Abstract：
BACKGROUND:IFN regulatory factor 4-binding protein (IBP) is a novel type of activator of Rho GTPases. It has been linked with differentiation and apoptosis of lymphocytes, but its function in oncogenesis remains unclear. Here we studied the expression of endogenous IBP in four human colorectal cancer cell lines, normal, adenoma and tumor colorectal tissues. METHODS:Molecular (Western blot and RT-PCR), and confocal analyses were used to investigate IBP expression in human colorectal cancer cell lines. Matched normal and tumor tissue sections of 63 patients and 15 adenoma tissue sections were analyzed for IBP expression by immunohistochemistry (IHC). RESULTS:IBP was ubiquitely expressed in human colorectal cancer cell lines. The expression of IBP can be detected at both the mRNA and protein level in SW480, SW620 and HT29 cells. Clinically, IBP were elevated in human colorectal cancer specimens in comparison to normal colorectal tissues. Substantial high expression of IBP was observed in colorectal cancer tissues (67%), whereas corresponding normal tissues and 15 adenoma tissues showed consistently absent immunoreactivity of IBP. Moreover, IBP expression is correlated with the differentiation level of colorectal cancer cells (p<0.05) and clinical stage of patients (p<0.01). CONCLUSIONS:Our data show, for the first time, a dysregulated expression of IBP in human colorectal cancer, offering new perspectives for its role in cancer development and progression. IBP may be a novel tumor marker and a therapeutic target for colorectal cancer.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Zhang Z,Wang Q,Li P,Zhou Y,Li S,Yi W,Chen A,Kong P,Hu Cdoi
10.1016/j.canep.2009.05.004subject
Has Abstractpub_date
2009-08-01 00:00:00pages
130-6issue
2eissn
1877-7821issn
1877-783Xpii
S1877-7821(09)00054-Xjournal_volume
33pub_type
杂志文章abstract：OBJECTIVE:Matrix metalloproteinase-7 (MMP-7) is a member of the family of matrix metalloproteinases (MMPs); it is associated with invasive tumor growth and distant metastasis in colorectal cancer (CRC). However, the prognostic value of MMP-7 in CRC remains controversial. Thus, we conducted a meta-analysis to investigat...
journal_title：Cancer epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.canep.2015.01.009
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Colorectal cancer is a leading cause of death worldwide for men and women, and one of the most commonly diagnosed in Córdoba, Argentina. The aim of this work was to provide an up-to-date approach to descriptive epidemiology of colorectal cancer in Córdoba throughout the estimation of mortality trends in the ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.09.009
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Data from the Surveillance, Epidemiology, and End Results (SEER) revealed that the incidence of pediatric cancer in Nebraska exceeded the national average during 2009-2013. Further investigation could help understand these patterns. METHODS:This retrospective cohort study investigated pediatric cancer (0-19...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.12.006
更新日期：2018-02-01 00:00:00
abstract：INTRODUCTION:Receptor status determines of breast cancer treatment and prognosis. In a population-based study, we investigated predictors of receptor test receipt. MATERIALS AND METHODS:Invasive breast cancers diagnosed 2006-2008 were abstracted from the National Cancer Registry Ireland. Modified Poisson regression wi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.08.006
更新日期：2015-10-01 00:00:00
abstract：:It is estimated that over half the population of the European Union (EU) is overweight or obese due to an imbalance between energy expenditure and energy intake; this is related to an obesogenic environment of sociocultural, economic and marketing challenges to the control of body weight. Excess body fat is associated...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.01.017
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:We investigated cancer incidence and all-cause mortality among 21,582 Norwegian male military peacekeepers deployed to Lebanon during 1978-1998. We also looked at cancer risk according to duration of service in Lebanon, in the occupational groups of cooks and mechanics, and the risk of alcohol- and smoking-re...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.04.011
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:To describe the sex-specific incidence rates and the male-to-female incidence-rate ratios (IRRs) of different cancer types, and to explore the corresponding sex disparities in an area of Eastern China. METHODS:We used data from the Cancer Registry in Jiashan County, and calculated the sex-specific age-standard...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.07.013
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:New therapeutic options have led to substantial increases in survival expectations of patients with non-Hodgkin lymphoma (NHL) in recent years. In contrast to many malignancies, survival in older patients has improved in NHL at a rate similar to that in younger patients. In the past, the impact of innovation...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.08.006
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 2005 and 2014. METHODS:The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.018
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:This study examined the incidence of skeletal-related events (SRE) among patients with breast cancer (BC)- or prostate cancer (PC)-induced bone metastasis or multiple myeloma (MM) based on a population-based, 12-year healthcare database. METHODS:Patients aged ≥18 years with bone metastasis from BC or PC or ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2019.05.013
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Time to treatment of cancer is becoming a serious political and social issue. A greater understanding of the timeframes involved in cancer care is needed to reduce inequalities in access to care caused by delays. OBJECTIVE:To describe indicators of time to first treatment after colonoscopy in colon cancer (...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.002
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:We developed a novel method of methylation-specific PCR (MSP) using immunoprecipitation with anti-histone antibody (IP-MSP) to efficiently detect serum methylated DNA tightly bound to de-acetylated histones. MATERIALS AND METHODS:The detection limit of IP-MSP for p16 methylation was determined with a standa...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.01.004
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:Obesity is a well-established risk factor for postmenopausal breast cancer, but mechanisms underlying the association are unclear. Adipocyte-derived, cytokine-like adipokines have been suggested as contributory factors. To evaluate their association with breast cancer risk factors and breast cancer risk, w...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.05.014
更新日期：2010-10-01 00:00:00
abstract：:South Asian countries are facing a hidden breast cancer epidemic. A significant proportion of the breast cancer cases occur in premenopausal women. Knowledge of the various aspects of breast cancer in different geographical regions is limited in South Asia. In this article, we review the Bangladeshi perspective of the...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2014.08.004
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:This study investigated the role that demographic and tumour factors play in explaining socioeconomic inequalities in breast cancer survival. METHODS:Breast cancer cases notified to the New Zealand Cancer Registry (NZCR) from April 2005 to April 2007 were followed up to April 2009. The New Zealand area-base...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.07.007
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:With linked register and cause of death data becoming more accessible than ever, competing risks methodology is being increasingly used as a way of obtaining "real world" probabilities of death broken down by specific causes. It is important, in terms of the validity of these studies, to have accurate cause ...
journal_title：Cancer epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.canep.2012.08.012
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:The anatomic distribution of advanced colorectal neoplasia is increasingly important for choosing screening strategies and treatment options. We sought to evaluate the impact of repeated screening on the positive predictive value (PPV) for advanced colorectal neoplasia (advanced adenoma, AA, and colorectal c...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.09.008
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:It is unknown whether a normal range, diagnostic serum prostate specific antigen (PSA) level's influence on prostate cancer specific mortality (PCSM) is dependent upon digital rectal examination (DRE) findings. METHODS:Between 2004 and 2007, 9081 men diagnosed with non-palpable (T1c, N=1710) or palpable (...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.07.007
更新日期：2014-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Cancer burden is increasing in Central and South America (CSA). We describe the current burden of cancer in CSA. METHODS:We obtained regional and national-level cancer incidence data from 48 population-based registries (13 countries) and nation-wide cancer mortality data from the WHO (18 countr...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.07.013
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To investigate whether health insurance affiliation and socioeconomic deprivation is associated with overall cause survival from gastric cancer in a middle-income country. METHODS:All patients resident in the Bucaramanga metropolitan area (Colombia) diagnosed with gastric cancer between 2003 and 2009 (n=1039...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2014.10.012
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Barrett's Esophagus (BE), particularly long-segment Barrett's Esophagus, and the age of onset of Barrett's Esophagus are risk factors for esophageal adenocarcinoma. However, it is unknown if lifestyle factors such as alcohol abuse, tobacco use, weight gains that increase the risk of developing BE and esophag...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.10.013
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The burden of renal cell carcinoma (RCC) in young adults received marginal attention. We assessed contemporary gender, race and stage-specific incidence and trends of RCC among young adults (20-39 years-old) in the United States. METHODS:Within Surveillance, Epidemiology, and End Results database (2000-2016...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2020.101762
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND/AIM:This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. METHODS:This test dataset comprised 950 Aboriginal cases and all other cases recor...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2017.04.013
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:Despite the continuous efforts made with the TNM system, the issue of heterogeneity of prognosis within the stages of non-small cell lung cancer (NSCLC) could not be resolved. Our aim was to identify prognostic factors and develop an index to predict NSCLC survival with greater accuracy. METHODS:We conduc...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2018.01.018
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the h...
journal_title：Cancer epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canep.2019.101643
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:We assessed the association between diabetes and breast cancer and whether physical activity modified the effect of diabetes on breast cancer in Hispanic women. METHODS:We used data from a case-control study of breast cancer among Hispanic women aged 30-79 conducted between 2003 and 2008 on the Texas-Mexico bo...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2010.06.001
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Provider recommendation for colorectal cancer (CRC) screening test has been shown as a strong predictor of patients' decision to be screened. Evidence of factors associated with provider recommendation remains limited and inconsistent. The present study sought to examine the association between provider reco...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2009.07.011
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:This report describes the resources required to support the integrated approach of the Barbados National Registry for Chronic Non-communicable Diseases (BNR) to non-communicable disease (NCD) case registration, and to identify differences in cost for collecting and maintaining information on cancer and cardi...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2016.10.020
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Despite being a well-documented phenomenon, seasonal variation in the incidence of cutaneous melanoma is poorly understood, and data on the seasonality of melanoma survival are scarce. We sought to explore the seasonal variation in melanoma incidence and survival in Belgium and to assess the characteristics ...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2015.07.003
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that migrants have lower cancer mortality rates compared to the Australian-born population, particularly for colorectal and breast cancers, which are associated with an affluent lifestyle. This study seeks to update knowledge in this field by examining mortality from colorectal, s...
journal_title：Cancer epidemiology
pub_type： 杂志文章
doi：10.1016/j.canep.2011.10.011
更新日期：2012-04-01 00:00:00
