Abstract：
:There is currently a handful of genome sequences available for tailed bacteriophages with genomes of more than 200 kbp of DNA, designated here as giant or jumbo phages. The majority of the proteins predicted from the genome sequences of these phages have no matches in the current sequence databases, and the genomes themselves are diverse enough to preclude the sorts of detailed comparative analysis that has benefited study of the smaller phages, for which hundreds of genome sequences are available. However, it is informative to extrapolate the better known genome organizations and mechanisms of evolution seen in the smaller phages to the jumbo phages. In this way, we see that the jumbo phages encode the same functions as the smaller phages, supplemented with large numbers of mostly small genes of mostly undiscovered functions. A case can be made that the jumbo phages evolved from smaller tailed phages, possibly in a process mediated by the constraints imposed on genome size by capsid size.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Hendrix RWdoi
10.1007/978-3-540-68618-7_7subject
Has Abstractpub_date
2009-01-01 00:00:00pages
229-40eissn
0070-217Xissn
2196-9965journal_volume
328pub_type
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更新日期：2007-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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更新日期：2009-01-01 00:00:00
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更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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