Abstract:
:Human embryonic stem cell (hESC) line chHES-478 was derived from abnormal blastocyst diagnosed with albinism after preimplantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that chHES-478 cell line carried a compound heterozygous mutation, c.896G>A(p.Arg299His) and c.929_930insC(p.Pro310Glnfs*9), of TYR gene. Characteristic tests proved that the chHES-478 cell line presented typical markers of pluripotency and had the capability to form the three germ layers both in vitro and in vivo.
journal_name
Stem Cell Resjournal_title
Stem cell researchauthors
Sun Y,Zhou X,Chen J,Du J,Lu G,Lin G,Ouyang Qdoi
10.1016/j.scr.2016.11.004subject
Has Abstractpub_date
2016-11-01 00:00:00pages
643-645issue
3eissn
1873-5061issn
1876-7753pii
S1873-5061(16)30174-Xjournal_volume
17pub_type
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