MyD88 as a bottle neck in Toll/IL-1 signaling.

abstract：:The field of autophagy research has advanced rapidly in recent years, with important discoveries made in relation to both molecular mechanisms and physiological functions. Initially, autophagy was thought to be primarily a response to starvation. Although this might be true in lower eukaryotes, this catabolic process ...

journal_title：Current topics in microbiology and immunology

authors： Mizushima N

更新日期：2009-01-01 00:00:00

abstract：:Commercial vaccines currently available against swine influenza virus (SIV) are inactivated, adjuvanted, whole virus vaccines, based on H1N1 and/or H3N2 and/or H1N2 SIVs. In keeping with the antigenic and genetic differences between SIVs circulating in Europe and the US, the vaccines for each region are produced local...

journal_title：Current topics in microbiology and immunology

authors： Van Reeth K,Ma W

更新日期：2013-01-01 00:00:00

abstract：:The bacterial type VI secretion system (T6SS) is a contractile nanomachine dedicated to delivering molecules out of bacterial cells. T6SS-encoding loci are in the genome sequences of many Gram-negative bacteria, and T6SS has been implicated in a plethora of roles. In the majority of cases, the T6SSs deliver effector p...

journal_title：Current topics in microbiology and immunology

authors： Wu CF,Smith DA,Lai EM,Chang JH

更新日期：2018-01-01 00:00:00

abstract：:Rabies, being a major zoonotic disease, significantly impacts global public health. It is invariably fatal once clinical signs are apparent. The majority of human rabies deaths occur in developing countries. India alone reports more than 50% of the global rabies deaths. Although it is a vaccine-preventable disease, ef...

journal_title：Current topics in microbiology and immunology

authors： Nagarajan T,Rupprecht CE,Dessain SK,Rangarajan PN,Thiagarajan D,Srinivasan VA

更新日期：2008-01-01 00:00:00

abstract：:The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments includ...

journal_title：Current topics in microbiology and immunology

authors： Hendriks A,Cruz AR,Soldaini E,Manetti AGO,Bagnoli F

更新日期：2018-09-20 00:00:00

abstract：:Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model. Multiple mechanisms of activation of c-myb by retroviral insertional mutagenesis implicate both transcriptional deregulation...

journal_title：Current topics in microbiology and immunology

authors： Wolff L,Koller R,Bies J,Nazarov V,Hoffman B,Amanullah A,Krall M,Mock B

更新日期：1996-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a member of the Paramyxoviridae family that consists of viruses with nonsegmented negative-strand RNA genome. Infection by these viruses triggers the innate antiviral response of the host, mainly type I interferon (IFN). Essentially all other viruses of this family produce IFN supp...

journal_title：Current topics in microbiology and immunology

authors： Barik S

更新日期：2013-01-01 00:00:00

abstract：:The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...

journal_title：Current topics in microbiology and immunology

authors： Offringa R,de Jong A,Toes RE,van der Burg SH,Melief CJ

更新日期：2003-01-01 00:00:00

abstract：:Single-cell technologies like mass cytometry enable researchers to comprehensively monitor signaling network responses in the context of heterogeneous cell populations. Cell-to-cell variability, the possibly nonlinear topology of signaling processes, and the destructive nature of mass cytometry necessitate nontrivial ...

journal_title：Current topics in microbiology and immunology

authors： Claassen M

更新日期：2014-01-01 00:00:00

abstract：:The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the ...

journal_title：Current topics in microbiology and immunology

authors： Dash P,Thomas PG

更新日期：2015-01-01 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:Most eukaryotic messenger RNAs are transcribed as precursors that necessitate specific and exact processing of intron boundaries. Furthermore, the choice of these boundaries appears to be fluid and adaptive to the rate of transcription and the developmental and physiological state of the cell. A central regulator of s...

journal_title：Current topics in microbiology and immunology

authors： Fluhr R

更新日期：2008-01-01 00:00:00

abstract：:This chapter highlights the cholera situation in South Asia and the Bay of Bengal region, the original 'homeland' of cholera. A detailed discussion of cholera outbreaks in individual countries in South-East Asia follows. The countries of the World Health Organization (WHO) SEARO (South-East Asia Region) region are dis...

journal_title：Current topics in microbiology and immunology

authors： Bharati K,Bhattacharya SK

更新日期：2014-01-01 00:00:00

abstract：:Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts in...

journal_title：Current topics in microbiology and immunology

authors： Broder CC,Geisbert TW,Xu K,Nikolov DB,Wang LF,Middleton D,Pallister J,Bossart KN

更新日期：2012-01-01 00:00:00

abstract：:Translocations or amplifications which activate members of the myc gene family are common in human cancer. c-Myc is a central regulator of normal cell proliferation and differentiation (Luscher and Eisenman, 1991; Marcu et al. 1992) and can induce apoptosis (Askew et al. 1991, 1993; Evan et al. 1992; Bissonette et al....

journal_title：Current topics in microbiology and immunology

authors： Packham G,Cleveland JL

更新日期：1995-01-01 00:00:00

abstract：:Genetic variation of the host significantly contributes to dramatic differences in the outcomes of natural infection with virulent Mycobacterium tuberculosis (MTB) in humans, as well as in experimental animal models. Host resistance to tuberculosis is a complex multifactorial genetic trait in which many genetic polymo...

journal_title：Current topics in microbiology and immunology

authors： Kramnik I

更新日期：2008-01-01 00:00:00

abstract：:The activation and expansion of T cells in an antimicrobial immune response is based on the ability of T cell receptors (TCR) to discriminate between MHC-bound peptides derived from different microbial agents as well as self-proteins. However, the specificity of T cells is constrained by the limited number of peptide ...

journal_title：Current topics in microbiology and immunology

authors： Wucherpfennig KW

更新日期：2005-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...

journal_title：Current topics in microbiology and immunology

authors： Chandrahas VK,Han J,Kaufman RJ

更新日期：2018-01-01 00:00:00

abstract：:The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma ...

journal_title：Current topics in microbiology and immunology

authors： Klahn P,Brönstrup M

更新日期：2016-01-01 00:00:00

abstract：:Cell-based therapies with various lymphocytes and antigen-presenting cells are promising approaches for cancer immunotherapy. The transfusion of T lymphocytes, also called adoptive cell therapy (ACT), is an effective treatment for viral infections, has induced regression of cancer in early stage clinical trials, and m...

journal_title：Current topics in microbiology and immunology

authors： Grupp SA,June CH

更新日期：2011-01-01 00:00:00

abstract：:Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is hig...

journal_title：Current topics in microbiology and immunology

authors： Habenstein B,El Mammeri N,Tolchard J,Lamon G,Tawani A,Berbon M,Loquet A

更新日期：2020-01-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth muscle cells are the predominant targets for virus ...

journal_title：Current topics in microbiology and immunology

authors： Sinzger C,Digel M,Jahn G

更新日期：2008-01-01 00:00:00

abstract：:There is currently a handful of genome sequences available for tailed bacteriophages with genomes of more than 200 kbp of DNA, designated here as giant or jumbo phages. The majority of the proteins predicted from the genome sequences of these phages have no matches in the current sequence databases, and the genomes th...

journal_title：Current topics in microbiology and immunology

authors： Hendrix RW

更新日期：2009-01-01 00:00:00

abstract：:Various gram-negative pathogens express type IV secretion systems (T4SSs) which translocate bacterial virulence factors into host target cells to hijack cellular processes for their own benefit and causing disease. The pathology of Helicobacter pylori, the causative agent of chronic gastritis, peptic ulcer disease, an...

journal_title：Current topics in microbiology and immunology

authors： Backert S,Haas R,Gerhard M,Naumann M

更新日期：2017-01-01 00:00:00

abstract：:The incidence of Kaposi sarcoma (KS) related to Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) after organ transplantation is 500-1000 times greater than in the general population, and its occurrence is associated with immunosuppressive therapy. The reported incidence of posttransplant KS ranges from 0.5% to 5%, d...

journal_title：Current topics in microbiology and immunology

authors： Marcelin AG,Calvez V,Dussaix E

更新日期：2007-01-01 00:00:00

abstract：:Hemopoietic cells express relatively high levels of the type I phosphoinositide (PI) 3-kinase isoforms, with p110δ and γ exhibiting specialized signaling functions in neutrophils, monocytes, mast cells, and lymphocytes. In platelets, p110β appears to be the dominant PI 3-kinase isoform regulating platelet activation, ...

journal_title：Current topics in microbiology and immunology

authors： Jackson SP,Schoenwaelder SM

更新日期：2010-01-01 00:00:00

abstract：:The surface membrane molecule CD5 is expressed on mature T cells and on the B-1a subpopulation of B cells. These CD5 positive B cells express an antibody repertoire with a relatively high frequency of self-reactivity. There is uncertainty about the origins of CD5 B cells and the reasons for this are reviewed. Recent r...

journal_title：Current topics in microbiology and immunology

authors： Bandyopadhyay RS,Teutsch MR,Wortis HH

更新日期：1995-01-01 00:00:00

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:The CBA/N strain carries xid, a murine btk missense mutation that reduces peripheral B cell numbers. Using in vivo BrdU labeling and cytofluorimetry, we have compared the magnitude, production rates, and turnover rates of each B lineage subset in the marrow and periphery of CBA/Ca and CBA/N mice. Our results show the ...

journal_title：Current topics in microbiology and immunology

authors： Cancro MP,Sah AP,Levy SL,Allman DM,Constantinescu D,Schmidt MR,Woodland RT

更新日期：2000-01-01 00:00:00

abstract：:Selected microenvironmental stimuli confer to leukemic cells a growth advantage and an extended survival. We aimed at dissecting the differential support provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence...

journal_title：Current topics in microbiology and immunology

authors： Ghia P,Circosta P,Scielzo C,Vallario A,Camporeale A,Granziero L,Caligaris-Cappio F

更新日期：2005-01-01 00:00:00