Role of complement receptors CD21/CD35 in B lymphocyte activation and survival.

abstract：:B. anthracis virulence is the sum of the contributions of factors involved in toxicity, growth and persistence in the host. Recent data has revealed that the interactions between B. anthracis and macrophage is central to the B. anthracis pathogenesis. This review presents and describes tactics by which B. anthracis no...

journal_title：Current topics in microbiology and immunology

authors： Guidi-Rontani C,Mock M

更新日期：2002-01-01 00:00:00

abstract：:Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusivelywith the un...

journal_title：Current topics in microbiology and immunology

authors： Jones PL,Shi YB

更新日期：2003-01-01 00:00:00

abstract：:The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...

journal_title：Current topics in microbiology and immunology

authors： Tracy S,Chapman NM,Drescher KM,Kono K,Tapprich W

更新日期：2006-01-01 00:00:00

abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...

journal_title：Current topics in microbiology and immunology

authors： Moss WJ

更新日期：2009-01-01 00:00:00

abstract：:Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis (Mtb) and represents one of the most relevant bacterial diseases worldwide. Recent advances have yielded new insights into the molecular basis of the immune response required for restriction of the pathogen and also highlighted determinants of im...

journal_title：Current topics in microbiology and immunology

authors： Ablasser A,Dorhoi A

更新日期：2016-01-01 00:00:00

abstract：:CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...

journal_title：Current topics in microbiology and immunology

authors： Tanaka H,Taniuchi I

更新日期：2014-01-01 00:00:00

abstract：:Primary varicella-zoster virus (VZV) infection (varicella) induces VZV-specific antibody and VZV-specific T cell-mediated immunity. T cell-mediated immunity, which is detected within 1-2 weeks after appearance of rash, and consists of both CD4 and CD8 effector and memory T cells, is essential for recovery from varicel...

journal_title：Current topics in microbiology and immunology

authors： Weinberg A,Levin MJ

更新日期：2010-01-01 00:00:00

abstract：:Poxviruses have been long regarded as potent inhibitors of apoptotic cell death. More recently, they have been shown to inhibit necroptotic cell death through two distinct strategies. These strategies involve either blocking virus sensing by the host pattern recognition receptor, ZBP1 (also called DAI) or by influenci...

journal_title：Current topics in microbiology and immunology

authors： Koehler HS,Jacobs BL

更新日期：2021-01-29 00:00:00

abstract：:The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses with genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms. These dynamic and highly organized...

journal_title：Current topics in microbiology and immunology

authors： Patton JT,Silvestri LS,Tortorici MA,Vasquez-Del Carpio R,Taraporewala ZF

更新日期：2006-01-01 00:00:00

abstract：:Phosphoinositide 3-kinases (PI 3-kinases) are activated by growth factor and hormone receptors, and regulate cell growth, survival, motility, and responses to changes in nutritional conditions (Engelman et al. 2006). PI 3-kinases have been classified according to their subunit composition and their substrate specifici...

journal_title：Current topics in microbiology and immunology

authors： Backer JM

更新日期：2010-01-01 00:00:00

abstract：:Swine influenza is a continual problem for the Swine industry and can pose a public health threat as evidenced by the 2009 H1N1 influenza virus pandemic. Given its importance, it is not surprising to find papers describing the disease from the early 20th century. In this chapter, we discuss the history of Swine influe...

journal_title：Current topics in microbiology and immunology

authors： Schultz-Cherry S,Olsen CW,Easterday BC

更新日期：2013-01-01 00:00:00

abstract：:Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....

journal_title：Current topics in microbiology and immunology

authors： Ota T,Sitnikova T,Nei M

更新日期：2000-01-01 00:00:00

abstract：:By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the m...

journal_title：Current topics in microbiology and immunology

authors： Bordería AV,Rozen-Gagnon K,Vignuzzi M

更新日期：2016-01-01 00:00:00

abstract：:The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways u...

journal_title：Current topics in microbiology and immunology

authors： Böhm S,Kao D,Nimmerjahn F

更新日期：2014-01-01 00:00:00

abstract：:Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompany...

journal_title：Current topics in microbiology and immunology

authors： Owens T

更新日期：2009-01-01 00:00:00

abstract：:Specific T cell responses to a variety of self and microbial lipids depend on proper assembly and intracellular trafficking of CD 1 molecules that intersect with and load processed lipid antigens. These pathways involve unique membrane trafficking and chaperones that are distinct from those utilized for major histocom...

journal_title：Current topics in microbiology and immunology

authors： Sugita M,Barral DC,Brenner MB

更新日期：2007-01-01 00:00:00

abstract：:Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...

journal_title：Current topics in microbiology and immunology

authors： Mori Y,Sadaoka T

更新日期：2010-01-01 00:00:00

abstract：:Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. I...

journal_title：Current topics in microbiology and immunology

authors： Kubagawa H,Skopnik CM,Zimmermann J,Durek P,Chang HD,Yoo E,Bertoli LF,Honjo K,Radbruch A

更新日期：2017-01-01 00:00:00

abstract：:Axonal transport ensures long-range delivery of essential components and signals between proximal and distal areas of the neuron, and it is crucial for neuronal homeostasis and survival. Several pathogens and virulence factors use this route to gain access to the central nervous system, exploiting the complex and stil...

journal_title：Current topics in microbiology and immunology

authors： Bercsenyi K,Giribaldi F,Schiavo G

更新日期：2013-01-01 00:00:00

abstract：:Phospholipases are diverse enzymes produced in eukaryotic hosts and their bacterial pathogens. Several pathogen phospholipases have been identified as major virulence factors acting mainly in two different modes: on the one hand, they have the capability to destroy host membranes and on the other hand they are able to...

journal_title：Current topics in microbiology and immunology

authors： Kuhle K,Flieger A

更新日期：2013-01-01 00:00:00

abstract：:As the largest RNA virus, coronavirus replication employs complex mechanisms and involves various viral and cellular proteins. The first open reading frame of the coronavirus genome encodes a large polyprotein, which is processed into a number of viral proteins required for viral replication directly or indirectly. Th...

journal_title：Current topics in microbiology and immunology

authors： Shi ST,Lai MM

更新日期：2005-01-01 00:00:00

abstract：:This chapter highlights the cholera situation in South Asia and the Bay of Bengal region, the original 'homeland' of cholera. A detailed discussion of cholera outbreaks in individual countries in South-East Asia follows. The countries of the World Health Organization (WHO) SEARO (South-East Asia Region) region are dis...

journal_title：Current topics in microbiology and immunology

authors： Bharati K,Bhattacharya SK

更新日期：2014-01-01 00:00:00

abstract：:The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma ...

journal_title：Current topics in microbiology and immunology

authors： Klahn P,Brönstrup M

更新日期：2016-01-01 00:00:00

abstract：:There is a trend toward viral-based hybrid systems to furnish viral nanoparticles with enhanced features, for function beyond a delivery vehicle. Such hybrids have included Nanogold for microwave release, quantum dots and fluorescent moieties, to provide simultaneous imaging capabilities, and iron oxide particles for ...

journal_title：Current topics in microbiology and immunology

authors： Portney NG,Destito G,Manchester M,Ozkan M

更新日期：2009-01-01 00:00:00

abstract：:The increased risk for severe dengue disease during secondary dengue virus (DENV) infections, along with the clinical and pathological evidence pointing to cytokines as the proximal mediators of disease, has interested cellular immunologists in exploring the role of DENV-specific T lymphocytes in the pathogenesis of d...

journal_title：Current topics in microbiology and immunology

authors： Rothman AL

更新日期：2010-01-01 00:00:00

abstract：:It has been estimated that there are more microorganisms within and upon the human body than there are human cells. By necessity, every accessible niche must be defended by innate mechanisms to prevent invasive infection, and ideally that precludes the need for robust inflammatory responses. Yet the potential for path...

journal_title：Current topics in microbiology and immunology

authors： Yeaman MR,Bayer AS

更新日期：2006-01-01 00:00:00

abstract：:Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the ...

journal_title：Current topics in microbiology and immunology

authors： Niedermann G

更新日期：2002-01-01 00:00:00

abstract：:Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in...

journal_title：Current topics in microbiology and immunology

authors： Corneth OBJ,Klein Wolterink RGJ,Hendriks RW

更新日期：2016-01-01 00:00:00

abstract：:During early stages of development, precursor B lymphocytes express a characteristic type of antigen receptor known as the pre-B-cell receptor (pre-BCR). This receptor differs from conventional BCRs in that it possesses a germ line-encoded surrogate light chain (SLC), which is associated with the signal transduction m...

journal_title：Current topics in microbiology and immunology

authors： Übelhart R,Werner M,Jumaa H

更新日期：2016-01-01 00:00:00

abstract：:The possibility that a new form of human prion disease, variant Creutzfeldt-Jakob disease (vCJD) had occurred in the UK was first raised by the identification of a small number of cases with unusual clinical characteristics. Atypical features included a young age at death, a predominantly psychiatric presentation, a r...

journal_title：Current topics in microbiology and immunology

authors： Will RG,Ward HJ

更新日期：2004-01-01 00:00:00