Generation of induced pluripotent stem cell (iPSC) line from a patient with triple negative breast cancer with hereditary exon 17 deletion of BRCA1 gene.

Abstract:

:BRCA1 germline mutation confers hereditary predisposition for breast and ovarian cancer. To understand the physiopathology of mammary and ovarian epithelial cancer transformation, and to identify early driver molecular events, we have generated an iPSC line from a patient carrying a germline exon 17 deletion in BRCA1 gene (BRAC1Ex17 iPSC) in a high-risk family context. Blood cells were reprogrammed used non-integrative virus of Sendaï. The BRCA1-deleted iPSC had normal karyotype, harboured a deletion in the exon 17 of the BRCA1 gene, expressed pluripotent hallmarks and had the differentiation capacity into the three germ layers.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Griscelli F,Oudrhiri N,Feraud O,Divers D,Portier L,Turhan AG,Bennaceur Griscelli A

doi

10.1016/j.scr.2017.09.003

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

135-138

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(17)30188-5

journal_volume

24

pub_type

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