Measles virus receptors.

abstract：:Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...

journal_title：Current topics in microbiology and immunology

authors： Baldwin MR,Barbieri JT

更新日期：2005-01-01 00:00:00

abstract：:There is a trend toward viral-based hybrid systems to furnish viral nanoparticles with enhanced features, for function beyond a delivery vehicle. Such hybrids have included Nanogold for microwave release, quantum dots and fluorescent moieties, to provide simultaneous imaging capabilities, and iron oxide particles for ...

journal_title：Current topics in microbiology and immunology

authors： Portney NG,Destito G,Manchester M,Ozkan M

更新日期：2009-01-01 00:00:00

abstract：:Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....

journal_title：Current topics in microbiology and immunology

authors： Ota T,Sitnikova T,Nei M

更新日期：2000-01-01 00:00:00

abstract：:The field of autophagy research has advanced rapidly in recent years, with important discoveries made in relation to both molecular mechanisms and physiological functions. Initially, autophagy was thought to be primarily a response to starvation. Although this might be true in lower eukaryotes, this catabolic process ...

journal_title：Current topics in microbiology and immunology

authors： Mizushima N

更新日期：2009-01-01 00:00:00

abstract：:The catalytic polypeptides of certain bacterial and plant protein toxins reach their substrates in the cytosol of mammalian cells by retro-translocation from the endoplasmic reticulum (ER). Emerging evidence indicates that these proteins subvert the ER-associated protein degradation (ERAD) pathway that normally remove...

journal_title：Current topics in microbiology and immunology

authors： Lord JM,Roberts LM,Lencer WI

更新日期：2005-01-01 00:00:00

abstract：:The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that ...

journal_title：Current topics in microbiology and immunology

authors： Lindemann D,Goepfert PA

更新日期：2003-01-01 00:00:00

abstract：:CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...

journal_title：Current topics in microbiology and immunology

authors： Tanaka H,Taniuchi I

更新日期：2014-01-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-...

journal_title：Current topics in microbiology and immunology

authors： Reyes-Robles T,Torres VJ

更新日期：2017-01-01 00:00:00

abstract：:Recent advances in inductively coupled plasma mass spectrometry (ICP-MS) as applied in mass cytometry, enabled its broad applicability to life science research. Mass cytometry enables the high-dimensional characterization of cellular systems by simultaneously measuring dozens of metal isotope reporter labeled antibodi...

journal_title：Current topics in microbiology and immunology

authors： Zivanovic N,Jacobs A,Bodenmiller B

更新日期：2014-01-01 00:00:00

abstract：:Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specif...

journal_title：Current topics in microbiology and immunology

authors： Kumar R,Amado RG

更新日期：2012-01-01 00:00:00

abstract：:By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the m...

journal_title：Current topics in microbiology and immunology

authors： Bordería AV,Rozen-Gagnon K,Vignuzzi M

更新日期：2016-01-01 00:00:00

abstract：:Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...

journal_title：Current topics in microbiology and immunology

authors： Steinman L,Utz PJ,Robinson WH

更新日期：2005-01-01 00:00:00

abstract：:The capacity of varicella zoster virus (VZV) to cause varicella (chickenpox) relies upon multiple steps, beginning with inoculation of the host at mucosal sites with infectious virus in respiratory droplets. Despite the presence of a powerful immune defense system, this virus is able to disseminate from the site of in...

journal_title：Current topics in microbiology and immunology

authors： Abendroth A,Kinchington PR,Slobedman B

更新日期：2010-01-01 00:00:00

abstract：:The low-resource environment deprives healthcare providers caring for patients with Ebola virus disease (EVD) of many of the means employed for the critically ill that are available in better resourced settings, such as advanced therapeutic interventions and abundant staff. In addition to these limitations may be adde...

journal_title：Current topics in microbiology and immunology

authors： Sprecher A,Van Herp M,Rollin PE

更新日期：2017-01-01 00:00:00

abstract：:Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also ...

journal_title：Current topics in microbiology and immunology

authors： Kline JN

更新日期：2000-01-01 00:00:00

abstract：:The collaboration between Alick Isaacs and myself started in the summer of 1956. Our initial project was to show, by electron microscopy, that interference between inactivated influenza virus and live virus involved the transfer of material from the interfering virus to the host cell. This approach failed for technica...

journal_title：Current topics in microbiology and immunology

authors： Lindenmann J

更新日期：2007-01-01 00:00:00

abstract：:DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the ho...

journal_title：Current topics in microbiology and immunology

authors： Zawilak-Pawlik A,Zakrzewska-Czerwińska J

更新日期：2017-01-01 00:00:00

abstract：:Specific T cell responses to a variety of self and microbial lipids depend on proper assembly and intracellular trafficking of CD 1 molecules that intersect with and load processed lipid antigens. These pathways involve unique membrane trafficking and chaperones that are distinct from those utilized for major histocom...

journal_title：Current topics in microbiology and immunology

authors： Sugita M,Barral DC,Brenner MB

更新日期：2007-01-01 00:00:00

abstract：:We identified a population of IgM+IgD+ B-cells in the peripheral blood (PB) of humans that express somatically mutated V-region genes like classical class switched or IgM-only memory B-cells and comprise around 15% of PB B-cells in adults. Mutated IgM+IgD+ cells differ from unmutated naive IgM+IgD+ cells in that they ...

journal_title：Current topics in microbiology and immunology

authors： Klein U,Rajewsky K,Küppers R

更新日期：1999-01-01 00:00:00

abstract：:There is currently a handful of genome sequences available for tailed bacteriophages with genomes of more than 200 kbp of DNA, designated here as giant or jumbo phages. The majority of the proteins predicted from the genome sequences of these phages have no matches in the current sequence databases, and the genomes th...

journal_title：Current topics in microbiology and immunology

authors： Hendrix RW

更新日期：2009-01-01 00:00:00

abstract：:A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has...

journal_title：Current topics in microbiology and immunology

authors： Mouchess ML,Anderson M

更新日期：2014-01-01 00:00:00

abstract：:Endemic Burkitt's lymphoma (BL) remains the most prevalent pediatric cancer in sub-Saharan Africa even though it was the first human cancer with a viral etiology described over 50 years ago. Epstein-Barr virus (EBV) was discovered in a BL tumor in 1964 and has since been implicated in other malignancies. The etiology ...

journal_title：Current topics in microbiology and immunology

authors： Rochford R,Moormann AM

更新日期：2015-01-01 00:00:00

abstract：:The use of appropriate fluorescent proteins has allowed the use of FRET microscopy for investigation of intermolecular interactions in living cells. This method has the advantage of both being dynamic and of working at the subcellular level, so that the time and place where proteins interact can be visualized. We have...

journal_title：Current topics in microbiology and immunology

authors： Gascoigne NR,Ampudia J,Clamme JP,Fu G,Lotz C,Mallaun M,Niederberger N,Palmer E,Rybakin V,Yachi PP,Zal T

更新日期：2009-01-01 00:00:00

abstract：:In this chapter, cancer research using immunodeficient mice, with emphasis on metastasis field studies, is described. The definition of "humanized mice" used for biomedical research is given in the chapter by Nomura et al. in this volume. Briefly, a humanized mouse possesses human cells or tissues and shows, in part, ...

journal_title：Current topics in microbiology and immunology

authors： Nakamura M,Suemizu H

更新日期：2008-01-01 00:00:00

abstract：:Leptospires are spirochetes that may be free-living saprophytes found in freshwater or may cause acute or chronic infection of animals. The family Leptospiraceae comprises three genera: Leptospira Leptospira Leptonema Leptonema, and Turneriella Turneriella. Within the genus Leptospira, three clades can be distinguishe...

journal_title：Current topics in microbiology and immunology

authors： Levett PN

更新日期：2015-01-01 00:00:00

abstract：:B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine sig...

journal_title：Current topics in microbiology and immunology

authors： Clark MR,Cooper AB,Wang LD,Aifantis I

更新日期：2005-01-01 00:00:00

abstract：:Production of type I IFN is the key response to viral infection. Since the discovery of type I IFNs in 1957, long double-stranded RNA formed during replication of many viruses was thought to be responsible for type I IFN induction, and for decades double-stranded RNA-activated protein kinase (PKR) was thought to be th...

journal_title：Current topics in microbiology and immunology

authors： Schlee M,Barchet W,Hornung V,Hartmann G

更新日期：2007-01-01 00:00:00

abstract：:Various gram-negative pathogens express type IV secretion systems (T4SSs) which translocate bacterial virulence factors into host target cells to hijack cellular processes for their own benefit and causing disease. The pathology of Helicobacter pylori, the causative agent of chronic gastritis, peptic ulcer disease, an...

journal_title：Current topics in microbiology and immunology

authors： Backert S,Haas R,Gerhard M,Naumann M

更新日期：2017-01-01 00:00:00

abstract：:Natural killer (NK) cells are crucial to mounting an effective immune response. They have a significant role in cancer immunosurveillance and function as a bridge between innate and adaptive immunity. However, until recently, surprisingly little was known about the molecular basis of NK cell development as compared to...

journal_title：Current topics in microbiology and immunology

authors： Male V,Brady HJ

更新日期：2014-01-01 00:00:00

abstract：:Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is hig...

journal_title：Current topics in microbiology and immunology

authors： Habenstein B,El Mammeri N,Tolchard J,Lamon G,Tawani A,Berbon M,Loquet A

更新日期：2020-01-01 00:00:00