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Derivation of LIF-independent mouse iPS cells with modified Oct4.

Abstract：

:It has been very difficult, if not impossible, to establish mouse induced pluripotent stem cells (iPSCs) from differentiated cells, such as fibroblasts, without leukemia inhibitory factor (LIF). We have established and maintained LIF-independent iPSCs for longer than 120 days with modified Oct4 along with Sox2, Klf4, and c-Myc. The iPSCs will provide a novel tool to investigate the roles of the LIF-Stat3 signaling pathway in mouse pluripotent stem cells.

journal_name

Stem Cell Res

journal_title

Stem cell research

authors

Hirai H,Firpo M,Kikyo N

doi

10.1016/j.scr.2015.08.005

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

384-6

issue

2

eissn

1873-5061

issn

1876-7753

pii

S1873-5061(15)00108-7

journal_volume

15

pub_type

杂志文章

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