Burkitt's Lymphoma.

abstract：:Leptospires are spirochetes that may be free-living saprophytes found in freshwater or may cause acute or chronic infection of animals. The family Leptospiraceae comprises three genera: Leptospira Leptospira Leptonema Leptonema, and Turneriella Turneriella. Within the genus Leptospira, three clades can be distinguishe...

journal_title：Current topics in microbiology and immunology

authors： Levett PN

更新日期：2015-01-01 00:00:00

abstract：:Rabies, being a major zoonotic disease, significantly impacts global public health. It is invariably fatal once clinical signs are apparent. The majority of human rabies deaths occur in developing countries. India alone reports more than 50% of the global rabies deaths. Although it is a vaccine-preventable disease, ef...

journal_title：Current topics in microbiology and immunology

authors： Nagarajan T,Rupprecht CE,Dessain SK,Rangarajan PN,Thiagarajan D,Srinivasan VA

更新日期：2008-01-01 00:00:00

abstract：:The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments includ...

journal_title：Current topics in microbiology and immunology

authors： Hendriks A,Cruz AR,Soldaini E,Manetti AGO,Bagnoli F

更新日期：2018-09-20 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...

journal_title：Current topics in microbiology and immunology

authors： Chandrahas VK,Han J,Kaufman RJ

更新日期：2018-01-01 00:00:00

abstract：:The incidence of Kaposi sarcoma (KS) related to Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) after organ transplantation is 500-1000 times greater than in the general population, and its occurrence is associated with immunosuppressive therapy. The reported incidence of posttransplant KS ranges from 0.5% to 5%, d...

journal_title：Current topics in microbiology and immunology

authors： Marcelin AG,Calvez V,Dussaix E

更新日期：2007-01-01 00:00:00

abstract：:The catalytic polypeptides of certain bacterial and plant protein toxins reach their substrates in the cytosol of mammalian cells by retro-translocation from the endoplasmic reticulum (ER). Emerging evidence indicates that these proteins subvert the ER-associated protein degradation (ERAD) pathway that normally remove...

journal_title：Current topics in microbiology and immunology

authors： Lord JM,Roberts LM,Lencer WI

更新日期：2005-01-01 00:00:00

abstract：:T cell activation begins with the interaction between an antigen-specific T cell and an antigen-presenting cell (APC). This interaction results in the formation of the immunological synapse, which had been considered to be responsible for antigen recognition and T cell activation. Recent advances in imaging analysis h...

journal_title：Current topics in microbiology and immunology

authors： Yokosuka T,Saito T

更新日期：2010-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of ...

journal_title：Current topics in microbiology and immunology

authors： Pickles RJ

更新日期：2013-01-01 00:00:00

abstract：:Single-cell technologies like mass cytometry enable researchers to comprehensively monitor signaling network responses in the context of heterogeneous cell populations. Cell-to-cell variability, the possibly nonlinear topology of signaling processes, and the destructive nature of mass cytometry necessitate nontrivial ...

journal_title：Current topics in microbiology and immunology

authors： Claassen M

更新日期：2014-01-01 00:00:00

abstract：:Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also ...

journal_title：Current topics in microbiology and immunology

authors： Kline JN

更新日期：2000-01-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-...

journal_title：Current topics in microbiology and immunology

authors： Reyes-Robles T,Torres VJ

更新日期：2017-01-01 00:00:00

abstract：:Naturally arising CD25+CD4+ regulatory T cells, which express the transcription factor Foxp3, play key roles in the maintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological immune responses. The majority of them are produced by the normal thymus as a functionally ma...

journal_title：Current topics in microbiology and immunology

authors： Sakaguchi S,Setoguchi R,Yagi H,Nomura T

更新日期：2006-01-01 00:00:00

abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...

journal_title：Current topics in microbiology and immunology

authors： Gosztonyi G,Ludwig H

更新日期：1995-01-01 00:00:00

abstract：:A number of Gram-positive bacteria are important players in industry as producers of a diverse array of economically interesting metabolites and proteins. As discussed in this overview, several Gram-positive bacteria are valuable hosts for the production of heterologous proteins. In contrast to Gram-negative bacteria,...

journal_title：Current topics in microbiology and immunology

authors： Anné J,Economou A,Bernaerts K

更新日期：2017-01-01 00:00:00

abstract：:Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusivelywith the un...

journal_title：Current topics in microbiology and immunology

authors： Jones PL,Shi YB

更新日期：2003-01-01 00:00:00

abstract：:Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. I...

journal_title：Current topics in microbiology and immunology

authors： Kubagawa H,Skopnik CM,Zimmermann J,Durek P,Chang HD,Yoo E,Bertoli LF,Honjo K,Radbruch A

更新日期：2017-01-01 00:00:00

abstract：:The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mit...

journal_title：Current topics in microbiology and immunology

authors： Wilson BA,Ho M

更新日期：2012-01-01 00:00:00

abstract：:Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...

journal_title：Current topics in microbiology and immunology

authors： Mori Y,Sadaoka T

更新日期：2010-01-01 00:00:00

abstract：:Poxviruses have been long regarded as potent inhibitors of apoptotic cell death. More recently, they have been shown to inhibit necroptotic cell death through two distinct strategies. These strategies involve either blocking virus sensing by the host pattern recognition receptor, ZBP1 (also called DAI) or by influenci...

journal_title：Current topics in microbiology and immunology

authors： Koehler HS,Jacobs BL

更新日期：2021-01-29 00:00:00

abstract：:The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the ami...

journal_title：Current topics in microbiology and immunology

authors： Amoasii L,Hnia K,Laporte J

更新日期：2012-01-01 00:00:00

abstract：:Influenza vaccines are the mainstay of efforts to reduce the substantial health burden from seasonal influenza. Inactivated influenza vaccines have been available since the 1940s and are administered via intramuscular injection. Inactivated vaccines can be given to anyone six months of age or older. Live attenuated, c...

journal_title：Current topics in microbiology and immunology

authors： Fiore AE,Bridges CB,Cox NJ

更新日期：2009-01-01 00:00:00

abstract：:Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompany...

journal_title：Current topics in microbiology and immunology

authors： Owens T

更新日期：2009-01-01 00:00:00

abstract：:Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively...

journal_title：Current topics in microbiology and immunology

authors： Hayes JM,Cosgrave EF,Struwe WB,Wormald M,Davey GP,Jefferis R,Rudd PM

更新日期：2014-01-01 00:00:00

abstract：:Hemopoietic cells express relatively high levels of the type I phosphoinositide (PI) 3-kinase isoforms, with p110δ and γ exhibiting specialized signaling functions in neutrophils, monocytes, mast cells, and lymphocytes. In platelets, p110β appears to be the dominant PI 3-kinase isoform regulating platelet activation, ...

journal_title：Current topics in microbiology and immunology

authors： Jackson SP,Schoenwaelder SM

更新日期：2010-01-01 00:00:00

abstract：:By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the m...

journal_title：Current topics in microbiology and immunology

authors： Bordería AV,Rozen-Gagnon K,Vignuzzi M

更新日期：2016-01-01 00:00:00

abstract：:Despite the wealth of data describing the ecological factors that underpin viral emergence, little is known about the evolutionary processes that allow viruses to jump species barriers and establish productive infections in new hosts. Understanding the evolutionary basis to virus emergence is therefore a key research ...

journal_title：Current topics in microbiology and immunology

authors： Holmes EC,Drummond AJ

更新日期：2007-01-01 00:00:00

abstract：:The CBA/N strain carries xid, a murine btk missense mutation that reduces peripheral B cell numbers. Using in vivo BrdU labeling and cytofluorimetry, we have compared the magnitude, production rates, and turnover rates of each B lineage subset in the marrow and periphery of CBA/Ca and CBA/N mice. Our results show the ...

journal_title：Current topics in microbiology and immunology

authors： Cancro MP,Sah AP,Levy SL,Allman DM,Constantinescu D,Schmidt MR,Woodland RT

更新日期：2000-01-01 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell,...

journal_title：Current topics in microbiology and immunology

authors： Skoberne M,Beignon AS,Larsson M,Bhardwaj N

更新日期：2005-01-01 00:00:00