Immunization strategies against henipaviruses.

abstract：:An evolution in modern malaria research occurred with the completion of the Plasmodium falciparum genome project and the onset and application of novel post-genomic technologies. Corresponding with these technological achievements are improvements in accessing and purifying parasite material from 'hard-to-reach' stage...

journal_title：Current topics in microbiology and immunology

authors： Blair PL,Carucci DJ

更新日期：2005-01-01 00:00:00

abstract：:Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it ...

journal_title：Current topics in microbiology and immunology

authors： Blondel B,Colbère-Garapin F,Couderc T,Wirotius A,Guivel-Benhassine F

更新日期：2005-01-01 00:00:00

abstract：:Our knowledge of the organization and regulation of the murine hematopoietic stem cell hierarchy has, in large measure, been the result of the development of in vivo reconstitution assays for cells of various levels of differentiation. For example, many basic stem cell concepts were established using CFU-S as a paradi...

journal_title：Current topics in microbiology and immunology

authors： Dick JE

更新日期：1989-01-01 00:00:00

abstract：:Various gram-negative pathogens express type IV secretion systems (T4SSs) which translocate bacterial virulence factors into host target cells to hijack cellular processes for their own benefit and causing disease. The pathology of Helicobacter pylori, the causative agent of chronic gastritis, peptic ulcer disease, an...

journal_title：Current topics in microbiology and immunology

authors： Backert S,Haas R,Gerhard M,Naumann M

更新日期：2017-01-01 00:00:00

abstract：:There is currently a handful of genome sequences available for tailed bacteriophages with genomes of more than 200 kbp of DNA, designated here as giant or jumbo phages. The majority of the proteins predicted from the genome sequences of these phages have no matches in the current sequence databases, and the genomes th...

journal_title：Current topics in microbiology and immunology

authors： Hendrix RW

更新日期：2009-01-01 00:00:00

abstract：:HAM/TSP is a chronic inflammatory disease of the spinal cord. It is rather rare in HTLV-1-infected individuals. Immunogenetic factors of the HLA complex have been identified that support or prevent the development of the disease. In HAM/TSP patients a characteristic constellation of high proviral loads and increased c...

journal_title：Current topics in microbiology and immunology

authors： Kitze B,Usuku K

更新日期：2002-01-01 00:00:00

abstract：:Rabies, being a major zoonotic disease, significantly impacts global public health. It is invariably fatal once clinical signs are apparent. The majority of human rabies deaths occur in developing countries. India alone reports more than 50% of the global rabies deaths. Although it is a vaccine-preventable disease, ef...

journal_title：Current topics in microbiology and immunology

authors： Nagarajan T,Rupprecht CE,Dessain SK,Rangarajan PN,Thiagarajan D,Srinivasan VA

更新日期：2008-01-01 00:00:00

abstract：:Our incomplete understanding of the mechanisms that orchestrate human lymphocyte differentiation and condition human immune responses is in part due to the limited access to normal human tissue samples that can inform on these complex processes. In addition, in vitro culture conditions fail to recapitulate the three-d...

journal_title：Current topics in microbiology and immunology

authors： Li Y,Di Santo JP

更新日期：2016-01-01 00:00:00

abstract：:Despite the wealth of data describing the ecological factors that underpin viral emergence, little is known about the evolutionary processes that allow viruses to jump species barriers and establish productive infections in new hosts. Understanding the evolutionary basis to virus emergence is therefore a key research ...

journal_title：Current topics in microbiology and immunology

authors： Holmes EC,Drummond AJ

更新日期：2007-01-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets ( Paguma larvata), togethe...

journal_title：Current topics in microbiology and immunology

authors： Wang LF,Eaton BT

更新日期：2007-01-01 00:00:00

abstract：:CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...

journal_title：Current topics in microbiology and immunology

authors： Tanaka H,Taniuchi I

更新日期：2014-01-01 00:00:00

abstract：:Natural and intentional biological risks threaten human civilization, both through direct human fatality as well as follow-on effects from a collapse of the just-in-time delivery system that provides food, energy and critical supplies to communities globally. Human beings have multiple innate cognitive biases that sys...

journal_title：Current topics in microbiology and immunology

authors： Luby S,Arthur R

更新日期：2019-01-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) perform diverse regulatory functions in transcription, translation' chromatin modification, and cellular organization. Misregulation of lncRNAs is found linked to various human diseases. Compared to protein-coding RNAs' lncRNAs are more specific to organs, tissues, cell types, development...

journal_title：Current topics in microbiology and immunology

authors： Nguyen Q,Carninci P

更新日期：2016-01-01 00:00:00

abstract：:The collaboration between Alick Isaacs and myself started in the summer of 1956. Our initial project was to show, by electron microscopy, that interference between inactivated influenza virus and live virus involved the transfer of material from the interfering virus to the host cell. This approach failed for technica...

journal_title：Current topics in microbiology and immunology

authors： Lindenmann J

更新日期：2007-01-01 00:00:00

abstract：:Specific T cell responses to a variety of self and microbial lipids depend on proper assembly and intracellular trafficking of CD 1 molecules that intersect with and load processed lipid antigens. These pathways involve unique membrane trafficking and chaperones that are distinct from those utilized for major histocom...

journal_title：Current topics in microbiology and immunology

authors： Sugita M,Barral DC,Brenner MB

更新日期：2007-01-01 00:00:00

abstract：:Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...

journal_title：Current topics in microbiology and immunology

authors： Steinman L,Utz PJ,Robinson WH

更新日期：2005-01-01 00:00:00

abstract：:Glucans are characteristic and major constituents of fungal cell walls. Depending on the species, different glucan polysaccharides can be found. These differ in the linkage of the D-glucose monomers which can be either in α- or β-conformation and form 1,3, 1,4 or 1,6 O-glycosidic bonds. The linkages and polymer length...

journal_title：Current topics in microbiology and immunology

authors： Wagener J,Striegler K,Wagener N

更新日期：2020-01-01 00:00:00

abstract：:Translocations or amplifications which activate members of the myc gene family are common in human cancer. c-Myc is a central regulator of normal cell proliferation and differentiation (Luscher and Eisenman, 1991; Marcu et al. 1992) and can induce apoptosis (Askew et al. 1991, 1993; Evan et al. 1992; Bissonette et al....

journal_title：Current topics in microbiology and immunology

authors： Packham G,Cleveland JL

更新日期：1995-01-01 00:00:00

abstract：:The ubiquitous, opportunistic pathogen human cytomegalovirus (CMV) encodes several proteins homologous to those of the host organism. Four different CMV genes encode chemokine receptor-like peptides. These genes, UL33, UL78, US27, and US28, are expressed at various stages of infection in vitro. Their functions remain ...

journal_title：Current topics in microbiology and immunology

authors： Beisser PS,Goh CS,Cohen FE,Michelson S

更新日期：2002-01-01 00:00:00

abstract：:Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T cell activation by APCs and immunological synapse formation. This review summarizes recent advances in our und...

journal_title：Current topics in microbiology and immunology

authors： Deckert M,Moon C,Le Bras S

更新日期：2005-01-01 00:00:00

abstract：:Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively...

journal_title：Current topics in microbiology and immunology

authors： Hayes JM,Cosgrave EF,Struwe WB,Wormald M,Davey GP,Jefferis R,Rudd PM

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis (Mtb) and represents one of the most relevant bacterial diseases worldwide. Recent advances have yielded new insights into the molecular basis of the immune response required for restriction of the pathogen and also highlighted determinants of im...

journal_title：Current topics in microbiology and immunology

authors： Ablasser A,Dorhoi A

更新日期：2016-01-01 00:00:00

abstract：:Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its targe...

journal_title：Current topics in microbiology and immunology

authors： Hagman J,Ramírez J,Lukin K

更新日期：2012-01-01 00:00:00

abstract：:Clostridium difficile causes infectious diarrhoea in humans and animals. It has been found in both diarrhoeal and non-diarrhoeal pigs, horses and cattle, suggesting a potential reservoir for human insection, and in 20-40 % of meat products in Canada and the USA, suggesting the possibility, albeit not proven, of food-b...

journal_title：Current topics in microbiology and immunology

authors： Squire MM,Riley TV

更新日期：2013-01-01 00:00:00

abstract：:The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. The Lyme disease spirochete has evolved mechanisms to sense its location in the infectious cycle, and use that information t...

journal_title：Current topics in microbiology and immunology

authors： Stevenson B,Seshu J

更新日期：2018-01-01 00:00:00

abstract：:Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermo...

journal_title：Current topics in microbiology and immunology

authors： Horiguchi Y

更新日期：2012-01-01 00:00:00

abstract：:Most eukaryotic messenger RNAs are transcribed as precursors that necessitate specific and exact processing of intron boundaries. Furthermore, the choice of these boundaries appears to be fluid and adaptive to the rate of transcription and the developmental and physiological state of the cell. A central regulator of s...

journal_title：Current topics in microbiology and immunology

authors： Fluhr R

更新日期：2008-01-01 00:00:00

abstract：:As the largest RNA virus, coronavirus replication employs complex mechanisms and involves various viral and cellular proteins. The first open reading frame of the coronavirus genome encodes a large polyprotein, which is processed into a number of viral proteins required for viral replication directly or indirectly. Th...

journal_title：Current topics in microbiology and immunology

authors： Shi ST,Lai MM

更新日期：2005-01-01 00:00:00

abstract：:Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...

journal_title：Current topics in microbiology and immunology

authors： Mori Y,Sadaoka T

更新日期：2010-01-01 00:00:00

abstract：:The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described ...

journal_title：Current topics in microbiology and immunology

authors： Refsland EW,Harris RS

更新日期：2013-01-01 00:00:00