Abstract：
BACKGROUND:The publication of the Women's Health Initiative Study in 2002 spurred reductions in hormone replacement therapy (HRT) use worldwide. Subsequent drops in breast cancer incidence have since been reported. We used person-level data from a large Israeli health plan to study the relationship between HRT use and breast cancer incidence. METHODS:We accessed pharmacy, mammography and cancer registry data for women ages 50 and over. Using Chi-square analysis, we examined changes over time in HRT and mammography utilization and breast cancer incidence [invasive and ductal carcinoma in situ (DCIS)]. Using calendar year-specific Cox proportional hazards analyses, we estimated the hazard of recent HRT use on cancer incidence. We used locally weighted scatterplot smoothing (LOWESS) and autoregressive integrated moving average (ARIMA) modeling to further examine this association. RESULTS:The study population ranged from 118,724 in 2000 to 154,447 in 2007. Thirteen percent of study women purchased HRT in 2000, vs. 4.0% in 2007 (p<0.001). Breast cancer incidence rose from 3.8/1000 to 4.3/1000 in 2005; the proportion of women undergoing mammography rose from 8% in 2000 to a peak of 34.1% in 2005 (p<0.001). Hazard ratios for the association of HRT with breast cancer ranged from 1.2 to 2.4. ARIMA demonstrated the association of both mammography (in the same month) and HRT use (in the preceding month) with cancer incidence. CONCLUSION:This study demonstrates the competing impacts of HRT and mammography on cancer incidence. Our findings support the conclusion that changes in HRT utilization are linked to reductions in breast cancer incidence.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Silverman BG,Siegelmann-Danieli N,Braunstein R,Kokia ESdoi
10.1016/j.canep.2010.11.006subject
Has Abstractpub_date
2011-02-01 00:00:00pages
11-6issue
1eissn
1877-7821issn
1877-783Xpii
S1877-7821(10)00206-7journal_volume
35pub_type
杂志文章abstract：BACKGROUND:The aim of this study was to describe incidence patterns of lymphoid neoplasms in the Girona province (Spain) (1996-2015), and to predict the number of cases in Spain during 2020. METHODS:Data were extracted from the Girona cancer registry. Incident cases were classified using the ICD-O-3, third revision, a...
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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journal_title：Cancer epidemiology
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pub_type： 杂志文章
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journal_title：Cancer epidemiology
pub_type： 杂志文章
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