Abstract：
:The first of its kind, this study determined whether blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress (PTS) symptoms in 78 military explosives operators. In all models, blast-exposed 5HTTLPR S carriers registered definitively higher PTS symptoms in comparison to non-exposed S carriers, as well as exposed and non-exposed LL carriers (all p < 0.01). All findings were robust to confounding influences of age and traumatic brain injury diagnosis. Not only is blast exposure prevalent in EOD personnel, but it also interacts with genetic predisposition to predict trauma symptoms in this unique, at-risk military population.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Taylor MK,Hernández LM,Stump J,Tschiffely AE,Goforth CW,Laver DC,Ahlers STdoi
10.1016/j.psychres.2019.112519subject
Has Abstractpub_date
2019-10-01 00:00:00pages
112519eissn
0165-1781issn
1872-7123pii
S0165-1781(19)31336-8journal_volume
280pub_type
杂志文章abstract：:Previous functional neuroimaging studies of posttraumatic stress disorder (PTSD) have mainly focused on symptom-provocation paradigms in combat-related PTSD. We sought to elucidate the effect of non-combat-related PTSD on the physiology of social cognition. Thirteen patients with PTSD underwent functional magnetic res...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.05.012
更新日期：2005-10-30 00:00:00
abstract：:In a previous study, we reported a nonrandom segregation between schizophrenia and the pseudoautosomal locus DXYS14 in a sample of 33 sibships. That study has been extended by the addition of 16 new sibships from 16 different families. Data from six other loci of the pseudoautosomal region and of the immediately adjac...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90083-3
更新日期：1994-05-01 00:00:00
abstract：:The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment-resistant gro...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.037
更新日期：2016-11-30 00:00:00
abstract：:The objective of this paper was to examine the efficacy of mindfulness-based cognitive therapy (MBCT) in decreasing depressive symptoms and intellectual disabilities (ID) among individuals with depression in Nigeria. In this randomized controlled trial, 101 participants with depression and ID, aged 18-60 years, who ob...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113680
更新日期：2020-12-24 00:00:00
abstract：:Haloperidol and reduced haloperidol plasma concentrations were measured in age-matched Chinese and non-Chinese patients (n = 32). Steady-state plasma concentrations were obtained 10-12 hours after the bedtime dose. Haloperidol and reduced haloperidol concentrations were measured by liquid chromatography and radioimmun...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90170-4
更新日期：1989-10-01 00:00:00
abstract：:Structural cerebral abnormalities are frequently observed in schizophrenia. These abnormalities may indicate vulnerability for the disorder, as evidenced by reports of familial clustering of measures identified through region-of-interest analyses using manual outlining procedures. We used computational morphometry to ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(02)00125-7
更新日期：2003-04-01 00:00:00
abstract：:This study was designed to determine the effects of aging on the volume of the basal ganglia in individuals with Down syndrome (DS) and to examine the relationship between basal ganglia volumes, neuropsychological test performance, and dementia status in this population. Subjects were 32 adults with DS. Basal ganglia ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(97)00011-5
更新日期：1997-05-16 00:00:00
abstract：:Neuropsychological performance was examined in a sample of 100 children between the ages of 6 and 18 years who met DSM-III-R criteria for Tourette's syndrome. Neuropsychological test scores were converted to age-corrected t scores based on published normative data. Ratings of Tourette's symptoms were also obtained. Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90150-4
更新日期：1990-07-01 00:00:00
abstract：:Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristic...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.10.001
更新日期：2008-02-28 00:00:00
abstract：:Psychotic-like experiences (PLEs) are sub-psychotic expressions of the psychosis continuum. Several studies have suggested multifactorial models, including a bifactor model, of the putative PLEs assessed with the popular Community Assessment of Psychic Experiences (CAPE) questionnaire. Our confirmatory results in a ge...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.12.023
更新日期：2016-01-30 00:00:00
abstract：:Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.029
更新日期：2011-03-30 00:00:00
abstract：:Traditional analyses and interpretation of controlled trials rely on measures of central tendency (e.g., mean findings for treatment versus control) to detect treatment effects. These trial designs therefore emphasize homogeneity of results, with variations within the experimental or control groups treated as error to...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.112520
更新日期：2020-01-01 00:00:00
abstract：:We investigated the serotonin transporter gene (5-HTTLPR) in the functioning of euthymic patients with mood disorders (n=285) and healthy controls (n=94). The 5-HTTLPR genotype showed marginal associations with working, familial and social adjustment, with marked differences between controls and patients. Because of t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.01.006
更新日期：2005-04-15 00:00:00
abstract：:Many soldiers with mental illness (SWMIs) struggle with the decision whether to disclose their condition in or outside the military. This study therefore explored views on (self-)labeling as 'mentally ill', experiences of discrimination and coping, risks and benefits of (non-)disclosure, service use, disclosure decisi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.028
更新日期：2017-12-01 00:00:00
abstract：:High affinity 3H-paroxetine binding was studied in human frontal cortex and hippocampus obtained from normal controls and alcoholics. On the basis of Scatchard analyses, a significant decrease in the maximal number of binding sites (Bmax) was found in the hippocampus of alcoholics (n = 8) as compared with that of cont...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90019-l
更新日期：1991-09-01 00:00:00
abstract：:The study reported herein explored the comprehension of metaphor and irony in schizophrenia during remission, and examined the role of IQ and a theory of mind. Performance of 29 Schizophrenic patients in remission and 22 healthy controls was compared on metaphor and irony comprehension tasks and first- and second-orde...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.002
更新日期：2008-01-15 00:00:00
abstract：:This study was aimed to explore clinical differences between women and men with schizophrenia (SZ) in Latin-America. It was conducted in public mental health centers in Bolivia, Peru and Chile. Two hundred forty-seven SZ patients participated in the study, 83 (33.6%) were women and 115 (46.6%) were Aymara. Compared to...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.05.032
更新日期：2018-08-01 00:00:00
abstract：:While social anhedonia is a promising indicator of vulnerability to schizophrenia, it remains uncertain whether anhedonia is a core feature of schizotypy or merely a secondary associated characteristic. This issue was examined by comparing dimensional scores on schizophrenia spectrum personality disorder symptoms deri...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.06.002
更新日期：2007-01-15 00:00:00
abstract：:Tobacco smoking is highly prevalent in patients with schizophrenia and alcohol dependence. The underlying neurobiology of nicotine addiction is complex. Rewarding effects of nicotine from cigarettes are associated, among others, with mu-opioid receptors encoded by the OPRM1 gene. The aim of the study was to evaluate t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113278
更新日期：2020-09-01 00:00:00
abstract：:Seventeen obsessive-compulsive disorder (OCD) patients and 25 normal control subjects submitted 24-hour urine samples for measurement of urinary free cortisol (UFC). Thirteen of the 17 OCD patients submitted a second 24-hour urine collection after a 10-week trial of either clomipramine (n = 6) or placebo (n = 7). At b...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90081-f
更新日期：1990-05-01 00:00:00
abstract：:Stressful life events (SLEs) are associated with increased risk for suicidal behavior. Less is known regarding the intensity of SLEs and how this may vary as a function of suicide attempt history. As a large percentage of suicide decedents do not have a history of suicidal behavior, SLEs precipitating suicide may help...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.06.078
更新日期：2017-10-01 00:00:00
abstract：:Male research subjects were administered placebo and three doses of d-amphetamine (5, 10, and 20 mg/70 kg of body weight) under double-blind conditions in a laboratory situation that provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentati...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(87)90030-8
更新日期：1987-07-01 00:00:00
abstract：:Diminished facial expressivity is a common feature of schizophrenia that interferes with effective interpersonal communication. This study was designed to determine if real-time visual feedback improved the ability of patients with schizophrenia to imitate and produce modeled facial expressions. Twenty patients with s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.12.007
更新日期：2006-12-07 00:00:00
abstract：:This article illustrates how Exploratory Data Analysis (EDA) can complement conventional statistical methods in evaluating psychiatric tests. Using one recent EDA computer program, we evaluated the ability of repeated psychiatric screening tests (the General Health Questionnaire [GHQ]) to predict medical and psychiatr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90009-e
更新日期：1991-10-01 00:00:00
abstract：:The aim of this study was to examine associations of major depressive disorder (MDD), its distinct subtypes, and symptom severity with the individual lifestyle factors smoking, diet quality, physical activity, and body mass index as well as with a combined lifestyle index measuring the co-occurrence of these lifestyle...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.035
更新日期：2016-11-30 00:00:00
abstract：:Vascular dementia (VaD) is characteristic of chronic brain ischemia and progressive memory decline, which has a high incidence in the elderly. However, there are no effective treatments for VaD, and the underlying mechanism of its pathogenesis remains unclear. This study investigated the effects of a synthetic cannabi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.012
更新日期：2018-09-01 00:00:00
abstract：:Major depressive disorder (MDD) had been associated with brain-derived neurotrophic factor (BDNF). Studies had shown that patients with MDD were associated with lower BDNF protein levels, which could be reversed by antidepressant treatment. BDNF expression had also been affected by a number of microRNAs (miRNA). BDNF ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.09.025
更新日期：2018-12-01 00:00:00
abstract：:This study aimed to investigate whether cognitive impairment is more pronounced in people with treatment-resistant schizophrenia compared with those who respond well to first-line antipsychotic medication. Fifty-one patients with schizophrenia were assigned to one of three groups dependent on their clinical history: (...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.10.036
更新日期：2015-12-30 00:00:00
abstract：:Dopaminergic abnormalities in bulimia nervosa have been reported in some studies, but results are not consistent across studies. In the present study, clinical characteristics, plasma level of homovanillic acid (pHVA) and two scales - the Eating Attitudes Test (EAT) and the Beck Depression Inventory (BDI) - were asses...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.06.046
更新日期：2009-12-30 00:00:00
abstract：:Patients with psychosis have been found to suffer from physical illnesses more commonly than the general population. In this report, self-reported physical ill health and its correlates among subjects with and without vulnerability to psychosis in a sample of first-degree relatives, help-seekers and controls were inve...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.03.016
更新日期：2007-04-15 00:00:00
