B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.

abstract：:The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. The Lyme disease spirochete has evolved mechanisms to sense its location in the infectious cycle, and use that information t...

journal_title：Current topics in microbiology and immunology

authors： Stevenson B,Seshu J

更新日期：2018-01-01 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell,...

journal_title：Current topics in microbiology and immunology

authors： Skoberne M,Beignon AS,Larsson M,Bhardwaj N

更新日期：2005-01-01 00:00:00

abstract：:The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described ...

journal_title：Current topics in microbiology and immunology

authors： Refsland EW,Harris RS

更新日期：2013-01-01 00:00:00

abstract：:Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermo...

journal_title：Current topics in microbiology and immunology

authors： Horiguchi Y

更新日期：2012-01-01 00:00:00

abstract：:T cell activation begins with the interaction between an antigen-specific T cell and an antigen-presenting cell (APC). This interaction results in the formation of the immunological synapse, which had been considered to be responsible for antigen recognition and T cell activation. Recent advances in imaging analysis h...

journal_title：Current topics in microbiology and immunology

authors： Yokosuka T,Saito T

更新日期：2010-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world's population. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent grow...

journal_title：Current topics in microbiology and immunology

authors： Hislop AD,Taylor GS

更新日期：2015-01-01 00:00:00

abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...

journal_title：Current topics in microbiology and immunology

authors： Moss WJ

更新日期：2009-01-01 00:00:00

abstract：:Torque teno (TT) viruses have been more frequently reported in malignant biopsies when compared to normal control tissue. The possible contribution of TT virus infection to human carcinogenesis or the potential oncolytic functions of these virus infections are being discussed based on available experimental evidence. ...

journal_title：Current topics in microbiology and immunology

authors： zur Hausen H,de Villiers EM

更新日期：2009-01-01 00:00:00

abstract：:Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of th...

journal_title：Current topics in microbiology and immunology

authors： Roy CJ,Song K,Sivasubramani SK,Gardner DJ,Pincus SH

更新日期：2012-01-01 00:00:00

abstract：:In normal cells, the proto-oncogene c-myc is regulated by promoter-proximal pausing of RNA polymerase II (pol II). In Burkitt lymphoma cells, c-myc is chromosomally translocated to one of the three immunoglobulin (Ig) gene loci and its transcription is driven constitutively by Ig enhancers. Promoter-proximal pausing o...

journal_title：Current topics in microbiology and immunology

authors： Schneider EE,Albert T,Wolf DA,Eick D

更新日期：1999-01-01 00:00:00

abstract：:Japanese encephalitis (JE) is one of the most well studied arthropod zoonotic diseases with human and animal research and their integration spanning 6-7 decades. JE research and policy in some Asian countries has epitomized the 'One Health' strategy of attainment of optimal health for people, animals, and the environm...

journal_title：Current topics in microbiology and immunology

authors： Impoinvil DE,Baylis M,Solomon T

更新日期：2013-01-01 00:00:00

abstract：:During early stages of development, precursor B lymphocytes express a characteristic type of antigen receptor known as the pre-B-cell receptor (pre-BCR). This receptor differs from conventional BCRs in that it possesses a germ line-encoded surrogate light chain (SLC), which is associated with the signal transduction m...

journal_title：Current topics in microbiology and immunology

authors： Übelhart R,Werner M,Jumaa H

更新日期：2016-01-01 00:00:00

abstract：:We identified a population of IgM+IgD+ B-cells in the peripheral blood (PB) of humans that express somatically mutated V-region genes like classical class switched or IgM-only memory B-cells and comprise around 15% of PB B-cells in adults. Mutated IgM+IgD+ cells differ from unmutated naive IgM+IgD+ cells in that they ...

journal_title：Current topics in microbiology and immunology

authors： Klein U,Rajewsky K,Küppers R

更新日期：1999-01-01 00:00:00

abstract：:Epstein-Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with spec...

journal_title：Current topics in microbiology and immunology

authors： Frappier L

更新日期：2015-01-01 00:00:00

abstract：:While more and more attention has been paid to CpG-DNA with respect to its usefulness as an adjuvant, its molecular mechanism of action is less well defined. Over the last few years, at least two major signalling pathways have been shown to be utilized by CpG-DNA: the NF-kappa B activation pathway and the stress-kinas...

journal_title：Current topics in microbiology and immunology

authors： Häcker H

更新日期：2000-01-01 00:00:00

abstract：:The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that ...

journal_title：Current topics in microbiology and immunology

authors： Lindemann D,Goepfert PA

更新日期：2003-01-01 00:00:00

abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...

journal_title：Current topics in microbiology and immunology

authors： Gosztonyi G,Ludwig H

更新日期：1995-01-01 00:00:00

abstract：:The use of appropriate fluorescent proteins has allowed the use of FRET microscopy for investigation of intermolecular interactions in living cells. This method has the advantage of both being dynamic and of working at the subcellular level, so that the time and place where proteins interact can be visualized. We have...

journal_title：Current topics in microbiology and immunology

authors： Gascoigne NR,Ampudia J,Clamme JP,Fu G,Lotz C,Mallaun M,Niederberger N,Palmer E,Rybakin V,Yachi PP,Zal T

更新日期：2009-01-01 00:00:00

abstract：:The low-resource environment deprives healthcare providers caring for patients with Ebola virus disease (EVD) of many of the means employed for the critically ill that are available in better resourced settings, such as advanced therapeutic interventions and abundant staff. In addition to these limitations may be adde...

journal_title：Current topics in microbiology and immunology

authors： Sprecher A,Van Herp M,Rollin PE

更新日期：2017-01-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets ( Paguma larvata), togethe...

journal_title：Current topics in microbiology and immunology

authors： Wang LF,Eaton BT

更新日期：2007-01-01 00:00:00

abstract：:Picornavirus 5' NCRs contain IRES elements that have been divided into two groups, exemplified by PV (type 1) and EMCV (type 2). These elements are functionally related and have an intriguing level of structural and sequence similarity. Some conserved RNA sequences and/or structures may correspond to cis-acting elemen...

journal_title：Current topics in microbiology and immunology

authors： Hellen CU,Wimmer E

更新日期：1995-01-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiate...

journal_title：Current topics in microbiology and immunology

authors： Takeuchi O,Akira S

更新日期：2002-01-01 00:00:00

abstract：:Rhabdoviruses, mainly in rainbow trout, are among the most devastating viruses for worldwide aquaculture. To date no effective treatments to fight against these viruses are available. During the past years, several approaches to develop efficient vaccines have been undertaken such as the use of immunogenic recombinant...

journal_title：Current topics in microbiology and immunology

authors： Brémont M

更新日期：2005-01-01 00:00:00

abstract：:The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...

journal_title：Current topics in microbiology and immunology

authors： Offringa R,de Jong A,Toes RE,van der Burg SH,Melief CJ

更新日期：2003-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00

abstract：:Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in...

journal_title：Current topics in microbiology and immunology

authors： Corneth OBJ,Klein Wolterink RGJ,Hendriks RW

更新日期：2016-01-01 00:00:00

abstract：:In view of the recent studies on the CDCs, a reasonable schematic of the stages leading to membrane insertion of the CDCs can be assembled. As shown in Fig. 3, we propose that the CDC first binds to the membrane as a monomer. These monomers then diffuse laterally on the membrane surface to encounter other monomers or ...

journal_title：Current topics in microbiology and immunology

authors： Tweten RK,Parker MW,Johnson AE

更新日期：2001-01-01 00:00:00

abstract：:Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assemb...

journal_title：Current topics in microbiology and immunology

authors： Jaskiewicz L,Filipowicz W

更新日期：2008-01-01 00:00:00

abstract：:Our understanding of the mechanisms involved in the formation of the complex arrangement of neurons and their interconnections within the brain has made significant progress in recent years. Current research has uncovered a network of intracellular signaling events that provide precise coordination of a diverse array ...

journal_title：Current topics in microbiology and immunology

authors： Waite K,Eickholt BJ

更新日期：2010-01-01 00:00:00