Varicella-zoster virus glycoprotein M.

abstract：:Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-...

journal_title：Current topics in microbiology and immunology

authors： Reyes-Robles T,Torres VJ

更新日期：2017-01-01 00:00:00

abstract：:The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...

journal_title：Current topics in microbiology and immunology

authors： Tracy S,Chapman NM,Drescher KM,Kono K,Tapprich W

更新日期：2006-01-01 00:00:00

abstract：:The prototypes of the human MYC and RAF gene families are orthologs of animal proto-oncogenes that were originally identified as transduced alleles in the genomes of highly oncogenic retroviruses. MYC and RAF genes are now established as key regulatory elements in normal cellular physiology, but also as major cancer d...

journal_title：Current topics in microbiology and immunology

authors： Stefan E,Bister K

更新日期：2017-01-01 00:00:00

abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...

journal_title：Current topics in microbiology and immunology

authors： Moss WJ

更新日期：2009-01-01 00:00:00

abstract：:Primary varicella-zoster virus (VZV) infection (varicella) induces VZV-specific antibody and VZV-specific T cell-mediated immunity. T cell-mediated immunity, which is detected within 1-2 weeks after appearance of rash, and consists of both CD4 and CD8 effector and memory T cells, is essential for recovery from varicel...

journal_title：Current topics in microbiology and immunology

authors： Weinberg A,Levin MJ

更新日期：2010-01-01 00:00:00

abstract：:Autoimmune gastritis (AIG) is an experimental model that closely resembles human autoimmune gastritis, the underlying pathology of pernicious anemia. Pathogenic CD4+ T cells are reactive to the parietal cell autoantigen, H/K ATPase, and are controlled by CD4+CD25+ T cells in an immunosuppressive cytokine-independent m...

journal_title：Current topics in microbiology and immunology

authors： McHugh RS

更新日期：2005-01-01 00:00:00

abstract：:Tumors are formed following the accumulation of several genetic changes in genes which normally function to regulate cell growth. As yet it is unclear why multiple mutations are required, which type of alterations can collaborate with each other, and if collaboration is cell-type specific. In our myc transgenic mouse ...

journal_title：Current topics in microbiology and immunology

authors： Scheuermann RH,Bauer SR

更新日期：1992-01-01 00:00:00

abstract：:Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively...

journal_title：Current topics in microbiology and immunology

authors： Hayes JM,Cosgrave EF,Struwe WB,Wormald M,Davey GP,Jefferis R,Rudd PM

更新日期：2014-01-01 00:00:00

abstract：:Recent advances in inductively coupled plasma mass spectrometry (ICP-MS) as applied in mass cytometry, enabled its broad applicability to life science research. Mass cytometry enables the high-dimensional characterization of cellular systems by simultaneously measuring dozens of metal isotope reporter labeled antibodi...

journal_title：Current topics in microbiology and immunology

authors： Zivanovic N,Jacobs A,Bodenmiller B

更新日期：2014-01-01 00:00:00

abstract：:A number of Gram-positive bacteria are important players in industry as producers of a diverse array of economically interesting metabolites and proteins. As discussed in this overview, several Gram-positive bacteria are valuable hosts for the production of heterologous proteins. In contrast to Gram-negative bacteria,...

journal_title：Current topics in microbiology and immunology

authors： Anné J,Economou A,Bernaerts K

更新日期：2017-01-01 00:00:00

abstract：:Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts. While most evidence still supports this dogma, recent studies in bats have suggested other reservoir species may also exist. Extensive ...

journal_title：Current topics in microbiology and immunology

authors： Yoon SW,Webby RJ,Webster RG

更新日期：2014-01-01 00:00:00

abstract：:The "humanized mouse" is a mouse harboring functioning human tissues used as in vivo human models for both physiological and pathological conditions. The NOD/Shi-scid IL2rgamma(null) (NOG) mouse, an excellent immunodeficient mouse used as the basis for the humanized mouse, requires strict genetic and environmental con...

journal_title：Current topics in microbiology and immunology

authors： Nomura T,Tamaoki N,Takakura A,Suemizu H

更新日期：2008-01-01 00:00:00

abstract：:Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine available. The development of safe GAS vaccines is challenging, researchers are confronted with obstacles such as the occurrence of many unique serotypes (there are greater than 150 M types), antigenic variation within the same serotype,...

journal_title：Current topics in microbiology and immunology

authors： Henningham A,Gillen CM,Walker MJ

更新日期：2013-01-01 00:00:00

abstract：:The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that ...

journal_title：Current topics in microbiology and immunology

authors： Lindemann D,Goepfert PA

更新日期：2003-01-01 00:00:00

abstract：:Our incomplete understanding of the mechanisms that orchestrate human lymphocyte differentiation and condition human immune responses is in part due to the limited access to normal human tissue samples that can inform on these complex processes. In addition, in vitro culture conditions fail to recapitulate the three-d...

journal_title：Current topics in microbiology and immunology

authors： Li Y,Di Santo JP

更新日期：2016-01-01 00:00:00

abstract：:The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described ...

journal_title：Current topics in microbiology and immunology

authors： Refsland EW,Harris RS

更新日期：2013-01-01 00:00:00

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways u...

journal_title：Current topics in microbiology and immunology

authors： Böhm S,Kao D,Nimmerjahn F

更新日期：2014-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of ...

journal_title：Current topics in microbiology and immunology

authors： Pickles RJ

更新日期：2013-01-01 00:00:00

abstract：:Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompany...

journal_title：Current topics in microbiology and immunology

authors： Owens T

更新日期：2009-01-01 00:00:00

abstract：:The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mit...

journal_title：Current topics in microbiology and immunology

authors： Wilson BA,Ho M

更新日期：2012-01-01 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00

abstract：:CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...

journal_title：Current topics in microbiology and immunology

authors： Tanaka H,Taniuchi I

更新日期：2014-01-01 00:00:00

abstract：:The collaboration between Alick Isaacs and myself started in the summer of 1956. Our initial project was to show, by electron microscopy, that interference between inactivated influenza virus and live virus involved the transfer of material from the interfering virus to the host cell. This approach failed for technica...

journal_title：Current topics in microbiology and immunology

authors： Lindenmann J

更新日期：2007-01-01 00:00:00

abstract：:Picornavirus 5' NCRs contain IRES elements that have been divided into two groups, exemplified by PV (type 1) and EMCV (type 2). These elements are functionally related and have an intriguing level of structural and sequence similarity. Some conserved RNA sequences and/or structures may correspond to cis-acting elemen...

journal_title：Current topics in microbiology and immunology

authors： Hellen CU,Wimmer E

更新日期：1995-01-01 00:00:00

abstract：:Hemopoietic cells express relatively high levels of the type I phosphoinositide (PI) 3-kinase isoforms, with p110δ and γ exhibiting specialized signaling functions in neutrophils, monocytes, mast cells, and lymphocytes. In platelets, p110β appears to be the dominant PI 3-kinase isoform regulating platelet activation, ...

journal_title：Current topics in microbiology and immunology

authors： Jackson SP,Schoenwaelder SM

更新日期：2010-01-01 00:00:00

abstract：:After infection of a cell, the positive-strand RNA genome of Hepatitis C Virus (HCV) directly serves as the template for translation in the cytosol. By the use of an internal ribosome entry site (IRES) element in the 5'-untranslated region (5'-UTR) of the viral RNA, the HCV RNA bypasses the need for nuclear processing...

journal_title：Current topics in microbiology and immunology

authors： Niepmann M

更新日期：2013-01-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth muscle cells are the predominant targets for virus ...

journal_title：Current topics in microbiology and immunology

authors： Sinzger C,Digel M,Jahn G

更新日期：2008-01-01 00:00:00

abstract：:Most eukaryotic messenger RNAs are transcribed as precursors that necessitate specific and exact processing of intron boundaries. Furthermore, the choice of these boundaries appears to be fluid and adaptive to the rate of transcription and the developmental and physiological state of the cell. A central regulator of s...

journal_title：Current topics in microbiology and immunology

authors： Fluhr R

更新日期：2008-01-01 00:00:00

abstract：:There is currently a handful of genome sequences available for tailed bacteriophages with genomes of more than 200 kbp of DNA, designated here as giant or jumbo phages. The majority of the proteins predicted from the genome sequences of these phages have no matches in the current sequence databases, and the genomes th...

journal_title：Current topics in microbiology and immunology

authors： Hendrix RW

更新日期：2009-01-01 00:00:00