Abstract:
:The fibroblast growth factor (FGF) family contains 23 members in mammals including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation of many key cellular responses involved in developmental and physiological processes. These includes proliferation, differentiation, migration, apoptosis, angiogenesis, and wound healing. FGFs bind to five related, specific cell surface receptors (FGFRs). Four of these have intrinsic tyrosine kinase activity. Dimerization of the receptor is a prerequisite for receptor transphosphorylation and activation of downstream signaling molecules. All members of the FGF family have a high affinity for heparin and for cell surface heparan sulfate proteoglycans, which participate in formation of stable and active FGF-FGFR complexes. FGF-mediated signaling is an evolutionarily conserved signaling module operative in invertebrates and vertebrates. It seems that some members of the family have a dual mode of action. FGF-1, FGF-2, FGF-3, and FGF-11-14 have been found intranuclearly as endogenous proteins. Exogenous FGF-1 and FGF-2 are internalized by receptor-mediated endocytosis, in a clathrin-dependent and -independent way. Internalized FGF-1 and FGF-2 are able to cross cellular membranes to reach the cytosol and the nuclear compartment. The role of FGF internalization and the intracellular activity of some FGFs are discussed in the context of the known signaling induced by FGF.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Wiedłocha A,Sørensen Vdoi
10.1007/978-3-540-69494-6_3subject
Has Abstractpub_date
2004-01-01 00:00:00pages
45-79eissn
0070-217Xissn
2196-9965journal_volume
286pub_type
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journal_title:Current topics in microbiology and immunology
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doi:
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abstract::Imprinting is the uniparental expression of a set of genes. Somatic cells carry two haploid sets of chromosomes, one maternal and one paternal, while germ cells contain only one of the two forms of chromosomes, male or female. This implies that during early embryogenesis the cells committed for developing the future g...
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
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doi:10.1007/978-3-642-55541-1_2
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-28007-3_7
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abstract::The capacity of varicella zoster virus (VZV) to cause varicella (chickenpox) relies upon multiple steps, beginning with inoculation of the host at mucosal sites with infectious virus in respiratory droplets. Despite the presence of a powerful immune defense system, this virus is able to disseminate from the site of in...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2019_162
更新日期:2019-01-01 00:00:00
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_274
更新日期:2013-01-01 00:00:00
abstract::Glucans are characteristic and major constituents of fungal cell walls. Depending on the species, different glucan polysaccharides can be found. These differ in the linkage of the D-glucose monomers which can be either in α- or β-conformation and form 1,3, 1,4 or 1,6 O-glycosidic bonds. The linkages and polymer length...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2020_200
更新日期:2020-01-01 00:00:00
abstract::Protein synthesis requires nutrients both as precursors (amino acids) and as a source of energy, since this process consumes a high proportion of cellular metabolic energy. Recent work has shown that both types of nutrients directly influence the activities of components of the translational machinery in mammalian cel...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-18930-2_13
更新日期:2004-01-01 00:00:00
abstract::The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely thos...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-32952-8_8
更新日期:2006-01-01 00:00:00
abstract::Picornavirus 5' NCRs contain IRES elements that have been divided into two groups, exemplified by PV (type 1) and EMCV (type 2). These elements are functionally related and have an intriguing level of structural and sequence similarity. Some conserved RNA sequences and/or structures may correspond to cis-acting elemen...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-79663-0_2
更新日期:1995-01-01 00:00:00
abstract::Most eukaryotic messenger RNAs are transcribed as precursors that necessitate specific and exact processing of intron boundaries. Furthermore, the choice of these boundaries appears to be fluid and adaptive to the rate of transcription and the developmental and physiological state of the cell. A central regulator of s...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-76776-3_7
更新日期:2008-01-01 00:00:00
abstract::Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assemb...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-75157-1_4
更新日期:2008-01-01 00:00:00
abstract::Commercial vaccines currently available against swine influenza virus (SIV) are inactivated, adjuvanted, whole virus vaccines, based on H1N1 and/or H3N2 and/or H1N2 SIVs. In keeping with the antigenic and genetic differences between SIVs circulating in Europe and the US, the vaccines for each region are produced local...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_266
更新日期:2013-01-01 00:00:00
abstract::During early stages of development, precursor B lymphocytes express a characteristic type of antigen receptor known as the pre-B-cell receptor (pre-BCR). This receptor differs from conventional BCRs in that it possesses a germ line-encoded surrogate light chain (SLC), which is associated with the signal transduction m...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2015_475
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abstract::The CBA/N strain carries xid, a murine btk missense mutation that reduces peripheral B cell numbers. Using in vivo BrdU labeling and cytofluorimetry, we have compared the magnitude, production rates, and turnover rates of each B lineage subset in the marrow and periphery of CBA/Ca and CBA/N mice. Our results show the ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/978-3-642-57284-5_4
更新日期:2000-01-01 00:00:00
abstract::Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-27511-8_8
更新日期:2005-01-01 00:00:00
abstract::Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-59672-8_15
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abstract::Hemopoietic cells express relatively high levels of the type I phosphoinositide (PI) 3-kinase isoforms, with p110δ and γ exhibiting specialized signaling functions in neutrophils, monocytes, mast cells, and lymphocytes. In platelets, p110β appears to be the dominant PI 3-kinase isoform regulating platelet activation, ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::Autoimmune gastritis (AIG) is an experimental model that closely resembles human autoimmune gastritis, the underlying pathology of pernicious anemia. Pathogenic CD4+ T cells are reactive to the parietal cell autoantigen, H/K ATPase, and are controlled by CD4+CD25+ T cells in an immunosuppressive cytokine-independent m...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-27702-1_8
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abstract::E2F is a heterodimer composed of two partners, such as E2F1 and DP1. Although E2F1 can bind DNA as a homodimer and increase promoter activity, optimal DNA-binding and transcriptional activity occurs in the heterodimeric form. A model (Fig. 3) for the involvement of E2F activity in cell growth control that incorporates...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-79910-5_1
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abstract::Human cytomegalovirus (HCMV) has evolved numerous strategies to commandeer the host cell for producing viral progeny. The virus manipulates host cell cycle pathways from the early stages of infection to stimulate viral DNA replication at the expense of cellular DNA synthesis. At the same time, cell cycle checkpoints a...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets ( Paguma larvata), togethe...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-70962-6_13
更新日期:2007-01-01 00:00:00
abstract::Cell-based therapies with various lymphocytes and antigen-presenting cells are promising approaches for cancer immunotherapy. The transfusion of T lymphocytes, also called adoptive cell therapy (ACT), is an effective treatment for viral infections, has induced regression of cancer in early stage clinical trials, and m...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2010_94
更新日期:2011-01-01 00:00:00
abstract::NF-κB is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. The activity of NF-κB is tightly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase, which phosphorylates...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2010_108
更新日期:2011-01-01 00:00:00