Abstract:
BACKGROUND AND AIM:SOX6, a member of the D subfamily of sex determining region y-related transcription factors, plays critical roles in cell fate determination, differentiation and proliferation. It has been identified as a tumor suppressor or an oncogene in different human cancers. However, the role of SOX6 in the development and progression of hepatocellular carcinoma (HCC) has not been explored. The aim of this study was to investigate the expression of SOX6 in HCC and determine its correlation with tumor progression and prognosis. METHODS:130 HCC patients who had undergone curative liver resection were selected and immunohistochemistry, Western blotting, and quantitative real time polymerase chain reaction (Q-PCR) were performed to analyze SOX6 expression in the respective tumors. RESULTS:Q-PCR, immunohistochemistry and Western blotting consistently confirmed the decreased expression of SOX6 at both mRNA and protein levels in HCC tissues compared with their adjacent nonneoplastic tissues (P<0.01). Additionally, the expression of SOX6, determined by immunohistochemistry, was negatively correlated with the tumor stage (P=0.003) and serum AFP (P=0.02). Moreover, HCC patients with lower SOX6 expression had worse 5-year disease-free survival and 5-year overall survival than those with high SOX6 expression (P=0.006 and 0.001, respectively). Furthermore, the Cox proportional hazards model showed that the decreased expression of SOX6 was an independent poor prognostic factor for both 5-year disease-free survival (hazards ratio [HR]=2.398, 95% confidence interval [CI]=1.601-5.993, P=0.01) and 5-year overall survival (HR=3.569, CI=1.381-7.290, P=0.008) in HCC. CONCLUSION:These findings provide evidence for the first time that SOX6 expression was decreased in HCC, which correlated with poor prognosis, suggesting that SOX6 may be a novel and potential prognostic marker for HCC.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Guo X,Yang M,Gu H,Zhao J,Zou Ldoi
10.1016/j.canep.2013.05.002subject
Has Abstractpub_date
2013-10-01 00:00:00pages
732-6issue
5eissn
1877-7821issn
1877-783Xpii
S1877-7821(13)00078-7journal_volume
37pub_type
杂志文章abstract:BACKGROUND:This study examined the incidence of skeletal-related events (SRE) among patients with breast cancer (BC)- or prostate cancer (PC)-induced bone metastasis or multiple myeloma (MM) based on a population-based, 12-year healthcare database. METHODS:Patients aged ≥18 years with bone metastasis from BC or PC or ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2019.05.013
更新日期:2019-08-01 00:00:00
abstract::Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the adult population at high risk of developing lung cancer in the EU in 2014. Methods This is a cross-sectional study. We...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.10.007
更新日期:2018-12-01 00:00:00
abstract::This study was aimed to analyze the spectrum of time intervals, from the onset of symptoms to the commencement of treatment in esophagogastric cancers. Factors influencing these time delays and correlation between these time points with variables including socioeconomic strata, educational level, histopathology, locat...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101770
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Diabetes and metabolic syndrome have been found to increase the risk of various cancers. Previous studies indicated that diabetes may increase the risk of head and neck squamous cell carcinoma (HNSCC). Metabolic syndrome has not been investigated as a risk factor. We tested whether type II diabetes or metabo...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2013.03.006
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:This paper aims to determine whether racial disparities exist in hospitalization outcomes among African-American and White hospitalized prostate cancer patients in the United States. We evaluated racial differences among matched groups of patients in post-operative complications, hospital length of stay and ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2016.12.001
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:In cancer care, the cure proportion (P) and time-to-cure (TTC) are important indicators for practitioners, patients, and healthcare policy makers. The recent definition of TTC as the time at which the probability of belonging to the cured group reaches 95% was used for the first time. METHODS:The data stem ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2019.02.006
更新日期:2019-06-01 00:00:00
abstract:INTRODUCTION:Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. OBJECTIVES:Investigate the association of caesarean sections, pre- and po...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101851
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 2005 and 2014. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2016.07.018
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Matrix metalloproteinase-7 (MMP-7) is a member of the family of matrix metalloproteinases (MMPs); it is associated with invasive tumor growth and distant metastasis in colorectal cancer (CRC). However, the prognostic value of MMP-7 in CRC remains controversial. Thus, we conducted a meta-analysis to investigat...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.canep.2015.01.009
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Although, biologically plausible evidence has implicated coffee, tea and caffeine with carcinogenesis, there is a paucity of data on their associations with risk of cancer among Canadian women. Hence, we assessed their associations with risk of breast, endometrial and ovarian cancers within this population. ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2018.07.013
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Obesity and diabetes have been associated with liver cancer. However, recent US-based studies have suggested a lack of association between obesity and liver cancer among blacks and women. METHODS:We conducted a nested case-control study within the Multiphasic Health Checkup (MHC) cohort of Kaiser Permanente ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2016.04.009
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:The effect of inequalities aggravated by economic recessions in the mortality rates of certain diseases has been previously described. In this study, we analyzed the relationship between socio-economic deprivation and cancer mortality. We focused on lung, colon, prostate, and breast cancers in nine European ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101827
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Obesity is a well-established risk factor for postmenopausal breast cancer, but mechanisms underlying the association are unclear. Adipocyte-derived, cytokine-like adipokines have been suggested as contributory factors. To evaluate their association with breast cancer risk factors and breast cancer risk, w...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.05.014
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) metastasis occurs in various organs, most frequently in liver. Serological examination including tumor and biochemical markers for liver function evaluation is routinely performed, though its accuracy is not high. MicroRNAs (miRNAs) have been implicated in a variety of human diseases ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.05.002
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Although the incidence of small intestinal adenocarcinoma (SIA) is low, rates are increasing and little information regarding modifiable lifestyle risk factors is available. AIM:To provide a systematic review of lifestyle factors and SIA risk. METHODS:Ovid MEDLINE, EMBASE and Web of science were searched f...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.canep.2015.02.001
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical value in detecting occult primary tumors with (18)F-FDG PET-CT whole body imaging. METHODS:120 patients with unknown primary origin were referred for (18)F-FDG PET-CT whole body imaging. All patients were performed (18)F-FDG PET-CT whole body scan. PET-CT images were interpreted b...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2012.03.002
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Chewing areca (betel) nut has been deemed carcinogenic. The practice has become a public health concern in Micronesia. The Children's Healthy Living (CHL) Program included an areca (betel) nut questionnaire in a survey of household characteristics in the Freely Associated States (FAS). This paper describes a...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.07.009
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:New therapeutic options have led to substantial increases in survival expectations of patients with non-Hodgkin lymphoma (NHL) in recent years. In contrast to many malignancies, survival in older patients has improved in NHL at a rate similar to that in younger patients. In the past, the impact of innovation...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.08.006
更新日期:2012-02-01 00:00:00
abstract::The three times higher incidence of thyroid cancer in women compared to men points to a role of female sex hormones in its etiology. However the effects of these factors are poorly understood. We analyzed the association between thyroid cancer and hormonal and reproductive factors among women enrolled in CATHY, a popu...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.04.001
更新日期:2017-06-01 00:00:00
abstract:AIM:To review and summarize evidence from longitudinal studies on the association between serum 25-hydroxyvitamin D (25(OH)D) and the risk of prostate cancer (PC). METHODS:Relevant prospective cohort studies and nested case-control studies published until July 2009 were identified by systematically searching Ovid Medl...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.canep.2009.10.014
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:This study is part of a national plan of epidemiological surveillance of malignant mesothelioma (MM) mortality in Italy. The paper shows the results of malignant peritoneal mesothelioma (MPeM) mortality study in Italian Regions and municipalities. METHODS:National Bureau of Statistics data for MPeM municipa...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2019.04.001
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To present methodological issues that can arise with the assessment of the risk of a second primary cancer (SPC) occurring in the same site as a first cancer using registry data. MATERIAL AND METHODS:Data from ten French cancer registries were used, including data for patients with a first prostate cancer (i...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.10.004
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Data from the Surveillance, Epidemiology, and End Results (SEER) revealed that the incidence of pediatric cancer in Nebraska exceeded the national average during 2009-2013. Further investigation could help understand these patterns. METHODS:This retrospective cohort study investigated pediatric cancer (0-19...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.12.006
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The disparity in breast cancer mortality rates among white and black US women is widening, with higher mortality rates among black women. We apply functional time series models on age-specific breast cancer mortality rates for each group of women, and forecast their mortality curves using exponential smoothi...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.05.001
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Based the important role of patient-reported outcome in measuring patients' QoL, a general PRO instrument was designed for Chinese patients with cancer. METHODS:The instrument was administered in eight hospitals. Based on PRO guidelines, a conceptual framework and item pool were generated after literature r...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101774
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. METHODS:Breast carcinoma tissues (n=117) and available paired normal breast tissues (n=65) from Tunisian women who had no family history were ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.09.001
更新日期:2012-04-01 00:00:00
abstract::Cadmium, a human carcinogenic heavy metal, has been reported to be associated with breast cancer risk; however, the results from the epidemiological studies are not always consistent. The objective of this study was to quantitatively summarize the current evidence for the relationship between cadmium exposure and brea...
journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.canep.2016.04.002
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:DNA repair gene polymorphisms can contribute to susceptibility of human cancer, including gastric cancer. Three single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum group D (XPD) and X-ray repair cross complement 1 (XRCC1) genes were genotyped in gastric cancer and control subjects in a population...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2010.08.008
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Provider recommendation for colorectal cancer (CRC) screening test has been shown as a strong predictor of patients' decision to be screened. Evidence of factors associated with provider recommendation remains limited and inconsistent. The present study sought to examine the association between provider reco...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2009.07.011
更新日期:2009-10-01 00:00:00
abstract::High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ...
journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2020.101707
更新日期:2020-06-01 00:00:00