Abstract：
AIM:Several studies indicate that use of hormone replacement therapy (HRT) is associated with an increased risk of intracranial meningioma, while associations between HRT use and risk of other brain tumors have been less explored. We investigated the influence of HRT use on the risk of glioma in a nationwide setting. METHODS:Using population-based registries we conducted a case-control study nested in the Danish female population. We identified all women aged 55-84 years with a first diagnosis of histologically verified brain glioma during 2000-2009. Using risk-set sampling, each case was matched on birth year to eight population controls. Ever use of HRT was defined as ≥2 HRT prescriptions and categorized according to type (oestrogens only, combined oestrogen-progestagen and progestagen only) and duration of use (<1, ≥1 to <5, ≥5 to <10, and ≥10 years). We used conditional logistic regression to compute odds ratios (ORs), with 95% confidence intervals (CIs), for glioma associated with HRT use, adjusting for potential confounders. RESULTS:We identified 658 cases and 4350 controls. Ever use of HRT was associated with an OR of 0.9 (95% CI: 0.8-1.1) for glioma. For long-term use (≥10 years) we found ORs of 1.1 (95% CI: 0.7-1.7) for HRT overall, 1.6 (95% CI: 0.9-2.6) for oestrogen only, 0.8 (0.4-1.6) for combined oestrogen-progestagen, and 2.2 (0.9-5.5) for progestagen. Tests for trends were statistically non-significant in all strata. CONCLUSION:Use of HRT overall was not associated with an increased risk of glioma. However, our findings indicate that prolonged use of oestrogen only or progestagen may be associated with an increased risk of glioma.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Andersen L,Friis S,Hallas J,Ravn P,Gaist Ddoi
10.1016/j.canep.2013.09.017subject
Has Abstractpub_date
2013-12-01 00:00:00pages
876-80issue
6eissn
1877-7821issn
1877-783Xpii
S1877-7821(13)00159-8journal_volume
37pub_type
杂志文章abstract：BACKGROUND:Breast cancer has the highest incidence in women of all cancers and its burden is expected to continue to increase worldwide, especially in middle-income countries such as Thailand. The southern region of Thailand is unique in that it is comprised of 30% Muslims, whereas the rest of Thailand is 95% Buddhist....
journal_title：Cancer epidemiology
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更新日期：2017-08-01 00:00:00
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.canep.2013.07.008
更新日期：2013-12-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The potentially functional polymorphism, rs909253 (+252 G>A), in the intron region of the LT-α (TNF-β) gene has been implicated in the risk of gastric cancer (GC) in some individually published studies, but others have shown inconsistent and inconclusive results. METHODS:We conducted a meta-analysis to asse...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
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更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Diabetes and metabolic syndrome have been found to increase the risk of various cancers. Previous studies indicated that diabetes may increase the risk of head and neck squamous cell carcinoma (HNSCC). Metabolic syndrome has not been investigated as a risk factor. We tested whether type II diabetes or metabo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Antigenic stimulation is a proposed aetiologic mechanism for many haematological malignancies. Limited evidence suggests that community-acquired infections may increase the risk of acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). However, associations with other myeloid malignancies includ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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abstract：BACKGROUND:Age-standardization is vital in international comparison studies of cancer patient survival, but standard approaches can fail to produce estimates in the case of sparsity. METHODS:The purpose of this paper is to demonstrate that using a standardization pre-weighting approach is a viable alternative approach...
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pub_type： 杂志文章
doi：10.1016/j.canep.2020.101745
更新日期：2020-08-01 00:00:00
