Abstract：
:Specific T cell responses to a variety of self and microbial lipids depend on proper assembly and intracellular trafficking of CD 1 molecules that intersect with and load processed lipid antigens. These pathways involve unique membrane trafficking and chaperones that are distinct from those utilized for major histocompatibility complex (MHC)-mediated presentation of peptide antigens, and thus define unique lipid antigen presentation pathways. Furthermore, recent studies have identified components of lipid metabolism that participate in lipid delivery, uptake, processing and loading onto CD1 molecules. Defects in these pathways result in impaired T cell development and function, underscoring their critical role in the lipid-specific T cell immune responses.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Sugita M,Barral DC,Brenner MBdoi
10.1007/978-3-540-69511-0_6subject
Has Abstractpub_date
2007-01-01 00:00:00pages
143-64eissn
0070-217Xissn
2196-9965journal_volume
314pub_type
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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