Abstract:
:Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disordersmay yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a newhuman inducedpluripotentstem cell (iPSC) line (SDUKIi004-A) generated from skin fibroblasts derived from a 21-year old male patient diagnosed with Pervasive DevelopmentalDisorder-Not Otherwise Specified (PDD-NOS)("FYNEN-cohort"). Reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Kamand M,Ilieva M,Forsberg SL,Thomassen M,Svenningsen ÅF,Meyer M,Michel TMdoi
10.1016/j.scr.2020.102038subject
Has Abstractpub_date
2020-12-01 00:00:00pages
102038eissn
1873-5061issn
1876-7753pii
S1873-5061(20)30339-1journal_volume
49pub_type
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journal_title:Stem cell research
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journal_title:Stem cell research
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journal_title:Stem cell research
pub_type: 杂志文章
doi:10.1016/j.scr.2018.10.005
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