Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration.

Abstract:

:A DAND5-control human iPSC line was generated from the urinary cells of a phenotypically normal donor. Exfoliated renal epithelial (RE) cells were collected and reprogrammed into iPSCs using Sendai virus reprogramming system. The pluripotency, in vitro differentiation potential, karyotype stability, and the transgene-free status of generated iPSC line were analyzed and confirmed. This cell line can be exploited as a control iPSC line to better understand the mechanisms involved in DAND5-associated cardiac disease.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Pars S,Cristo F,Inácio JM,Rosas G,Carreira IM,Melo JB,Mendes P,Martins DS,de Almeida LP,Maio J,Anjos R,Belo JA

doi

10.1016/j.scr.2018.04.015

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

202-206

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(18)30116-8

journal_volume

29

pub_type

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