Abstract：
:Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model. Multiple mechanisms of activation of c-myb by retroviral insertional mutagenesis implicate both transcriptional deregulation and protein truncation in conversion of this proto-oncogene to an oncogene. Because transformation by c-Myb can be viewed as a block to differentiation our studies moved into two in vitro systems to evaluate effects of truncated forms of c-Myb on cytokine induced maturation of myeloid progenitors to the granulocyte and macrophage lineages. Deregulated expression of truncated and full length c-Myb did not result in maintenance of the myelomonocytic progenitor state but rather a block in differentiation at intermediate to late steps in the maturation processes of myelomonocytic cells. Our results argue that inhibition of differentiation is due to c-Myb's ability to maintain the proliferative state of cells. Interestingly, the phenotype of continuously proliferating monocytic cells resembles that of the tumor cell phenotype. Recently we identified a new target of integration, Mml1, which is rearranged in ten promonocytic leukemias that do not have c-myb rearrangements. This locus which was mapped to chromosome 10 is presently being characterized.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Wolff L,Koller R,Bies J,Nazarov V,Hoffman B,Amanullah A,Krall M,Mock Bdoi
10.1007/978-3-642-85232-9_19subject
Has Abstractpub_date
1996-01-01 00:00:00pages
191-9eissn
0070-217Xissn
2196-9965journal_volume
211pub_type
杂志文章,评审abstract：:Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2015_478
更新日期：2016-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-01846-6_3
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-72146-8_3
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
doi：10.1007/978-3-642-77633-5_62
更新日期：1992-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
doi：10.1007/978-3-642-79275-5_33
更新日期：1995-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-55541-1_2
更新日期：2003-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2013_348
更新日期：2013-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/3-540-27511-8_5
更新日期：2005-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：1995-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-60162-0_28
更新日期：1999-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/3-540-31181-5_8
更新日期：2006-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 历史文章,杂志文章,评审
doi：10.1007/978-3-540-71329-6_1
更新日期：2007-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
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更新日期：2018-09-20 00:00:00
abstract：:Selected microenvironmental stimuli confer to leukemic cells a growth advantage and an extended survival. We aimed at dissecting the differential support provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/3-540-29933-5_8
更新日期：2005-01-01 00:00:00
