Abstract:
:The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its targets points to a variety of roles for this, and other hypoxia-regulated miRNAs (HRMs), in tumour growth and survival. miR-210 expression correlates with poor survival in cancer patients, and shows promise for future use as a tumour marker or therapeutic agent. The role of miR-210 and other HRMs in cancer biology is the subject of this review.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
McCormick R,Buffa FM,Ragoussis J,Harris ALdoi
10.1007/82_2010_76subject
Has Abstractpub_date
2010-01-01 00:00:00pages
47-70eissn
0070-217Xissn
2196-9965journal_volume
345pub_type
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
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