Specialized chromatin patterns in the control of inflammatory gene expression.

abstract：:Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is hig...

journal_title：Current topics in microbiology and immunology

authors： Habenstein B,El Mammeri N,Tolchard J,Lamon G,Tawani A,Berbon M,Loquet A

更新日期：2020-01-01 00:00:00

abstract：:The Gram-negative bacterium Helicobacter pylori is predominantly known for its tight association with peptic ulcer disease and gastric cancer development. However, recent epidemiological and experimental evidence suggests that chronic infection with H. pylori may at the same time be beneficial to the host by conferrin...

journal_title：Current topics in microbiology and immunology

authors： Kyburz A,Müller A

更新日期：2017-01-01 00:00:00

abstract：:The activation and expansion of T cells in an antimicrobial immune response is based on the ability of T cell receptors (TCR) to discriminate between MHC-bound peptides derived from different microbial agents as well as self-proteins. However, the specificity of T cells is constrained by the limited number of peptide ...

journal_title：Current topics in microbiology and immunology

authors： Wucherpfennig KW

更新日期：2005-01-01 00:00:00

abstract：:Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...

journal_title：Current topics in microbiology and immunology

authors： Steinman L,Utz PJ,Robinson WH

更新日期：2005-01-01 00:00:00

abstract：:Production of type I IFN is the key response to viral infection. Since the discovery of type I IFNs in 1957, long double-stranded RNA formed during replication of many viruses was thought to be responsible for type I IFN induction, and for decades double-stranded RNA-activated protein kinase (PKR) was thought to be th...

journal_title：Current topics in microbiology and immunology

authors： Schlee M,Barchet W,Hornung V,Hartmann G

更新日期：2007-01-01 00:00:00

abstract：:The application of fundamental concepts about the packaging of the adenovirus genome has contributed significantly to the development of therapeutic viral vectors for gene therapy. The packaging of adenovirus DNA into virus particles requires a cis-acting domain at the left end of the genome. This region contains a se...

journal_title：Current topics in microbiology and immunology

authors： Ostapchuk P,Hearing P

更新日期：2003-01-01 00:00:00

abstract：:Interleukin (IL)-22 is a member of the IL-10 family of cytokines, which, besides IL-10, contains seven additional cytokines. Although the founding member IL-10 is an important immunoregulatory cytokine that represses both innate and adaptive immunity, the other family members preferentially target epithelial cells and...

journal_title：Current topics in microbiology and immunology

authors： Eidenschenk C,Rutz S,Liesenfeld O,Ouyang W

更新日期：2014-01-01 00:00:00

abstract：:The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that ...

journal_title：Current topics in microbiology and immunology

authors： Lindemann D,Goepfert PA

更新日期：2003-01-01 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen, responsible for infections in the community and the healthcare setting. Although much of the attention is focused on the methicillin-resistant "variant" MRSA, the methicillin-susceptible counterpart (MSSA) remains a prime species in infections. The epidemiology of ...

journal_title：Current topics in microbiology and immunology

authors： Monaco M,Pimentel de Araujo F,Cruciani M,Coccia EM,Pantosti A

更新日期：2017-01-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets ( Paguma larvata), togethe...

journal_title：Current topics in microbiology and immunology

authors： Wang LF,Eaton BT

更新日期：2007-01-01 00:00:00

abstract：:Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization. Several key fact...

journal_title：Current topics in microbiology and immunology

authors： Beloin C,Roux A,Ghigo JM

更新日期：2008-01-01 00:00:00

abstract：:The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants. HDV ribozymes have provided a tractable system fo...

journal_title：Current topics in microbiology and immunology

authors： Been MD

更新日期：2006-01-01 00:00:00

abstract：:Collective knowledge regarding the occurrence of influenza among swine is incomplete due to inconsistent surveillance of swine populations. In this chapter, we review what surveillance activities exist and some of the practical challenges encountered. Furthermore, to support robust surveillance activities, accurate la...

journal_title：Current topics in microbiology and immunology

authors： Detmer S,Gramer M,Goyal S,Torremorell M,Torrison J

更新日期：2013-01-01 00:00:00

abstract：:Most eukaryotic messenger RNAs are transcribed as precursors that necessitate specific and exact processing of intron boundaries. Furthermore, the choice of these boundaries appears to be fluid and adaptive to the rate of transcription and the developmental and physiological state of the cell. A central regulator of s...

journal_title：Current topics in microbiology and immunology

authors： Fluhr R

更新日期：2008-01-01 00:00:00

abstract：:B. anthracis virulence is the sum of the contributions of factors involved in toxicity, growth and persistence in the host. Recent data has revealed that the interactions between B. anthracis and macrophage is central to the B. anthracis pathogenesis. This review presents and describes tactics by which B. anthracis no...

journal_title：Current topics in microbiology and immunology

authors： Guidi-Rontani C,Mock M

更新日期：2002-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00

abstract：:Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also ...

journal_title：Current topics in microbiology and immunology

authors： Kline JN

更新日期：2000-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of ...

journal_title：Current topics in microbiology and immunology

authors： Pickles RJ

更新日期：2013-01-01 00:00:00

abstract：:Torque teno (TT) viruses have been more frequently reported in malignant biopsies when compared to normal control tissue. The possible contribution of TT virus infection to human carcinogenesis or the potential oncolytic functions of these virus infections are being discussed based on available experimental evidence. ...

journal_title：Current topics in microbiology and immunology

authors： zur Hausen H,de Villiers EM

更新日期：2009-01-01 00:00:00

abstract：:Enzootic nasal adenocarcinoma is a contagious tumour of the mucosal nasal glands affecting young adult sheep or goats. The disease occurs naturally in all continents except Australia and New Zealand. Clinical signs include continuous nasal discharge, respiratory distress, exophthalmos and skull deformations. The tumou...

journal_title：Current topics in microbiology and immunology

authors： De las Heras M,Ortín A,Cousens C,Minguijón E,Sharp JM

更新日期：2003-01-01 00:00:00

abstract：:Protein synthesis requires nutrients both as precursors (amino acids) and as a source of energy, since this process consumes a high proportion of cellular metabolic energy. Recent work has shown that both types of nutrients directly influence the activities of components of the translational machinery in mammalian cel...

journal_title：Current topics in microbiology and immunology

authors： Proud CG

更新日期：2004-01-01 00:00:00

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine sig...

journal_title：Current topics in microbiology and immunology

authors： Clark MR,Cooper AB,Wang LD,Aifantis I

更新日期：2005-01-01 00:00:00

abstract：:There is a trend toward viral-based hybrid systems to furnish viral nanoparticles with enhanced features, for function beyond a delivery vehicle. Such hybrids have included Nanogold for microwave release, quantum dots and fluorescent moieties, to provide simultaneous imaging capabilities, and iron oxide particles for ...

journal_title：Current topics in microbiology and immunology

authors： Portney NG,Destito G,Manchester M,Ozkan M

更新日期：2009-01-01 00:00:00

abstract：:The fibroblast growth factor (FGF) family contains 23 members in mammals including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation of many key cellular responses involved in developmental and physiological processes. These includes proliferation, differentiation, migration, apoptosis, an...

journal_title：Current topics in microbiology and immunology

authors： Wiedłocha A,Sørensen V

更新日期：2004-01-01 00:00:00

abstract：:Our incomplete understanding of the mechanisms that orchestrate human lymphocyte differentiation and condition human immune responses is in part due to the limited access to normal human tissue samples that can inform on these complex processes. In addition, in vitro culture conditions fail to recapitulate the three-d...

journal_title：Current topics in microbiology and immunology

authors： Li Y,Di Santo JP

更新日期：2016-01-01 00:00:00

abstract：:Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts. While most evidence still supports this dogma, recent studies in bats have suggested other reservoir species may also exist. Extensive ...

journal_title：Current topics in microbiology and immunology

authors： Yoon SW,Webby RJ,Webster RG

更新日期：2014-01-01 00:00:00

abstract：:Influenza hemagglutinin (HA) is the major surface glycoprotein on influenza viruses and mediates viral attachment and subsequent fusion with host cells. The HA is the major target of the immune response, but due to its high level of variability, as evidenced by substantial antigenic diversity, it had been historically...

journal_title：Current topics in microbiology and immunology

authors： Lee PS,Wilson IA

更新日期：2015-01-01 00:00:00

abstract：:The surface membrane molecule CD5 is expressed on mature T cells and on the B-1a subpopulation of B cells. These CD5 positive B cells express an antibody repertoire with a relatively high frequency of self-reactivity. There is uncertainty about the origins of CD5 B cells and the reasons for this are reviewed. Recent r...

journal_title：Current topics in microbiology and immunology

authors： Bandyopadhyay RS,Teutsch MR,Wortis HH

更新日期：1995-01-01 00:00:00

abstract：:The family of protein tyrosine phosphatases (PTPs) includes 107 genes in humans that are diverse in their structures and expression profiles. The majority are present in immune cells and play various roles in either inhibiting or promoting the duration and amplitude of signaling cascades. Several PTPs, including TC-PT...

journal_title：Current topics in microbiology and immunology

authors： Penafuerte C,Perez-Quintero LA,Vinette V,Hatzihristidis T,Tremblay ML

更新日期：2017-01-01 00:00:00