Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla.

abstract：:Incomplete achromatopsia (ACHM) is a disorder in which there is function defect of cone photoreceptors in the retina and individuals with such disease retain residual color vision. Here, we have generated an induced pluripotent stem cell (iPSC) line carrying a homozygous mutation in the PDE6C gene, already related wit...

journal_title：Stem cell research

authors： Domingo-Prim J,Abad-Morales V,Riera M,Navarro R,Corcostegui B,Pomares E

更新日期：2019-10-01 00:00:00

abstract：:The KCL037 human embryonic stem cell line was derived from a normal healthy blastocyst donated for research. The ICM was isolated using laser microsurgery and plated on γ-irradiated human foreskin fibroblasts. Both the derivation and cell line propagation were performed in an animal product-free environment and under ...

journal_title：Stem cell research

authors： Miere C,Wood V,Kadeva N,Cornwell G,Codognotto S,Stephenson E,Ilic D

更新日期：2016-01-01 00:00:00

abstract：:Both BMP and Wnt signaling control stem cells in bulge/dermal papilla, intestinal crypt, and bone marrow. To explore their roles in the limbal niche, which govern corneal epithelial homeostasis, we established an in vitro model of sphere growth by reunion between single limbal epithelial progenitor cells (LEPCs) and a...

journal_title：Stem cell research

authors： Han B,Chen SY,Zhu YT,Tseng SC

更新日期：2014-03-01 00:00:00

abstract：:SOX4 has been shown to promote neuronal differentiation both in the adult and embryonic neural progenitors. Ectopic SOX4 expression has also been shown to inhibit oligodendrocyte differentiation in mice, however the underlying molecular mechanisms remain poorly understood. Here we demonstrate that SOX4 regulates trans...

journal_title：Stem cell research

authors： Braccioli L,Vervoort SJ,Puma G,Nijboer CH,Coffer PJ

更新日期：2018-12-01 00:00:00

abstract：:To develop a disease model for the human 'brittle bone' disease, osteogenesis imperfecta, we have used gene editing to produce a facsimile of the patient heterozygous COL1A1 mutation in an established control iPSC line. The gene-edited line had a normal karyotype, expressed pluripotency markers and differentiated into...

journal_title：Stem cell research

authors： Hosseini Far H,Patria YN,Motazedian A,Elefanty AG,Stanley EG,Lamandé SR,Bateman JF

更新日期：2019-05-01 00:00:00

abstract：:Two iPSC clones, NCCSi008-A and NCCSi008-B, were generated from a healthy male individual of Indian origin by reprogramming his CD4+ T cells with an integration free Sendai viral vector. The established iPSC clones showed high alkaline phosphatase (ALP) activity, expression of pluripotency markers, a normal male karyo...

journal_title：Stem cell research

authors： Vaidyanath A,Khan M,Shiras A

更新日期：2020-05-01 00:00:00

abstract：:Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs). However, the differentiation from OPCs to oligodendrocytes is disturbed under stressed conditions. Therefore, drugs that can improve oligodendrocyte regeneration ma...

journal_title：Stem cell research

authors： Maki T,Takahashi Y,Miyamoto N,Liang AC,Ihara M,Lo EH,Arai K

更新日期：2015-07-01 00:00:00

abstract：:Rabbit induced pluripotent stem cells (rbiPSCs) possess the characteristic features of primed pluripotency as defined in rodents and primates. In the present study, we reprogrammed rbiPSCs using human Krüppel-like factors (KLFs) 2 and 4 and cultured them in a medium supplemented with fetal calf serum and leukemia inhi...

journal_title：Stem cell research

authors： Tapponnier Y,Afanassieff M,Aksoy I,Aubry M,Moulin A,Medjani L,Bouchereau W,Mayère C,Osteil P,Nurse-Francis J,Oikonomakos I,Joly T,Jouneau L,Archilla C,Schmaltz-Panneau B,Peynot N,Barasc H,Pinton A,Lecardonnel J,Gocz

更新日期：2017-10-01 00:00:00

abstract：:Mouse embryonic stem cell (mESC) lines were derived by crossing heterozygous transgenic (tg) mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase (TH) promoter, with homozygous alpha-synuclein (aSYN) mice expressing human mutant SNCAA53T under the control of the mouse Prion...

journal_title：Stem cell research

authors： Chumarina M,Azevedo C,Bigarreau J,Vignon C,Kim KS,Li JY,Roybon L

更新日期：2017-03-01 00:00:00

abstract：:The peptide hormone insulin produced by pancreatic β-cells undergoes post-transcriptional processing before secretion. In particular, C-peptide is cleaved from pro-insulin to generate mature insulin. Here, we introduce a C-peptide-mCherry human iPSC line (HMGUi001-A-8). The line was generated by CRISPR/Cas9 mediated h...

journal_title：Stem cell research

authors： Siehler J,Blöchinger AK,Akgün M,Wang X,Shahryari A,Geerlof A,Lickert H,Burtscher I

更新日期：2020-12-16 00:00:00

abstract：:We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a 51years old female patient homozygous for the mutation c.535 G>A p.G179S on the KCNQ1 gene, causing a severe form of autosomal recessive Long QT Syndrome type 1 (AR-LQT1), not associated with deafness. The hiPSCs, generated using f...

journal_title：Stem cell research

authors： Mura M,Ginevrino M,Zappatore R,Pisano F,Boni M,Castelletti S,Crotti L,Valente EM,Schwartz PJ,Gnecchi M

更新日期：2018-05-01 00:00:00

abstract：:Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disordersmay yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a ne...

journal_title：Stem cell research

authors： Kamand M,Ilieva M,Forsberg SL,Thomassen M,Svenningsen ÅF,Meyer M,Michel TM

更新日期：2020-12-01 00:00:00

abstract：:TET proteins have been found to play an important role in active demethylation at CpG sites in mammals. There are some reports implicating their functions in removal of DNA methylation imprint at the imprinted regions in the germline. However, it is not well established whether TET proteins can also be involved in dem...

journal_title：Stem cell research

authors： Liu L,Mao SQ,Ray C,Zhang Y,Bell FT,Ng SF,Xu GL,Li X

更新日期：2015-09-01 00:00:00

abstract：:Autosomal recessive Stargardt disease is the most common cause of inherited retinal disease. In this report, we describe the generation and characterization of two human induced pluripotent stem cell (iPSC) lines from a patient with compound heterozygous mutations in the ABCA4 gene (c.[768G>T];[6079C>T]). Patient derm...

journal_title：Stem cell research

authors： Jennings L,Zhang D,Chen SC,Moon SY,Lamey T,Thompson JA,McLaren T,De Roach JN,Chen FK,McLenachan S

更新日期：2020-10-01 00:00:00

abstract：:Recent clinical trials show the efficacy of Adipose-derived Stromal Cells (ASCs) in contrasting the osteoarthritis scenario. Since it is quite accepted that ASCs act predominantly through a paracrine mechanism, their secretome may represent a valid therapeutic substitute. The aim of this study was to investigate the e...

journal_title：Stem cell research

authors： Niada S,Giannasi C,Gomarasca M,Stanco D,Casati S,Brini AT

更新日期：2019-07-01 00:00:00

abstract：:In the present study, we investigated the effect of simultaneous downregulation of uPAR and cathepsin B (pUC), alone or in combination with radiation, on JNK-MAPK signaling pathway in regulating the migration of non-GICs (glioma-initiating cells) and GICs. The increase in the expression of p-JNK with pUC treatment was...

journal_title：Stem cell research

authors： Alapati K,Kesanakurti D,Rao JS,Dasari VR

更新日期：2014-05-01 00:00:00

abstract：:Liver progenitor (oval) cells have enormous potential in the treatment of patients with liver disease using a cell therapy approach, but their use is limited by their scarcity and the number of donor livers from which they can be derived. Bone marrow may be a suitable source. Previously the derivation of oval cells fr...

journal_title：Stem cell research

authors： Tonkin JN,Knight B,Curtis D,Abraham LJ,Yeoh GC

更新日期：2008-09-01 00:00:00

abstract：:The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal. LQT3 is caused by mutation in gene SCN5A, which codes for the Nav1.5 Na+ channel. Herein, we have generated a human emb...

journal_title：Stem cell research

authors： Yang X,Wu F,Zhong J,Li F

更新日期：2021-01-25 00:00:00

abstract：:The KCL017 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting splicing site of the VHL gene encoding von Hippel-Lindau tumor suppressor E3 ubiquitin protein ligase (676+3A>T). The ICM was isolated using laser microsurgery and plated on γ...

journal_title：Stem cell research

authors： Hewitson H,Wood V,Kadeva N,Cornwell G,Codognotto S,Stephenson E,Ilic D

更新日期：2016-03-01 00:00:00

abstract：:The Global Alliance for iPSC Therapies (GAiT) is a new initiative to support the implementation and clinical application of therapies derived from pluripotent stem cells to the benefit of patients globally. GAiT's mission is to serve as a central, international resource for those organisations developing therapies fro...

journal_title：Stem cell research

authors： Sullivan S,Ginty P,McMahon S,May M,Solomon SL,Kurtz A,Stacey GN,Bennaceur Griscelli A,Li RA,Barry J,Song J,Turner ML

更新日期：2020-12-01 00:00:00

abstract：:Gene therapy mediated by bone marrow-derived hematopoietic stem cells (BM-HSC) has been widely used in treating genetic deficiencies in both pre-clinical and clinical settings. Using mitotically inactive cell-targeting lentivirus with separate promoters for our gene of interest (the murine MHC class II (MHCII) chapero...

journal_title：Stem cell research

authors： Wang N,Rajasekaran N,Hou T,Mellins ED

更新日期：2014-01-01 00:00:00

abstract：:Novel and complementary experimental models are required for investigating the molecular mechanisms underlying the resistance to the available therapies of patients with major depression (Treatment-Resistant Depression, TRD) that occurs in at least one third of patients and need to be deeply investigated. Here, we hav...

journal_title：Stem cell research

authors： Bono F,Mutti V,Piovani G,Minelli A,Mingardi J,Guglielmi A,Fiorentini C,Barbon A,Missale C,Gennarelli M

更新日期：2020-12-01 00:00:00

abstract：:Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. As a part of this network, the heteromeric transcription factor GA-binding protein (GABP) plays a crucial role in self-renewal of m...

journal_title：Stem cell research

authors： Manukjan G,Ripperger T,Venturini L,Stadler M,Göhring G,Schambach A,Schlegelberger B,Steinemann D

更新日期：2016-05-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) suppress T cell responses through mechanisms not completely understood. Adenosine is a strong immunosuppressant that acts mainly through its receptor A(2a) (ADORA2A). Extracellular adenosine levels are a net result of its production (mediated by CD39 and CD73), and of its conversion in...

journal_title：Stem cell research

authors： Saldanha-Araujo F,Ferreira FI,Palma PV,Araujo AG,Queiroz RH,Covas DT,Zago MA,Panepucci RA

更新日期：2011-07-01 00:00:00

abstract：:The aim of this study was to determine whether the growth and differentiation of limbal epithelial stem cell cultures could be controlled through manipulation of the oxygen tension. Limbal epithelial cells were isolated from corneoscleral disks, and cultured using either feeder cells in a growth medium supplemented wi...

journal_title：Stem cell research

authors： Bath C,Yang S,Muttuvelu D,Fink T,Emmersen J,Vorum H,Hjortdal J,Zachar V

更新日期：2013-05-01 00:00:00

abstract：:The KCL018 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting one allele of the DMPK gene encoding the dystrophia myotonica protein kinase (2200 trinucleotide repeats; 14 for the normal allele). The ICM was isolated using laser microsurg...

journal_title：Stem cell research

authors： Miere C,Hewitson H,Devito L,Wood V,Kadeva N,Cornwell G,Codognotto S,Stephenson E,Ilic D

更新日期：2016-03-01 00:00:00

abstract：:OCT4 and NANOG are core transcription factor genes in self-renewal, differentiation, and reprogramming. Here, we generated an OCT4-EGFP, NANOG-tdTomato dual reporter hiPSC line, KKUi001-A, on the basis of human induced pluripotent stem cells using CRISPR/Cas9 technology. EGFP and tdTomato reporter were inserted into b...

journal_title：Stem cell research

authors： Lee M,Choi NY,Park S,Bang JS,Lee Y,Jeong D,Ham S,Lim S,Kim KH,Ko K

更新日期：2020-10-01 00:00:00

abstract：:Transgene free UNIPDi002-A-human induced pluripotent stem cell (hiPSC) line was generated by Sendai Virus Vectors reprogramming from human oral mucosal epithelial stem cells (hOMESCs) of a patient affected by ectrodactyly-ectodermal dysplasia-clefting (EEC)-syndrome, carrying a mutation in exon 8 of the TP63 gene (R30...

journal_title：Stem cell research

authors： Trevisan M,Barbaro V,Riccetti S,Masi G,Barzon L,Nespeca P,Alvisi G,Di Iorio E,Palù G

更新日期：2018-04-01 00:00:00

abstract：:Tumor protein p63 (p63) encodes for a transcription factor of the p53 family and is a marker for respiratory basal cells. Based on a NKX2.1 knock-in reporter cell line from human induced pluripotent stem cells (hiPSCs) (MHHi06-A-2) we established a NKX2.1/p63 double transgenic knock-in reporter cell line using TALEN t...

journal_title：Stem cell research

authors： Drick N,Sahabian A,Pongpamorn P,Merkert S,Göhring G,Welte T,Martin U,Olmer R

更新日期：2020-01-01 00:00:00

abstract：:Human induced pluripotent stem cell-lines (iPSCs) of Indian origin NCCSi005A and NCCSi006A were established by reprogramming of CD4+T cells, isolated from the peripheral blood mononuclear cells (PBMCs) of two healthy female donors. Reprogramming was achieved using integration free, Sendai viral vector system expressin...

journal_title：Stem cell research

authors： Khan M,Zende S,Vaidyanath A,Avatade R,Shiras A

更新日期：2019-08-01 00:00:00