Abstract：
OBJECTIVE:The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. METHODS:Breast carcinoma tissues (n=117) and available paired normal breast tissues (n=65) from Tunisian women who had no family history were investigated for the methylation status of BRCA1 and BRCA2 promoters using methylation-specific PCR. Breast specimens from women without carcinoma (16 fibroadenomas and 5 mastopathies) were used as control. RESULTS:Hypermethylation of BRCA1 and BRCA2 promoters was detected respectively in 60.7% and 69.2% of the carcinoma tissues, and in only 7.7% and 4.6% of the paired normal breast tissues. None of the fibroadenomas and mastopathies showed hypermethylation. Correlations were found between BRCA1 and BRCA2 hypermethylation and decrease in their mRNA expression (p=0.02 and p=0.009, respectively). Moreover, BRCA1 methylation correlates with patients age (p=0.01) and triple negative (ER-, PR-, HER2-) tumors (p=0.01). Patients with methylated BRCA1 and/or BRCA2 had a significant prolonged survivals compared to those with unmethylated tumors (p=0.002). CONCLUSION:Our results suggest an important role of BRCA1 and BRCA2 promoter methylation in breast cancer development in the Tunisian population.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Ben Gacem R,Hachana M,Ziadi S,Amara K,Ksia F,Mokni M,Trimeche Mdoi
10.1016/j.canep.2011.09.001subject
Has Abstractpub_date
2012-04-01 00:00:00pages
190-7issue
2eissn
1877-7821issn
1877-783Xpii
S1877-7821(11)00129-9journal_volume
36pub_type
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