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Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A.

Abstract：

:The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal. LQT3 is caused by mutation in gene SCN5A, which codes for the Nav1.5 Na+ channel. Herein, we have generated a human embryonic stem cell line (WAe009-A-48) carrying a LQTS related mutation in SCN5A (WAe009-A-48). The WAe009-A-48 line maintained stem cell like morphology, pluripotency, normal karyotype and could differentiate into all three germ layers in vivo.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Yang X,Wu F,Zhong J,Li F

doi

10.1016/j.scr.2021.102194

subject

Has Abstract

pub_date

2021-01-25 00:00:00

pages

102194

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(21)00040-4

journal_volume

51

pub_type

杂志文章

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