Abstract:
BACKGROUND:Although, biologically plausible evidence has implicated coffee, tea and caffeine with carcinogenesis, there is a paucity of data on their associations with risk of cancer among Canadian women. Hence, we assessed their associations with risk of breast, endometrial and ovarian cancers within this population. METHODS:The study comprised a subcohort of 3185 women from a cohort of 39,532 female participants who completed self-administered lifestyle and dietary questionnaires at enrollment. During a median follow-up of approximately 12.2years, we ascertained 922, 180 and 104 breast, endometrial and ovarian cancer cases, respectively. We used Cox proportional hazards regression models modified for the case-cohort design to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the associations of coffee, tea and caffeine with risk of selected cancers. RESULTS:Coffee, tea, and caffeine intake were not associated with overall risk of breast and ovarian cancers. There was, however, a tendency towards an increased risk of breast cancer with increasing levels of total coffee, caffeinated coffee and/or caffeine among premenopausal and normal weight women. Total coffee, caffeinated coffee, and caffeine were inversely associated with risk of endometrial cancer (HRper cup increase: 0.88; 95% CI: 0.79-0.95, HRper cup increase: 0.88; 95% CI: 0.80-0.96 and HRper 100mg increase: 0.93; 95% CI: 0.87-0.99, respectively). CONCLUSION:Our findings suggest that coffee and/or caffeine may be associated with reduced risk of endometrial cancer but, probably, associated increased with risk of breast cancer among premenopausal or normal weight women. However, further studies are needed to confirm our findings.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Arthur R,Kirsh VA,Rohan TEdoi
10.1016/j.canep.2018.07.013subject
Has Abstractpub_date
2018-10-01 00:00:00pages
75-82eissn
1877-7821issn
1877-783Xpii
S1877-7821(18)30152-8journal_volume
56pub_type
杂志文章abstract:BACKGROUND:Ten genes are associated with increased susceptibility to inherited breast cancer have also been associated with population breast cancer risk, and all are involved directly or indirectly in the monoubiquitinated FANCD2-DNA damage repair pathway. We analyzed 13 haplotype blocks in eight of these genes to est...
journal_title:Cancer epidemiology
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abstract:INTRODUCTION:Folic acid fortification and supplementation to prevent neural tube defects has led to concerns regarding increased risk of colorectal cancer. The results of existing studies have been inconclusive. The purpose was to examine the relationship between level of folate intake and the incidence of colorectal c...
journal_title:Cancer epidemiology
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2011.05.002
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pub_type: 杂志文章
doi:10.1016/j.canep.2013.02.010
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journal_title:Cancer epidemiology
pub_type: 杂志文章
doi:10.1016/j.canep.2017.03.002
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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journal_title:Cancer epidemiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Cancer epidemiology
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Cancer epidemiology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Cancer epidemiology
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