History of Swine influenza.

abstract：:Protein synthesis requires nutrients both as precursors (amino acids) and as a source of energy, since this process consumes a high proportion of cellular metabolic energy. Recent work has shown that both types of nutrients directly influence the activities of components of the translational machinery in mammalian cel...

journal_title：Current topics in microbiology and immunology

authors： Proud CG

更新日期：2004-01-01 00:00:00

abstract：:An account is given of the experiences and events which led to a search being undertaken for a causative virus in the recently described Burkitt's lymphoma and of the steps which ultimately culminated in the discovery of the new human herpesvirus which came to be known as Epstein-Barr virus (EBV). ...

journal_title：Current topics in microbiology and immunology

authors： Epstein A

更新日期：2015-01-01 00:00:00

abstract：:Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it ...

journal_title：Current topics in microbiology and immunology

authors： Blondel B,Colbère-Garapin F,Couderc T,Wirotius A,Guivel-Benhassine F

更新日期：2005-01-01 00:00:00

abstract：:Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...

journal_title：Current topics in microbiology and immunology

authors： Mori Y,Sadaoka T

更新日期：2010-01-01 00:00:00

abstract：:Influenza hemagglutinin (HA) is the major surface glycoprotein on influenza viruses and mediates viral attachment and subsequent fusion with host cells. The HA is the major target of the immune response, but due to its high level of variability, as evidenced by substantial antigenic diversity, it had been historically...

journal_title：Current topics in microbiology and immunology

authors： Lee PS,Wilson IA

更新日期：2015-01-01 00:00:00

abstract：:Certain vertebrates are capable of regenerating parts of the eye, including the lens. Depending on the species, two principal forms of in vivo lens regeneration have been described wherein the new lens arises from either the pigmented epithelium of the dorsal iris or the cornea epithelium. These forms of lens regenera...

journal_title：Current topics in microbiology and immunology

authors： Henry JJ,Thomas AG,Hamilton PW,Moore L,Perry KJ

更新日期：2013-01-01 00:00:00

abstract：:B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine sig...

journal_title：Current topics in microbiology and immunology

authors： Clark MR,Cooper AB,Wang LD,Aifantis I

更新日期：2005-01-01 00:00:00

abstract：:The global need for a pandemic influenza vaccine is large. High-income countries have stated their intent to provide universal access for pandemic influenza vaccine to their populations. Assuming that a two-dose schedule would be needed, providing universal coverage globally would represent approximately 6.5 billion t...

journal_title：Current topics in microbiology and immunology

authors： Edwards KM,Sabow A,Pasternak A,Boslego JW

更新日期：2009-01-01 00:00:00

abstract：:Poxviruses have been long regarded as potent inhibitors of apoptotic cell death. More recently, they have been shown to inhibit necroptotic cell death through two distinct strategies. These strategies involve either blocking virus sensing by the host pattern recognition receptor, ZBP1 (also called DAI) or by influenci...

journal_title：Current topics in microbiology and immunology

authors： Koehler HS,Jacobs BL

更新日期：2021-01-29 00:00:00

abstract：:The prototypes of the human MYC and RAF gene families are orthologs of animal proto-oncogenes that were originally identified as transduced alleles in the genomes of highly oncogenic retroviruses. MYC and RAF genes are now established as key regulatory elements in normal cellular physiology, but also as major cancer d...

journal_title：Current topics in microbiology and immunology

authors： Stefan E,Bister K

更新日期：2017-01-01 00:00:00

abstract：:Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its targe...

journal_title：Current topics in microbiology and immunology

authors： Hagman J,Ramírez J,Lukin K

更新日期：2012-01-01 00:00:00

abstract：:Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches...

journal_title：Current topics in microbiology and immunology

authors： Wagner N,Atsmon-Raz Y,Ashkenasy G

更新日期：2016-01-01 00:00:00

abstract：:Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...

journal_title：Current topics in microbiology and immunology

authors： Steinman L,Utz PJ,Robinson WH

更新日期：2005-01-01 00:00:00

abstract：:Clostridium difficile causes infectious diarrhoea in humans and animals. It has been found in both diarrhoeal and non-diarrhoeal pigs, horses and cattle, suggesting a potential reservoir for human insection, and in 20-40 % of meat products in Canada and the USA, suggesting the possibility, albeit not proven, of food-b...

journal_title：Current topics in microbiology and immunology

authors： Squire MM,Riley TV

更新日期：2013-01-01 00:00:00

abstract：:HAM/TSP is a chronic inflammatory disease of the spinal cord. It is rather rare in HTLV-1-infected individuals. Immunogenetic factors of the HLA complex have been identified that support or prevent the development of the disease. In HAM/TSP patients a characteristic constellation of high proviral loads and increased c...

journal_title：Current topics in microbiology and immunology

authors： Kitze B,Usuku K

更新日期：2002-01-01 00:00:00

abstract：:The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...

journal_title：Current topics in microbiology and immunology

authors： Offringa R,de Jong A,Toes RE,van der Burg SH,Melief CJ

更新日期：2003-01-01 00:00:00

abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...

journal_title：Current topics in microbiology and immunology

authors： Gosztonyi G,Ludwig H

更新日期：1995-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00

abstract：:The field of autophagy research has advanced rapidly in recent years, with important discoveries made in relation to both molecular mechanisms and physiological functions. Initially, autophagy was thought to be primarily a response to starvation. Although this might be true in lower eukaryotes, this catabolic process ...

journal_title：Current topics in microbiology and immunology

authors： Mizushima N

更新日期：2009-01-01 00:00:00

abstract：:Axonal transport ensures long-range delivery of essential components and signals between proximal and distal areas of the neuron, and it is crucial for neuronal homeostasis and survival. Several pathogens and virulence factors use this route to gain access to the central nervous system, exploiting the complex and stil...

journal_title：Current topics in microbiology and immunology

authors： Bercsenyi K,Giribaldi F,Schiavo G

更新日期：2013-01-01 00:00:00

abstract：:Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the ...

journal_title：Current topics in microbiology and immunology

authors： Niedermann G

更新日期：2002-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of ...

journal_title：Current topics in microbiology and immunology

authors： Pickles RJ

更新日期：2013-01-01 00:00:00

abstract：:Japanese encephalitis (JE) is one of the most well studied arthropod zoonotic diseases with human and animal research and their integration spanning 6-7 decades. JE research and policy in some Asian countries has epitomized the 'One Health' strategy of attainment of optimal health for people, animals, and the environm...

journal_title：Current topics in microbiology and immunology

authors： Impoinvil DE,Baylis M,Solomon T

更新日期：2013-01-01 00:00:00

abstract：:Phosphoinositide 3-kinases (PI 3-kinases) are activated by growth factor and hormone receptors, and regulate cell growth, survival, motility, and responses to changes in nutritional conditions (Engelman et al. 2006). PI 3-kinases have been classified according to their subunit composition and their substrate specifici...

journal_title：Current topics in microbiology and immunology

authors： Backer JM

更新日期：2010-01-01 00:00:00

abstract：:The low-resource environment deprives healthcare providers caring for patients with Ebola virus disease (EVD) of many of the means employed for the critically ill that are available in better resourced settings, such as advanced therapeutic interventions and abundant staff. In addition to these limitations may be adde...

journal_title：Current topics in microbiology and immunology

authors： Sprecher A,Van Herp M,Rollin PE

更新日期：2017-01-01 00:00:00

abstract：:The self-cleaving RNA sequences, or ribozymes, in the genomic and antigenomic strands of hepatitis delta virus (HDV) RNA fold into structures that are similar to each other but distinct from those of small ribozymes associated with the RNA replicons that infect plants. HDV ribozymes have provided a tractable system fo...

journal_title：Current topics in microbiology and immunology

authors： Been MD

更新日期：2006-01-01 00:00:00

abstract：:The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...

journal_title：Current topics in microbiology and immunology

authors： Tracy S,Chapman NM,Drescher KM,Kono K,Tapprich W

更新日期：2006-01-01 00:00:00

abstract：:Collective knowledge regarding the occurrence of influenza among swine is incomplete due to inconsistent surveillance of swine populations. In this chapter, we review what surveillance activities exist and some of the practical challenges encountered. Furthermore, to support robust surveillance activities, accurate la...

journal_title：Current topics in microbiology and immunology

authors： Detmer S,Gramer M,Goyal S,Torremorell M,Torrison J

更新日期：2013-01-01 00:00:00

abstract：:The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the ...

journal_title：Current topics in microbiology and immunology

authors： Dash P,Thomas PG

更新日期：2015-01-01 00:00:00

abstract：:Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization. Several key fact...

journal_title：Current topics in microbiology and immunology

authors： Beloin C,Roux A,Ghigo JM

更新日期：2008-01-01 00:00:00