Abstract：
BACKGROUND:Based the important role of patient-reported outcome in measuring patients' QoL, a general PRO instrument was designed for Chinese patients with cancer. METHODS:The instrument was administered in eight hospitals. Based on PRO guidelines, a conceptual framework and item pool were generated after literature review and patients' interviews. Via two-item selection process, the original version of a cancer PRO measure (CA-PROM) was generated. Patients' responsiveness was evaluated in four disease systems by item response theory. The reliability, validity, and feasibility of CA-PROM were assessed. The minimum clinically important differences (MCIDs) and risk thresholds of PRO were calculated. RESULTS:A total of 2213 valid questionnaires were collected. After expert opinions and cognitive tests, 11 items were deleted. In the pre-survey and formal survey, 19 items were deleted based on six methods of classical test theory. In the respiratory, digestive, hematological, and endocrine systems, four items with poor responsiveness were deleted by item response theory. The final CA-PROM included four domains, 13 subdomains, and 49 items. Reliability coefficients of 13 subdomain was > 0.7. The framework of CA-PROM met required criteria by CFA and OBID. The average response time was 14.2 min, indicating feasibility of CA-PROM. The MCIDs were 5.63, 3.42, 4.16 in the physiological, psychological, social domain, respectively. The risk thresholds of PRO for six subdomains were 71.74, 71.28, 66.29, 65.16, 59.56, 66.60, in that order. CONCLUSION:The developed CA-PROM exhibited good reliability, validity, and feasibility, and can be used as an effective evaluation tool in cancer patients.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Hu X,Zhao Z,Zhang SK,Luo Y,Yu H,Zhang Ydoi
10.1016/j.canep.2020.101774subject
Has Abstractpub_date
2020-08-01 00:00:00pages
101774eissn
1877-7821issn
1877-783Xpii
S1877-7821(20)30108-9journal_volume
67pub_type
杂志文章abstract：BACKGROUND:Immigrant women often have lower cervical cancer screening (CCS) rates, tend to have a higher body mass index (BMI) and may be more vulnerable to BMI-related stigmatization. Our aim was to assess the role of BMI in differences in CCS rates by migration history. METHODS:Analyses were based on the 2012-2015 i...
journal_title：Cancer epidemiology
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更新日期：2015-08-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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