Abstract:
:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of animals from birds to primates. The neuropathology after experimental infection is similar to that in natural disease but the inflammatory changes are more diffuse. In the rat and mouse, a persistent/tolerant infection can also be induced, in which inflammatory changes are conspicuously absent. In the course of persistent infection of the rat, an elective, focal degeneration ensues that involves the dentate gyrus, retina, and, less frequently, the magnocellular part of the hippocampus. The cytopathic destruction of the dentate gyrus is the likely anatomical substrate of learning deficiencies and behavioral changes, prominent features of chronic infection. Later in infection, more diffuse and random degeneration of neurons can be found. In all species infected, viral antigens are produced in excess and fill all neuronal processes. Beside neurons, glial cells are infected as well. The agent spreads in the nervous system axonally and transsynaptically (transneuronally). The type of neurotransmitter receptors in the synapse and their interaction with viral proteins may modulate the spread of infection (Gosztonyi et al. 1994). Virus particles have not been visualized in the brain in any phase of the disease. During persistent infection of the rat, production of viral proteins has a phasic character. Some rats survive acute infection and develop an obesity syndrome. The anatomical basis of this syndrome is not fully clarified; inflammatory destruction of the infundibular region, vacuolar degeneration of the paraventricular nucleus of the hypothalamus and severe, progressive involution of the hippocampal formation most probably play an important role in the production of this neuroendocrine syndrome. In the acute disease, inflammatory reaction can severely aggravate virus-induced cytopathology, but cannot be the sole cause of the neurological disease, since infection with high passage virus can lead to a similarly severe disease in the absence of inflammatory changes.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Gosztonyi G,Ludwig Hsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
39-73eissn
0070-217Xissn
2196-9965journal_volume
190pub_type
杂志文章,评审abstract::The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2016_501
更新日期:2016-01-01 00:00:00
abstract::Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that mol...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/82_2018_146
更新日期:2019-01-01 00:00:00
abstract::Inflammatory responses to microbial and non-microbial stimuli involve coordinate changes in the expression of hundreds of genes. The inflammatory gene expression programs display two important features: first, alternative stimuli affect both a large set of common genes and a variable number of stimulus-specific genes....
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2010_106
更新日期:2011-01-01 00:00:00
abstract::It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-29714-6_13
更新日期:2006-01-01 00:00:00
abstract::The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-37765-5_1
更新日期:2013-01-01 00:00:00
abstract::Leptospires are spirochetes that may be free-living saprophytes found in freshwater or may cause acute or chronic infection of animals. The family Leptospiraceae comprises three genera: Leptospira Leptospira Leptonema Leptonema, and Turneriella Turneriella. Within the genus Leptospira, three clades can be distinguishe...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-45059-8_2
更新日期:2015-01-01 00:00:00
abstract::The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-06508-2_10
更新日期:2003-01-01 00:00:00
abstract::The genetic differences that potentially account for the attenuation of the Oka vaccine VZV preparation are more clearly defined than for perhaps any other vaccine in current use. This is due in large part to the small number of differences between the vaccine and the parental strain from which it was derived, and to ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2010_14
更新日期:2010-01-01 00:00:00
abstract::Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusivelywith the un...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-55747-7_9
更新日期:2003-01-01 00:00:00
abstract::Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. I...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2017_23
更新日期:2017-01-01 00:00:00
abstract::The CBA/N strain carries xid, a murine btk missense mutation that reduces peripheral B cell numbers. Using in vivo BrdU labeling and cytofluorimetry, we have compared the magnitude, production rates, and turnover rates of each B lineage subset in the marrow and periphery of CBA/Ca and CBA/N mice. Our results show the ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/978-3-642-57284-5_4
更新日期:2000-01-01 00:00:00
abstract::Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-59674-2_10
更新日期:2000-01-01 00:00:00
abstract::The antiquated system used to manufacture the currently licensed inactivated influenza virus vaccines would not be adequate during an influenza virus pandemic. There is currently a search for vaccines that can be developed faster and provide superior, long-lasting immunity to influenza virus as well as other highly pa...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-92165-3_13
更新日期:2009-01-01 00:00:00
abstract::Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-30791-5_4
更新日期:2005-01-01 00:00:00
abstract::As the largest RNA virus, coronavirus replication employs complex mechanisms and involves various viral and cellular proteins. The first open reading frame of the coronavirus genome encodes a large polyprotein, which is processed into a number of viral proteins required for viral replication directly or indirectly. Th...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-26765-4_4
更新日期:2005-01-01 00:00:00
abstract::The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways u...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-07911-0_18
更新日期:2014-01-01 00:00:00
abstract::This chapter highlights the cholera situation in South Asia and the Bay of Bengal region, the original 'homeland' of cholera. A detailed discussion of cholera outbreaks in individual countries in South-East Asia follows. The countries of the World Health Organization (WHO) SEARO (South-East Asia Region) region are dis...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2014_362
更新日期:2014-01-01 00:00:00
abstract::Poxviruses have been long regarded as potent inhibitors of apoptotic cell death. More recently, they have been shown to inhibit necroptotic cell death through two distinct strategies. These strategies involve either blocking virus sensing by the host pattern recognition receptor, ZBP1 (also called DAI) or by influenci...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/82_2020_229
更新日期:2021-01-29 00:00:00
abstract::Climate change adds complexity and uncertainty to human health issues such as emerging infectious diseases, food security, and national sustainability planning that intensify the importance of interdisciplinary and collaborative research. Collaboration between veterinary, medical, and public health professionals to un...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_274
更新日期:2013-01-01 00:00:00
abstract::The prototypes of the human MYC and RAF gene families are orthologs of animal proto-oncogenes that were originally identified as transduced alleles in the genomes of highly oncogenic retroviruses. MYC and RAF genes are now established as key regulatory elements in normal cellular physiology, but also as major cancer d...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2017_4
更新日期:2017-01-01 00:00:00
abstract::Specific T cell responses to a variety of self and microbial lipids depend on proper assembly and intracellular trafficking of CD 1 molecules that intersect with and load processed lipid antigens. These pathways involve unique membrane trafficking and chaperones that are distinct from those utilized for major histocom...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-69511-0_6
更新日期:2007-01-01 00:00:00
abstract::CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2013_323
更新日期:2014-01-01 00:00:00
abstract::In most cases, the genetic engineering of plants uses Agrobacterium-mediated transformation to introduce novel genes. In nature, insertion of T-DNA into the plant genome and its subsequent transfer via sexual reproduction have been shown for several species in the genera Nicotiana, Ipomoea , and Linaria . A sequence h...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2018_80
更新日期:2018-01-01 00:00:00
abstract::Negative-strand RNA virus particles are formed by a process that includes the assembly of viral components at the plasma membranes of infected cells and the subsequent release of particles by budding. Here, we review recent progress that has been made in understanding the mechanisms of negative-strand RNA virus assemb...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-06099-5_5
更新日期:2004-01-01 00:00:00
abstract::Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-59672-8_15
更新日期:2000-01-01 00:00:00
abstract::Natural and intentional biological risks threaten human civilization, both through direct human fatality as well as follow-on effects from a collapse of the just-in-time delivery system that provides food, energy and critical supplies to communities globally. Human beings have multiple innate cognitive biases that sys...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2019_162
更新日期:2019-01-01 00:00:00
abstract::Epstein-Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with spec...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-22834-1_1
更新日期:2015-01-01 00:00:00
abstract::Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization. Several key fact...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-75418-3_12
更新日期:2008-01-01 00:00:00
abstract::Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of th...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/82_2011_173
更新日期:2012-01-01 00:00:00
abstract::The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mit...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_219
更新日期:2012-01-01 00:00:00