Abstract：
:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of how RSV causes airway disease and greatly limited the development of therapeutic strategies for reducing RSV disease burden. Our current knowledge of RSV infection and pathology is largely based on in vitro studies using nonpolarized epithelial cell-lines grown on plastic or in vivo studies using animal models semipermissive for RSV infection. Although these models have revealed important aspects of RSV infection, replication, and associated inflammatory responses, these models do not broadly recapitulate the early interactions and potential consequences of RSV infection of the human columnar airway epithelium in vivo. In this chapter, the pro et contra of in vitro models of human columnar airway epithelium and their usefulness in respiratory virus pathogenesis and vaccine development studies will be discussed. The use of such culture models to predict characteristics of RSV infection and the correlation of these findings to the human in vivo situation will likely accelerate our understanding of RSV pathogenesis potentially identifying novel strategies for limiting the severity of RSV-associated airway disease.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Pickles RJdoi
10.1007/978-3-642-38919-1_19subject
Has Abstractpub_date
2013-01-01 00:00:00pages
371-87eissn
0070-217Xissn
2196-9965journal_volume
372pub_type
杂志文章abstract：:The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways u...
journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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更新日期：2013-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
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更新日期：2007-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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更新日期：2010-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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更新日期：2012-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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更新日期：2008-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
