Interaction of Yersinia with the gut: mechanisms of pathogenesis and immune evasion.

abstract：:During early stages of development, precursor B lymphocytes express a characteristic type of antigen receptor known as the pre-B-cell receptor (pre-BCR). This receptor differs from conventional BCRs in that it possesses a germ line-encoded surrogate light chain (SLC), which is associated with the signal transduction m...

journal_title：Current topics in microbiology and immunology

authors： Übelhart R,Werner M,Jumaa H

更新日期：2016-01-01 00:00:00

abstract：:Certain vertebrates are capable of regenerating parts of the eye, including the lens. Depending on the species, two principal forms of in vivo lens regeneration have been described wherein the new lens arises from either the pigmented epithelium of the dorsal iris or the cornea epithelium. These forms of lens regenera...

journal_title：Current topics in microbiology and immunology

authors： Henry JJ,Thomas AG,Hamilton PW,Moore L,Perry KJ

更新日期：2013-01-01 00:00:00

abstract：:Selected microenvironmental stimuli confer to leukemic cells a growth advantage and an extended survival. We aimed at dissecting the differential support provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence...

journal_title：Current topics in microbiology and immunology

authors： Ghia P,Circosta P,Scielzo C,Vallario A,Camporeale A,Granziero L,Caligaris-Cappio F

更新日期：2005-01-01 00:00:00

abstract：:NF-κB is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. The activity of NF-κB is tightly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase, which phosphorylates...

journal_title：Current topics in microbiology and immunology

authors： Sun SC,Cesarman E

更新日期：2011-01-01 00:00:00

abstract：:The Gram-negative bacterium Helicobacter pylori is predominantly known for its tight association with peptic ulcer disease and gastric cancer development. However, recent epidemiological and experimental evidence suggests that chronic infection with H. pylori may at the same time be beneficial to the host by conferrin...

journal_title：Current topics in microbiology and immunology

authors： Kyburz A,Müller A

更新日期：2017-01-01 00:00:00

abstract：:B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine sig...

journal_title：Current topics in microbiology and immunology

authors： Clark MR,Cooper AB,Wang LD,Aifantis I

更新日期：2005-01-01 00:00:00

abstract：:Recent advances in inductively coupled plasma mass spectrometry (ICP-MS) as applied in mass cytometry, enabled its broad applicability to life science research. Mass cytometry enables the high-dimensional characterization of cellular systems by simultaneously measuring dozens of metal isotope reporter labeled antibodi...

journal_title：Current topics in microbiology and immunology

authors： Zivanovic N,Jacobs A,Bodenmiller B

更新日期：2014-01-01 00:00:00

abstract：:Primary varicella-zoster virus (VZV) infection (varicella) induces VZV-specific antibody and VZV-specific T cell-mediated immunity. T cell-mediated immunity, which is detected within 1-2 weeks after appearance of rash, and consists of both CD4 and CD8 effector and memory T cells, is essential for recovery from varicel...

journal_title：Current topics in microbiology and immunology

authors： Weinberg A,Levin MJ

更新日期：2010-01-01 00:00:00

abstract：:The "humanized mouse" is a mouse harboring functioning human tissues used as in vivo human models for both physiological and pathological conditions. The NOD/Shi-scid IL2rgamma(null) (NOG) mouse, an excellent immunodeficient mouse used as the basis for the humanized mouse, requires strict genetic and environmental con...

journal_title：Current topics in microbiology and immunology

authors： Nomura T,Tamaoki N,Takakura A,Suemizu H

更新日期：2008-01-01 00:00:00

abstract：:DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the ho...

journal_title：Current topics in microbiology and immunology

authors： Zawilak-Pawlik A,Zakrzewska-Czerwińska J

更新日期：2017-01-01 00:00:00

abstract：:Natural killer (NK) cells are crucial to mounting an effective immune response. They have a significant role in cancer immunosurveillance and function as a bridge between innate and adaptive immunity. However, until recently, surprisingly little was known about the molecular basis of NK cell development as compared to...

journal_title：Current topics in microbiology and immunology

authors： Male V,Brady HJ

更新日期：2014-01-01 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively...

journal_title：Current topics in microbiology and immunology

authors： Hayes JM,Cosgrave EF,Struwe WB,Wormald M,Davey GP,Jefferis R,Rudd PM

更新日期：2014-01-01 00:00:00

abstract：:Enzootic nasal adenocarcinoma is a contagious tumour of the mucosal nasal glands affecting young adult sheep or goats. The disease occurs naturally in all continents except Australia and New Zealand. Clinical signs include continuous nasal discharge, respiratory distress, exophthalmos and skull deformations. The tumou...

journal_title：Current topics in microbiology and immunology

authors： De las Heras M,Ortín A,Cousens C,Minguijón E,Sharp JM

更新日期：2003-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important human respiratory pathogen with narrow species tropism. Limited availability of human pathologic specimens during early RSV-induced lung disease and ethical restrictions for RSV challenge studies in the lower airways of human volunteers has slowed our understanding of ...

journal_title：Current topics in microbiology and immunology

authors： Pickles RJ

更新日期：2013-01-01 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen, responsible for infections in the community and the healthcare setting. Although much of the attention is focused on the methicillin-resistant "variant" MRSA, the methicillin-susceptible counterpart (MSSA) remains a prime species in infections. The epidemiology of ...

journal_title：Current topics in microbiology and immunology

authors： Monaco M,Pimentel de Araujo F,Cruciani M,Coccia EM,Pantosti A

更新日期：2017-01-01 00:00:00

abstract：:The global need for a pandemic influenza vaccine is large. High-income countries have stated their intent to provide universal access for pandemic influenza vaccine to their populations. Assuming that a two-dose schedule would be needed, providing universal coverage globally would represent approximately 6.5 billion t...

journal_title：Current topics in microbiology and immunology

authors： Edwards KM,Sabow A,Pasternak A,Boslego JW

更新日期：2009-01-01 00:00:00

abstract：:The capacity of varicella zoster virus (VZV) to cause varicella (chickenpox) relies upon multiple steps, beginning with inoculation of the host at mucosal sites with infectious virus in respiratory droplets. Despite the presence of a powerful immune defense system, this virus is able to disseminate from the site of in...

journal_title：Current topics in microbiology and immunology

authors： Abendroth A,Kinchington PR,Slobedman B

更新日期：2010-01-01 00:00:00

abstract：:Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermo...

journal_title：Current topics in microbiology and immunology

authors： Horiguchi Y

更新日期：2012-01-01 00:00:00

abstract：:The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...

journal_title：Current topics in microbiology and immunology

authors： Offringa R,de Jong A,Toes RE,van der Burg SH,Melief CJ

更新日期：2003-01-01 00:00:00

abstract：:Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit se...

journal_title：Current topics in microbiology and immunology

authors： Mittal J,Ponce MG,Gendlina I,Nosanchuk JD

更新日期：2019-01-01 00:00:00

abstract：:Genetic variation of the host significantly contributes to dramatic differences in the outcomes of natural infection with virulent Mycobacterium tuberculosis (MTB) in humans, as well as in experimental animal models. Host resistance to tuberculosis is a complex multifactorial genetic trait in which many genetic polymo...

journal_title：Current topics in microbiology and immunology

authors： Kramnik I

更新日期：2008-01-01 00:00:00

abstract：:Rabies, being a major zoonotic disease, significantly impacts global public health. It is invariably fatal once clinical signs are apparent. The majority of human rabies deaths occur in developing countries. India alone reports more than 50% of the global rabies deaths. Although it is a vaccine-preventable disease, ef...

journal_title：Current topics in microbiology and immunology

authors： Nagarajan T,Rupprecht CE,Dessain SK,Rangarajan PN,Thiagarajan D,Srinivasan VA

更新日期：2008-01-01 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00

abstract：:T cell activation begins with the interaction between an antigen-specific T cell and an antigen-presenting cell (APC). This interaction results in the formation of the immunological synapse, which had been considered to be responsible for antigen recognition and T cell activation. Recent advances in imaging analysis h...

journal_title：Current topics in microbiology and immunology

authors： Yokosuka T,Saito T

更新日期：2010-01-01 00:00:00

abstract：:A number of Gram-positive bacteria are important players in industry as producers of a diverse array of economically interesting metabolites and proteins. As discussed in this overview, several Gram-positive bacteria are valuable hosts for the production of heterologous proteins. In contrast to Gram-negative bacteria,...

journal_title：Current topics in microbiology and immunology

authors： Anné J,Economou A,Bernaerts K

更新日期：2017-01-01 00:00:00

abstract：:An evolution in modern malaria research occurred with the completion of the Plasmodium falciparum genome project and the onset and application of novel post-genomic technologies. Corresponding with these technological achievements are improvements in accessing and purifying parasite material from 'hard-to-reach' stage...

journal_title：Current topics in microbiology and immunology

authors： Blair PL,Carucci DJ

更新日期：2005-01-01 00:00:00

abstract：:The hemagglutinin (HA) is a prime determinant of the pathogenicity of influenza A viruses. It initiates infection by binding to cell surface receptors and by inducing membrane fusion. The fusion capacity of HA depends on cleavage activation by host proteases, and it has long been known that highly pathogenic avian inf...

journal_title：Current topics in microbiology and immunology

authors： Böttcher-Friebertshäuser E,Garten W,Matrosovich M,Klenk HD

更新日期：2014-01-01 00:00:00

abstract：:The application of fundamental concepts about the packaging of the adenovirus genome has contributed significantly to the development of therapeutic viral vectors for gene therapy. The packaging of adenovirus DNA into virus particles requires a cis-acting domain at the left end of the genome. This region contains a se...

journal_title：Current topics in microbiology and immunology

authors： Ostapchuk P,Hearing P

更新日期：2003-01-01 00:00:00

abstract：:It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes ...

journal_title：Current topics in microbiology and immunology

authors： Johannesson M,Hultqvist M,Holmdahl R

更新日期：2006-01-01 00:00:00