Abstract:
:An evolution in modern malaria research occurred with the completion of the Plasmodium falciparum genome project and the onset and application of novel post-genomic technologies. Corresponding with these technological achievements are improvements in accessing and purifying parasite material from 'hard-to-reach' stages of malaria development. Characterization of gene and protein expression in the infectious sporozoite and subsequent liver-stage parasite development is critical to identify novel pre-erythrocytic drug and vaccine targets as well as to understand the basic biology of this deadly parasite. Both transcriptional and proteomic analyses on these stages and the remaining stages of development will assist in the 'credentialing process' of the complete malaria genome.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Blair PL,Carucci DJdoi
10.1007/3-540-29088-5_16subject
Has Abstractpub_date
2005-01-01 00:00:00pages
417-38eissn
0070-217Xissn
2196-9965journal_volume
295pub_type
杂志文章,评审abstract::Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches...
journal_title:Current topics in microbiology and immunology
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abstract::Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...
journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
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abstract::Influenza vaccines are the mainstay of efforts to reduce the substantial health burden from seasonal influenza. Inactivated influenza vaccines have been available since the 1940s and are administered via intramuscular injection. Inactivated vaccines can be given to anyone six months of age or older. Live attenuated, c...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-59674-2_10
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abstract::In normal cells, the proto-oncogene c-myc is regulated by promoter-proximal pausing of RNA polymerase II (pol II). In Burkitt lymphoma cells, c-myc is chromosomally translocated to one of the three immunoglobulin (Ig) gene loci and its transcription is driven constitutively by Ig enhancers. Promoter-proximal pausing o...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-60162-0_28
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abstract::Rabies, being a major zoonotic disease, significantly impacts global public health. It is invariably fatal once clinical signs are apparent. The majority of human rabies deaths occur in developing countries. India alone reports more than 50% of the global rabies deaths. Although it is a vaccine-preventable disease, ef...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-07911-0_8
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-79663-0_2
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abstract::Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/978-3-642-72153-3_2
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abstract::This review will focus on the principal clinical and pathophysiological features of the anaemia of falciparum malaria, including the problems of treating malarial anaemia, and also will suggest how recent advances in genomics may help our understanding of cellular and molecular mechanisms underlying this syndrome. ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-29088-5_6
更新日期:2005-01-01 00:00:00
abstract::The possible role of silicone in the pathogenesis of a scleroderma-like syndrome is still unresolved. It has been proposed that silicone escaping from breast implants potentiates the progression of the disease. To clarify whether silicone enhances development of fibrotic skin lesions and autoantibodies, we tested its ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/978-3-642-85226-8_31
更新日期:1996-01-01 00:00:00
abstract::The activation and expansion of T cells in an antimicrobial immune response is based on the ability of T cell receptors (TCR) to discriminate between MHC-bound peptides derived from different microbial agents as well as self-proteins. However, the specificity of T cells is constrained by the limited number of peptide ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-30791-5_2
更新日期:2005-01-01 00:00:00
abstract::The possibility that a new form of human prion disease, variant Creutzfeldt-Jakob disease (vCJD) had occurred in the UK was first raised by the identification of a small number of cases with unusual clinical characteristics. Atypical features included a young age at death, a predominantly psychiatric presentation, a r...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-08441-0_5
更新日期:2004-01-01 00:00:00
abstract::Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that mol...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/82_2018_146
更新日期:2019-01-01 00:00:00
abstract::Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization. Several key fact...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-75418-3_12
更新日期:2008-01-01 00:00:00
abstract::Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermo...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_206
更新日期:2012-01-01 00:00:00
abstract::Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Clostridium difficile causes infectious diarrhoea in humans and animals. It has been found in both diarrhoeal and non-diarrhoeal pigs, horses and cattle, suggesting a potential reservoir for human insection, and in 20-40 % of meat products in Canada and the USA, suggesting the possibility, albeit not proven, of food-b...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::The ubiquitous, opportunistic pathogen human cytomegalovirus (CMV) encodes several proteins homologous to those of the host organism. Four different CMV genes encode chemokine receptor-like peptides. These genes, UL33, UL78, US27, and US28, are expressed at various stages of infection in vitro. Their functions remain ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
abstract::The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth muscle cells are the predominant targets for virus ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-77349-8_4
更新日期:2008-01-01 00:00:00
abstract::The varicella-zoster virus (VZV) open reading frame (ORF) 66 encodes a basophilic kinase orthologous to the US3 protein kinases found in all alphaherpesviruses. This review summarizes current information on the ORF66 kinase, and outlines apparent differences from other US3 kinases, as well as some of the conserved fun...
journal_title:Current topics in microbiology and immunology
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更新日期:2010-01-01 00:00:00
abstract::B cell development is a process tightly regulated by the orchestrated signaling of cytokine receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with common lymphoid progenitors (CLP) up-regulating the expression of B cell-related genes and committing to the B cell lineage. Cytokine sig...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-26363-2_5
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abstract::Translocations or amplifications which activate members of the myc gene family are common in human cancer. c-Myc is a central regulator of normal cell proliferation and differentiation (Luscher and Eisenman, 1991; Marcu et al. 1992) and can induce apoptosis (Askew et al. 1991, 1993; Evan et al. 1992; Bissonette et al....
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
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abstract::Xenotransplantation is a public health concern because it has the potential to infect human recipients with zoonotic and other infectious agents that are not endemic in human populations, thereby potentially introducing new infections to the human community. From this perspective, xenotransplantation clinical trials c...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-55541-1_2
更新日期:2003-01-01 00:00:00
abstract::Mammalian orthoreoviruses (reoviruses) are prototype members of the Reoviridae family of nonenveloped viruses. Reoviruses contain ten double-stranded RNA gene segments enclosed in two concentric protein shells, outer capsid and core. These viruses serve as a versatile experimental system for studies of virus cell entr...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
abstract::CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
abstract::The "humanized mouse" is a mouse harboring functioning human tissues used as in vivo human models for both physiological and pathological conditions. The NOD/Shi-scid IL2rgamma(null) (NOG) mouse, an excellent immunodeficient mouse used as the basis for the humanized mouse, requires strict genetic and environmental con...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-27511-8_8
更新日期:2005-01-01 00:00:00
abstract::The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-26397-7_7
更新日期:2006-01-01 00:00:00