Poliovirus, pathogenesis of poliomyelitis, and apoptosis.

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:The surface membrane molecule CD5 is expressed on mature T cells and on the B-1a subpopulation of B cells. These CD5 positive B cells express an antibody repertoire with a relatively high frequency of self-reactivity. There is uncertainty about the origins of CD5 B cells and the reasons for this are reviewed. Recent r...

journal_title：Current topics in microbiology and immunology

authors： Bandyopadhyay RS,Teutsch MR,Wortis HH

更新日期：1995-01-01 00:00:00

abstract：:The ubiquitous, opportunistic pathogen human cytomegalovirus (CMV) encodes several proteins homologous to those of the host organism. Four different CMV genes encode chemokine receptor-like peptides. These genes, UL33, UL78, US27, and US28, are expressed at various stages of infection in vitro. Their functions remain ...

journal_title：Current topics in microbiology and immunology

authors： Beisser PS,Goh CS,Cohen FE,Michelson S

更新日期：2002-01-01 00:00:00

abstract：:The fibroblast growth factor (FGF) family contains 23 members in mammals including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation of many key cellular responses involved in developmental and physiological processes. These includes proliferation, differentiation, migration, apoptosis, an...

journal_title：Current topics in microbiology and immunology

authors： Wiedłocha A,Sørensen V

更新日期：2004-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00

abstract：:The activation and expansion of T cells in an antimicrobial immune response is based on the ability of T cell receptors (TCR) to discriminate between MHC-bound peptides derived from different microbial agents as well as self-proteins. However, the specificity of T cells is constrained by the limited number of peptide ...

journal_title：Current topics in microbiology and immunology

authors： Wucherpfennig KW

更新日期：2005-01-01 00:00:00

abstract：:Genetic variation of the host significantly contributes to dramatic differences in the outcomes of natural infection with virulent Mycobacterium tuberculosis (MTB) in humans, as well as in experimental animal models. Host resistance to tuberculosis is a complex multifactorial genetic trait in which many genetic polymo...

journal_title：Current topics in microbiology and immunology

authors： Kramnik I

更新日期：2008-01-01 00:00:00

abstract：:Yersinia entercolitica and Yersinia pseudotuberculosis are human foodborne pathogens that interact extensively with tissues of the gut and the host's immune system to cause disease. As part of their pathogenic strategies, the Yersinia have evolved numerous ways to invade host tissues, gain essential nutrients, and eva...

journal_title：Current topics in microbiology and immunology

authors： Dube P

更新日期：2009-01-01 00:00:00

abstract：:Ischemic cardiomyopathy leading to congestive heart failure remains the leading source of morbidity and mortality in Western society and medical management of this condition offers only palliative treatment. While allogeneic heart transplantation can both extend and improve the quality of life for patients with end-st...

journal_title：Current topics in microbiology and immunology

authors： Krupnick AS,Kreisel D,Riha M,Balsara KR,Rosengard BR

更新日期：2004-01-01 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...

journal_title：Current topics in microbiology and immunology

authors： Chandrahas VK,Han J,Kaufman RJ

更新日期：2018-01-01 00:00:00

abstract：:This chapter highlights the cholera situation in South Asia and the Bay of Bengal region, the original 'homeland' of cholera. A detailed discussion of cholera outbreaks in individual countries in South-East Asia follows. The countries of the World Health Organization (WHO) SEARO (South-East Asia Region) region are dis...

journal_title：Current topics in microbiology and immunology

authors： Bharati K,Bhattacharya SK

更新日期：2014-01-01 00:00:00

abstract：:Legionella is a gram-negative bacterium and the causative pathogen of legionellosis-a severe pneumonia in humans. A large number of Legionella effectors interfere with numerous host cell functions, including intracellular vacuole trafficking and maturation, phospholipid metabolism, protein ubiquitination, pro-/anti-ap...

journal_title：Current topics in microbiology and immunology

authors： Belyi Y,Jank T,Aktories K

更新日期：2013-01-01 00:00:00

abstract：:Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assemb...

journal_title：Current topics in microbiology and immunology

authors： Jaskiewicz L,Filipowicz W

更新日期：2008-01-01 00:00:00

abstract：:Our understanding of the mechanisms involved in the formation of the complex arrangement of neurons and their interconnections within the brain has made significant progress in recent years. Current research has uncovered a network of intracellular signaling events that provide precise coordination of a diverse array ...

journal_title：Current topics in microbiology and immunology

authors： Waite K,Eickholt BJ

更新日期：2010-01-01 00:00:00

abstract：:Negative-strand RNA virus particles are formed by a process that includes the assembly of viral components at the plasma membranes of infected cells and the subsequent release of particles by budding. Here, we review recent progress that has been made in understanding the mechanisms of negative-strand RNA virus assemb...

journal_title：Current topics in microbiology and immunology

authors： Schmitt AP,Lamb RA

更新日期：2004-01-01 00:00:00

abstract：:Influenza vaccines are the mainstay of efforts to reduce the substantial health burden from seasonal influenza. Inactivated influenza vaccines have been available since the 1940s and are administered via intramuscular injection. Inactivated vaccines can be given to anyone six months of age or older. Live attenuated, c...

journal_title：Current topics in microbiology and immunology

authors： Fiore AE,Bridges CB,Cox NJ

更新日期：2009-01-01 00:00:00

abstract：:Rhabdoviruses, mainly in rainbow trout, are among the most devastating viruses for worldwide aquaculture. To date no effective treatments to fight against these viruses are available. During the past years, several approaches to develop efficient vaccines have been undertaken such as the use of immunogenic recombinant...

journal_title：Current topics in microbiology and immunology

authors： Brémont M

更新日期：2005-01-01 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00

abstract：:The collaboration between Alick Isaacs and myself started in the summer of 1956. Our initial project was to show, by electron microscopy, that interference between inactivated influenza virus and live virus involved the transfer of material from the interfering virus to the host cell. This approach failed for technica...

journal_title：Current topics in microbiology and immunology

authors： Lindenmann J

更新日期：2007-01-01 00:00:00

abstract：:The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely thos...

journal_title：Current topics in microbiology and immunology

authors： Pirity M,Blanck JK,Schreiber-Agus N

更新日期：2006-01-01 00:00:00

abstract：:Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...

journal_title：Current topics in microbiology and immunology

authors： Baldwin MR,Barbieri JT

更新日期：2005-01-01 00:00:00

abstract：:The family of protein tyrosine phosphatases (PTPs) includes 107 genes in humans that are diverse in their structures and expression profiles. The majority are present in immune cells and play various roles in either inhibiting or promoting the duration and amplitude of signaling cascades. Several PTPs, including TC-PT...

journal_title：Current topics in microbiology and immunology

authors： Penafuerte C,Perez-Quintero LA,Vinette V,Hatzihristidis T,Tremblay ML

更新日期：2017-01-01 00:00:00

abstract：:The possible role of silicone in the pathogenesis of a scleroderma-like syndrome is still unresolved. It has been proposed that silicone escaping from breast implants potentiates the progression of the disease. To clarify whether silicone enhances development of fibrotic skin lesions and autoantibodies, we tested its ...

journal_title：Current topics in microbiology and immunology

authors： Frondoza C,Jones L,Rose NR,Hatakeyama A,Phelps R,Bona C

更新日期：1996-01-01 00:00:00

abstract：:The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its ta...

journal_title：Current topics in microbiology and immunology

authors： McCormick R,Buffa FM,Ragoussis J,Harris AL

更新日期：2010-01-01 00:00:00

abstract：:A number of Gram-positive bacteria are important players in industry as producers of a diverse array of economically interesting metabolites and proteins. As discussed in this overview, several Gram-positive bacteria are valuable hosts for the production of heterologous proteins. In contrast to Gram-negative bacteria,...

journal_title：Current topics in microbiology and immunology

authors： Anné J,Economou A,Bernaerts K

更新日期：2017-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world's population. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent grow...

journal_title：Current topics in microbiology and immunology

authors： Hislop AD,Taylor GS

更新日期：2015-01-01 00:00:00

abstract：:Measles ranks fifth among the five major childhood conditions which are responsible for 21% of all deaths in low and middle-income countries. Measles immunization is considered the most cost-effective public health intervention in the world. In recent years, there has been a critical need to identify alternative route...

journal_title：Current topics in microbiology and immunology

authors： Valdespino-Gómez JL,de Lourdes Garcia-Garcia M,Fernandez-de-Castro J,Henao-Restrepo AM,Bennett J,Sepulveda-Amor J

更新日期：2006-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of ...

journal_title：Current topics in microbiology and immunology

authors： Pickles RJ

更新日期：2013-01-01 00:00:00

abstract：:The application of fundamental concepts about the packaging of the adenovirus genome has contributed significantly to the development of therapeutic viral vectors for gene therapy. The packaging of adenovirus DNA into virus particles requires a cis-acting domain at the left end of the genome. This region contains a se...

journal_title：Current topics in microbiology and immunology

authors： Ostapchuk P,Hearing P

更新日期：2003-01-01 00:00:00