Abstract：
:The three times higher incidence of thyroid cancer in women compared to men points to a role of female sex hormones in its etiology. However the effects of these factors are poorly understood. We analyzed the association between thyroid cancer and hormonal and reproductive factors among women enrolled in CATHY, a population-based case-control study conducted in France. The study included 430 cases of papillary thyroid cancer and 505 controls frequency-matched on age and area of residence. The odds ratios for thyroid cancer increased with age at menarche (p trend 0.05). Postmenopausal women were at increased risk, as compared to premenopausal women, particularly if menopause followed an ovariectomy, and for women with age at menopause <55years. In addition, use of oral contraceptives and menopausal hormone therapy reduced the association with thyroid cancer by about one third, and breastfeeding by 27%. Overall, these findings provide evidence that the risk of thyroid cancer increases with later age at menarche and after menopause, and decreases with use of oral contraceptives and menopausal hormone therapy. These findings confirm an implication of hormonal factors in papillary thyroid cancer risk, whose mechanisms need to be elucidated.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Cordina-Duverger E,Leux C,Neri M,Tcheandjieu C,Guizard AV,Schvartz C,Truong T,Guénel Pdoi
10.1016/j.canep.2017.04.001subject
Has Abstractpub_date
2017-06-01 00:00:00pages
78-84eissn
1877-7821issn
1877-783Xpii
S1877-7821(17)30047-4journal_volume
48pub_type
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