Host detection and the stealthy phenotype in influenza virus infection.

abstract：:Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....

journal_title：Current topics in microbiology and immunology

authors： Ota T,Sitnikova T,Nei M

更新日期：2000-01-01 00:00:00

abstract：:Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that mol...

journal_title：Current topics in microbiology and immunology

authors： Frolov I,Frolova EI

更新日期：2019-01-01 00:00:00

abstract：:Microbial biofilms are governed by an intricate interplay between physical-chemical factors and the physiological and genetic properties of the inhabiting microbes. Many of the physiological traits that are exhibited in a biofilm environment have been observed and studied previously in detail in planktonic cultures. H...

journal_title：Current topics in microbiology and immunology

authors： Spormann AM

更新日期：2008-01-01 00:00:00

abstract：:The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...

journal_title：Current topics in microbiology and immunology

authors： Tracy S,Chapman NM,Drescher KM,Kono K,Tapprich W

更新日期：2006-01-01 00:00:00

abstract：:In conventionally reared mice germinal centers (GCs) are chronically induced in Peyer's patches (PP), mesenteric lymph node (MLN), and isolated lymphoid follicles (ILF) of gut-associated lymphoid tissues (GALT), as a result of continuous B cell stimulation by commensal bacteria. It is generally thought that BCR-mediat...

journal_title：Current topics in microbiology and immunology

authors： Casola S,Rajewsky K

更新日期：2006-01-01 00:00:00

abstract：:In summary, the complement system has evolved an important function in regulation of humoral immunity to T-dependent antigens. Covalent attachment of activated C3 to antigen alters its fate by enhancing uptake on the surface of FDC via CD21/CD35; and by enhancing signal transduction via the B cell coreceptor CD21/CD19...

journal_title：Current topics in microbiology and immunology

authors： Carroll M

更新日期：1999-01-01 00:00:00

abstract：:Selected microenvironmental stimuli confer to leukemic cells a growth advantage and an extended survival. We aimed at dissecting the differential support provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence...

journal_title：Current topics in microbiology and immunology

authors： Ghia P,Circosta P,Scielzo C,Vallario A,Camporeale A,Granziero L,Caligaris-Cappio F

更新日期：2005-01-01 00:00:00

abstract：:The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its ta...

journal_title：Current topics in microbiology and immunology

authors： McCormick R,Buffa FM,Ragoussis J,Harris AL

更新日期：2010-01-01 00:00:00

abstract：:Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...

journal_title：Current topics in microbiology and immunology

authors： Baldwin MR,Barbieri JT

更新日期：2005-01-01 00:00:00

abstract：:Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. I...

journal_title：Current topics in microbiology and immunology

authors： Kubagawa H,Skopnik CM,Zimmermann J,Durek P,Chang HD,Yoo E,Bertoli LF,Honjo K,Radbruch A

更新日期：2017-01-01 00:00:00

abstract：:The hemagglutinin (HA) is a prime determinant of the pathogenicity of influenza A viruses. It initiates infection by binding to cell surface receptors and by inducing membrane fusion. The fusion capacity of HA depends on cleavage activation by host proteases, and it has long been known that highly pathogenic avian inf...

journal_title：Current topics in microbiology and immunology

authors： Böttcher-Friebertshäuser E,Garten W,Matrosovich M,Klenk HD

更新日期：2014-01-01 00:00:00

abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...

journal_title：Current topics in microbiology and immunology

authors： Gosztonyi G,Ludwig H

更新日期：1995-01-01 00:00:00

abstract：:Chloroplast genetic engineering offers several advantages, including high levels of transgene expression, transgene containment via maternal inheritance, and multi-gene expression in a single transformation event. Oral delivery is facilitated by hyperexpression of vaccine antigens against cholera, tetanus, anthrax, pl...

journal_title：Current topics in microbiology and immunology

authors： Chebolu S,Daniell H

更新日期：2009-01-01 00:00:00

abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...

journal_title：Current topics in microbiology and immunology

authors： Moss WJ

更新日期：2009-01-01 00:00:00

abstract：:Autoimmune gastritis (AIG) is an experimental model that closely resembles human autoimmune gastritis, the underlying pathology of pernicious anemia. Pathogenic CD4+ T cells are reactive to the parietal cell autoantigen, H/K ATPase, and are controlled by CD4+CD25+ T cells in an immunosuppressive cytokine-independent m...

journal_title：Current topics in microbiology and immunology

authors： McHugh RS

更新日期：2005-01-01 00:00:00

abstract：:During early stages of development, precursor B lymphocytes express a characteristic type of antigen receptor known as the pre-B-cell receptor (pre-BCR). This receptor differs from conventional BCRs in that it possesses a germ line-encoded surrogate light chain (SLC), which is associated with the signal transduction m...

journal_title：Current topics in microbiology and immunology

authors： Übelhart R,Werner M,Jumaa H

更新日期：2016-01-01 00:00:00

abstract：:Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specif...

journal_title：Current topics in microbiology and immunology

authors： Kumar R,Amado RG

更新日期：2012-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...

journal_title：Current topics in microbiology and immunology

authors： Chandrahas VK,Han J,Kaufman RJ

更新日期：2018-01-01 00:00:00

abstract：:Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is hig...

journal_title：Current topics in microbiology and immunology

authors： Habenstein B,El Mammeri N,Tolchard J,Lamon G,Tawani A,Berbon M,Loquet A

更新日期：2020-01-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell,...

journal_title：Current topics in microbiology and immunology

authors： Skoberne M,Beignon AS,Larsson M,Bhardwaj N

更新日期：2005-01-01 00:00:00

abstract：:Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assemb...

journal_title：Current topics in microbiology and immunology

authors： Jaskiewicz L,Filipowicz W

更新日期：2008-01-01 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:Most eukaryotic messenger RNAs are transcribed as precursors that necessitate specific and exact processing of intron boundaries. Furthermore, the choice of these boundaries appears to be fluid and adaptive to the rate of transcription and the developmental and physiological state of the cell. A central regulator of s...

journal_title：Current topics in microbiology and immunology

authors： Fluhr R

更新日期：2008-01-01 00:00:00

abstract：:IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 levels and a strong infiltration of IgG4-positive plasma cells in various organs. IgG4-RD patients also frequently suffer from allergic diseases, including asthma and atopic dermatitis. It is well known that T helper type 2 (Th2)...

journal_title：Current topics in microbiology and immunology

authors： Moriyama M,Nakamura S

更新日期：2017-01-01 00:00:00

abstract：:Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model. Multiple mechanisms of activation of c-myb by retroviral insertional mutagenesis implicate both transcriptional deregulation...

journal_title：Current topics in microbiology and immunology

authors： Wolff L,Koller R,Bies J,Nazarov V,Hoffman B,Amanullah A,Krall M,Mock B

更新日期：1996-01-01 00:00:00

abstract：:Bacterial polysaccharides play an essential role in cell viability, virulence, and evasion of host defenses. Although the polysaccharides themselves are highly diverse, the pathways by which bacteria synthesize these essential polymers are conserved in both Gram-negative and Gram-positive organisms. By utilizing a lip...

journal_title：Current topics in microbiology and immunology

authors： Taylor VL,Huszczynski SM,Lam JS

更新日期：2017-01-01 00:00:00

abstract：:Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization. Several key fact...

journal_title：Current topics in microbiology and immunology

authors： Beloin C,Roux A,Ghigo JM

更新日期：2008-01-01 00:00:00

abstract：:The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the ami...

journal_title：Current topics in microbiology and immunology

authors： Amoasii L,Hnia K,Laporte J

更新日期：2012-01-01 00:00:00

abstract：:A number of Gram-positive bacteria are important players in industry as producers of a diverse array of economically interesting metabolites and proteins. As discussed in this overview, several Gram-positive bacteria are valuable hosts for the production of heterologous proteins. In contrast to Gram-negative bacteria,...

journal_title：Current topics in microbiology and immunology

authors： Anné J,Economou A,Bernaerts K

更新日期：2017-01-01 00:00:00

abstract：:Recombinant protein- and peptide-based vaccines can deliver large amounts of specific antigens for tailored immune responses. One class of these are protein and peptide nanoclusters (PNCs), which are made entirely from the crosslinked antigen. PNCs leverage the inherent immunogenicity of nanoparticulate antigens while...

journal_title：Current topics in microbiology and immunology

authors： Chang TZ,Champion JA

更新日期：2020-11-10 00:00:00