Abstract:
:A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has been rapid progress in our understanding of how autoreactive T cell specificities are diverted into the T regulatory lineage. Here we review and highlight the recent progress in how tolerance is imposed on the developing thymocyte repertoire.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Mouchess ML,Anderson Mdoi
10.1007/82_2013_321subject
Has Abstractpub_date
2014-01-01 00:00:00pages
69-86eissn
0070-217Xissn
2196-9965journal_volume
373pub_type
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