Abstract：
:The miR-451 was found to be frequently down-regulated in tumors, indicating that miR-451 could play an important role in carcinogenesis. This study uncovered the mechanism by which the miR-451 functions as a tumor suppressor. The target genes of miR-451 were determined using target gene prediction softwares. Then the miR-451 mimics were introduced into RKO and Hela cells respectively. The proliferation and invasion of cells were monitored by MTT, cell cycle and in vitro extracellular matrix invasion assays. Also the angiogenesis of HUVEC cells transfected with miR-451 mimics was examined. Subsequently, IL6R, a predicted target gene of miR-451, was studied by real time PCR, Western blotting, and siRNA technologies. The mRNA and protein levels of IL6R gene were found to be down-regulated in the RKO and Hela cells transfected with miR-451 mimics. Consequently, the cell proliferation was inhibited. Also, the invasion of RKO cells was suppressed. Furthermore, the angiogenesis of HUVEC cells transfected with miR-451 mimics was assayed and the decreased angiogenic ability was detected compared to the controls. All these results were validated by IL6R siRNA experiments. The IL6R gene is a target gene of miR-451. The miR-451 behaves as a tumor suppressor, probably by targeting the IL6R pathway.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Liu D,Liu C,Wang X,Ingvarsson S,Chen Hdoi
10.1016/j.canep.2013.12.005subject
Has Abstractpub_date
2014-02-01 00:00:00pages
85-92issue
1eissn
1877-7821issn
1877-783Xpii
S1877-7821(13)00191-4journal_volume
38pub_type
杂志文章abstract：BACKGROUND:The potentially functional polymorphism, rs909253 (+252 G>A), in the intron region of the LT-α (TNF-β) gene has been implicated in the risk of gastric cancer (GC) in some individually published studies, but others have shown inconsistent and inconclusive results. METHODS:We conducted a meta-analysis to asse...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2012.05.014
更新日期：2012-12-01 00:00:00
abstract：:High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101707
更新日期：2020-06-01 00:00:00
abstract：:CDKN2A is the most common, most penetrant gene whom germline mutations predisposing to cutaneous familial melanoma (FAM). Multiple primary melanoma (MPM), early age at onset, >2 affected members and pancreatic cancer are consistent features predicting positive test. However, the impact that cumulative clinical feature...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.07.007
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens. The antioxidant response element (ARE...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2010.06.012
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific lung cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for the 5-year intervals 1990-1994 and 2005-2009. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files wh...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Diabetes and metabolic syndrome have been found to increase the risk of various cancers. Previous studies indicated that diabetes may increase the risk of head and neck squamous cell carcinoma (HNSCC). Metabolic syndrome has not been investigated as a risk factor. We tested whether type II diabetes or metabo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.03.006
更新日期：2013-08-01 00:00:00
abstract：:The three times higher incidence of thyroid cancer in women compared to men points to a role of female sex hormones in its etiology. However the effects of these factors are poorly understood. We analyzed the association between thyroid cancer and hormonal and reproductive factors among women enrolled in CATHY, a popu...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.04.001
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:We assessed the association between diabetes and breast cancer and whether physical activity modified the effect of diabetes on breast cancer in Hispanic women. METHODS:We used data from a case-control study of breast cancer among Hispanic women aged 30-79 conducted between 2003 and 2008 on the Texas-Mexico bo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.06.001
更新日期：2010-10-01 00:00:00
abstract：:Association of epigenetic modifications with cancer has been widely studied. Gene-specific hypermethylation and global DNA hypomethylation are the most frequently observed patterns in great number of tumors. The methionine synthase (MTR) gene plays key role in maintaining adequate intracellular folate, methionine and ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.11.002
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Previous studies have reported inconsistent results regarding the effect of epidermal growth factor receptor (EGFR) mutations on overall survival in patients with non-squamous non-small-cell lung cancer (NSCLC). This study assesses the effect of EGFR mutation on overall survival, and how the effects of other...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101847
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Cutaneous malignant melanoma is a major public health issue in Australia and other nations. A greater understanding of the genetic determinants and their interactions with environmental factors may lead to better interventions and control of the disease. The Western Australian Melanoma Health Study (WAMHS) i...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.02.010
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Obesity and diabetes have been associated with liver cancer. However, recent US-based studies have suggested a lack of association between obesity and liver cancer among blacks and women. METHODS:We conducted a nested case-control study within the Multiphasic Health Checkup (MHC) cohort of Kaiser Permanente ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.04.009
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The French national screening programme for colorectal cancer (CRC) was rolled out nationwide from 2008. It targets men and women aged 50-74 who are invited every 2 years to perform a guaiac faecal occult blood test, followed, if positive, by a colonoscopy. This paper presents the evaluation of the programme...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.07.008
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:This study aimed to investigate the association between physical activity and site-specific cancer incidence. METHODS:UK Biobank is a prospective population-based cohort study. 364,899 adults (51.6 % females, mean age 56.0 years) were included. The exposure variable was physical activity level derived from ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101780
更新日期：2020-10-01 00:00:00
abstract：:Several risk factors for colorectal cancer (CRC) have been identified. If individuals with risk factors are more likely to harbor cancer or it precursors screening programs should be targeted toward this population. We evaluated the predictive value of colorectal cancer risk factors for the detection of advanced color...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.02.004
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:In Lebanon, annual national breast awareness campaigns were started in 2002 during the international breast month of October to promote the utilization of mammography for women aged ≥ 40. The impact of the campaigns has been assessed periodically since 2003. Results of 2003-2005 campaigns have been publish...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.09.015
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Recent years have seen increased interest in the role of neighborhood factors in chronic diseases such as cancers. Less is known about the role of neighborhood factors beyond individual demographics such as age or education. It is particularly important to examine neighborhood effects on health among African...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.101666
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The effect of inequalities aggravated by economic recessions in the mortality rates of certain diseases has been previously described. In this study, we analyzed the relationship between socio-economic deprivation and cancer mortality. We focused on lung, colon, prostate, and breast cancers in nine European ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101827
更新日期：2020-12-01 00:00:00
abstract：:Recent studies have identified the important role of cancer stem cells (CSCs) in carcinogenesis and relapse. However, with respect to multistage cancer metastasis, the role of CSCs has not been well-defined. In several human cancers, data showed that some phenotypic subsets of CSCs were responsible for cancer metastas...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.07.007
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION:Receptor status determines of breast cancer treatment and prognosis. In a population-based study, we investigated predictors of receptor test receipt. MATERIALS AND METHODS:Invasive breast cancers diagnosed 2006-2008 were abstracted from the National Cancer Registry Ireland. Modified Poisson regression wi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.08.006
更新日期：2015-10-01 00:00:00
abstract：:The complement system is an important immunosurveillance mechanism against tumors, and complement factor H (CFH) is a key regulator for activation of the complement system. Expression of complement factor H has been demonstrated in cell lines from several malignancies. In this study we examined the contribution of the...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.11.004
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:It is unknown whether a normal range, diagnostic serum prostate specific antigen (PSA) level's influence on prostate cancer specific mortality (PCSM) is dependent upon digital rectal examination (DRE) findings. METHODS:Between 2004 and 2007, 9081 men diagnosed with non-palpable (T1c, N=1710) or palpable (...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.07.007
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy. Treatment with hypomethylating agents (HMA) was introduced between 2004 and 2006 but its impact on population-based survival remains controversial. The aim of this study was to investigate epidemiological characteristics and survival ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.01.003
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Chromosome 19q13.3 has been identified as one of the regions that associate with cancer risk in previous studies. METHODS:We systematically examined the 70.772kb region comprising four genes on chromosome 19q13.3 among Chinese using the haplotype-tagging SNP (htSNP) approach and the HapMap platform. The stu...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2013.09.016
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:The incidence trends of biliary tract cancer need to be established. This study investigated the incidence and mortality of biliary tract cancer in Sweden in 1970-2010. METHODS:Sex-specific biliary tract cancer incidence and mortality rates were evaluated using data from the Swedish Cancer Register, Patient...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.06.004
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to describe survival of lymphoid neoplasms (LNs) in the Girona province (Spain) during 1996-2015. METHODS:Data were extracted from the Girona cancer registry. LN incident cases were registered using the ICD-O-3, following the 2008 WHO classification scheme and HAEMACARE grouping. F...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101841
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:There is a strong evidence for a protective role of physical activity (PA) on cancers of the colon, breast (postmenopausal) and endometrium, but data are less consistent or scarce for other cancer types. This study assessed the relationship between occupational and recreational PA and cancer risk among men i...
journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2010.09.004
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Incidence of childhood cancer increased in most countries worldwide, but reasons are unclear. This study investigates trends of childhood cancer incidence in Switzerland from 1985 to 2014. METHODS:We extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Chil...
journal_title：Cancer epidemiology
pub_type： 历史文章,杂志文章
doi：10.1016/j.canep.2019.06.002
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To investigate the clinical value in detecting occult primary tumors with (18)F-FDG PET-CT whole body imaging. METHODS:120 patients with unknown primary origin were referred for (18)F-FDG PET-CT whole body imaging. All patients were performed (18)F-FDG PET-CT whole body scan. PET-CT images were interpreted b...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2012.03.002
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies have investigated SES differences in tumour stage at...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.canep.2016.01.012
更新日期：2016-04-01 00:00:00
