voltage was limited to 200mV. Four measurement parameters of impedance, phase angle, real part of impedance, and imaginary part of impedance of tongue were assessed to see if significant difference in values obtained in patient's and healthy subject's tongue tissues existed. Intraclass correlation coefficient showed that all measurements had good reliability and validity (ICC>0.95 for all measurements). Significant differences were found at 20Hz (p<0.05-0.001 for the four measurement parameters) and 50kHz (p<0.001 for the four measurement parameters) between patient's and healthy subject's tongue tissues. In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.

journal_name

Cancer Epidemiol

journal_title

Cancer epidemiology

authors

Sun TP,Ching CT,Cheng CS,Huang SH,Chen YJ,Hsiao CS,Chang CH,Huang SY,Shieh HL,Liu WH,Liu CM,Chen CY

doi

10.1016/j.canep.2009.12.017

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

207-11

issue

2

eissn

1877-7821

issn

1877-783X

pii

S1877-7821(10)00002-0

journal_volume

34

pub_type

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