The clinical and pathophysiological features of malarial anaemia.

abstract：:The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...

journal_title：Current topics in microbiology and immunology

authors： Tracy S,Chapman NM,Drescher KM,Kono K,Tapprich W

更新日期：2006-01-01 00:00:00

abstract：:While more and more attention has been paid to CpG-DNA with respect to its usefulness as an adjuvant, its molecular mechanism of action is less well defined. Over the last few years, at least two major signalling pathways have been shown to be utilized by CpG-DNA: the NF-kappa B activation pathway and the stress-kinas...

journal_title：Current topics in microbiology and immunology

authors： Häcker H

更新日期：2000-01-01 00:00:00

abstract：:In view of the recent studies on the CDCs, a reasonable schematic of the stages leading to membrane insertion of the CDCs can be assembled. As shown in Fig. 3, we propose that the CDC first binds to the membrane as a monomer. These monomers then diffuse laterally on the membrane surface to encounter other monomers or ...

journal_title：Current topics in microbiology and immunology

authors： Tweten RK,Parker MW,Johnson AE

更新日期：2001-01-01 00:00:00

abstract：:Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit se...

journal_title：Current topics in microbiology and immunology

authors： Mittal J,Ponce MG,Gendlina I,Nosanchuk JD

更新日期：2019-01-01 00:00:00

abstract：:Phosphoinositide 3-kinases (PI 3-kinases) are activated by growth factor and hormone receptors, and regulate cell growth, survival, motility, and responses to changes in nutritional conditions (Engelman et al. 2006). PI 3-kinases have been classified according to their subunit composition and their substrate specifici...

journal_title：Current topics in microbiology and immunology

authors： Backer JM

更新日期：2010-01-01 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen, responsible for infections in the community and the healthcare setting. Although much of the attention is focused on the methicillin-resistant "variant" MRSA, the methicillin-susceptible counterpart (MSSA) remains a prime species in infections. The epidemiology of ...

journal_title：Current topics in microbiology and immunology

authors： Monaco M,Pimentel de Araujo F,Cruciani M,Coccia EM,Pantosti A

更新日期：2017-01-01 00:00:00

abstract：:Our knowledge of the organization and regulation of the murine hematopoietic stem cell hierarchy has, in large measure, been the result of the development of in vivo reconstitution assays for cells of various levels of differentiation. For example, many basic stem cell concepts were established using CFU-S as a paradi...

journal_title：Current topics in microbiology and immunology

authors： Dick JE

更新日期：1989-01-01 00:00:00

abstract：:In normal cells, the proto-oncogene c-myc is regulated by promoter-proximal pausing of RNA polymerase II (pol II). In Burkitt lymphoma cells, c-myc is chromosomally translocated to one of the three immunoglobulin (Ig) gene loci and its transcription is driven constitutively by Ig enhancers. Promoter-proximal pausing o...

journal_title：Current topics in microbiology and immunology

authors： Schneider EE,Albert T,Wolf DA,Eick D

更新日期：1999-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world's population. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent grow...

journal_title：Current topics in microbiology and immunology

authors： Hislop AD,Taylor GS

更新日期：2015-01-01 00:00:00

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:Single-cell technologies like mass cytometry enable researchers to comprehensively monitor signaling network responses in the context of heterogeneous cell populations. Cell-to-cell variability, the possibly nonlinear topology of signaling processes, and the destructive nature of mass cytometry necessitate nontrivial ...

journal_title：Current topics in microbiology and immunology

authors： Claassen M

更新日期：2014-01-01 00:00:00

abstract：:Collective knowledge regarding the occurrence of influenza among swine is incomplete due to inconsistent surveillance of swine populations. In this chapter, we review what surveillance activities exist and some of the practical challenges encountered. Furthermore, to support robust surveillance activities, accurate la...

journal_title：Current topics in microbiology and immunology

authors： Detmer S,Gramer M,Goyal S,Torremorell M,Torrison J

更新日期：2013-01-01 00:00:00

abstract：:The antiquated system used to manufacture the currently licensed inactivated influenza virus vaccines would not be adequate during an influenza virus pandemic. There is currently a search for vaccines that can be developed faster and provide superior, long-lasting immunity to influenza virus as well as other highly pa...

journal_title：Current topics in microbiology and immunology

authors： Kopecky-Bromberg SA,Palese P

更新日期：2009-01-01 00:00:00

abstract：:The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments includ...

journal_title：Current topics in microbiology and immunology

authors： Hendriks A,Cruz AR,Soldaini E,Manetti AGO,Bagnoli F

更新日期：2018-09-20 00:00:00

abstract：:The global need for a pandemic influenza vaccine is large. High-income countries have stated their intent to provide universal access for pandemic influenza vaccine to their populations. Assuming that a two-dose schedule would be needed, providing universal coverage globally would represent approximately 6.5 billion t...

journal_title：Current topics in microbiology and immunology

authors： Edwards KM,Sabow A,Pasternak A,Boslego JW

更新日期：2009-01-01 00:00:00

abstract：:The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...

journal_title：Current topics in microbiology and immunology

authors： Offringa R,de Jong A,Toes RE,van der Burg SH,Melief CJ

更新日期：2003-01-01 00:00:00

abstract：:Every enveloped virus fuses its membrane with a host cell membrane, thereby releasing its genome into the cytoplasm and initiating the viral replication cycle. In each case, one or a small set of viral surface transmembrane glycoproteins mediates fusion. Viral fusion proteins vary in their mode of activation and in st...

journal_title：Current topics in microbiology and immunology

authors： Earp LJ,Delos SE,Park HE,White JM

更新日期：2005-01-01 00:00:00

abstract：:The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma ...

journal_title：Current topics in microbiology and immunology

authors： Klahn P,Brönstrup M

更新日期：2016-01-01 00:00:00

abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...

journal_title：Current topics in microbiology and immunology

authors： Gosztonyi G,Ludwig H

更新日期：1995-01-01 00:00:00

abstract：:The increased risk for severe dengue disease during secondary dengue virus (DENV) infections, along with the clinical and pathological evidence pointing to cytokines as the proximal mediators of disease, has interested cellular immunologists in exploring the role of DENV-specific T lymphocytes in the pathogenesis of d...

journal_title：Current topics in microbiology and immunology

authors： Rothman AL

更新日期：2010-01-01 00:00:00

abstract：:The field of autophagy research has advanced rapidly in recent years, with important discoveries made in relation to both molecular mechanisms and physiological functions. Initially, autophagy was thought to be primarily a response to starvation. Although this might be true in lower eukaryotes, this catabolic process ...

journal_title：Current topics in microbiology and immunology

authors： Mizushima N

更新日期：2009-01-01 00:00:00

abstract：:Influenza vaccines are the mainstay of efforts to reduce the substantial health burden from seasonal influenza. Inactivated influenza vaccines have been available since the 1940s and are administered via intramuscular injection. Inactivated vaccines can be given to anyone six months of age or older. Live attenuated, c...

journal_title：Current topics in microbiology and immunology

authors： Fiore AE,Bridges CB,Cox NJ

更新日期：2009-01-01 00:00:00

abstract：:Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model. Multiple mechanisms of activation of c-myb by retroviral insertional mutagenesis implicate both transcriptional deregulation...

journal_title：Current topics in microbiology and immunology

authors： Wolff L,Koller R,Bies J,Nazarov V,Hoffman B,Amanullah A,Krall M,Mock B

更新日期：1996-01-01 00:00:00

abstract：:Commercial vaccines currently available against swine influenza virus (SIV) are inactivated, adjuvanted, whole virus vaccines, based on H1N1 and/or H3N2 and/or H1N2 SIVs. In keeping with the antigenic and genetic differences between SIVs circulating in Europe and the US, the vaccines for each region are produced local...

journal_title：Current topics in microbiology and immunology

authors： Van Reeth K,Ma W

更新日期：2013-01-01 00:00:00

abstract：:Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of th...

journal_title：Current topics in microbiology and immunology

authors： Roy CJ,Song K,Sivasubramani SK,Gardner DJ,Pincus SH

更新日期：2012-01-01 00:00:00

abstract：:Chloroplast genetic engineering offers several advantages, including high levels of transgene expression, transgene containment via maternal inheritance, and multi-gene expression in a single transformation event. Oral delivery is facilitated by hyperexpression of vaccine antigens against cholera, tetanus, anthrax, pl...

journal_title：Current topics in microbiology and immunology

authors： Chebolu S,Daniell H

更新日期：2009-01-01 00:00:00

abstract：:Bacterial polysaccharides play an essential role in cell viability, virulence, and evasion of host defenses. Although the polysaccharides themselves are highly diverse, the pathways by which bacteria synthesize these essential polymers are conserved in both Gram-negative and Gram-positive organisms. By utilizing a lip...

journal_title：Current topics in microbiology and immunology

authors： Taylor VL,Huszczynski SM,Lam JS

更新日期：2017-01-01 00:00:00

abstract：:The family of protein tyrosine phosphatases (PTPs) includes 107 genes in humans that are diverse in their structures and expression profiles. The majority are present in immune cells and play various roles in either inhibiting or promoting the duration and amplitude of signaling cascades. Several PTPs, including TC-PT...

journal_title：Current topics in microbiology and immunology

authors： Penafuerte C,Perez-Quintero LA,Vinette V,Hatzihristidis T,Tremblay ML

更新日期：2017-01-01 00:00:00

abstract：:The collaboration between Alick Isaacs and myself started in the summer of 1956. Our initial project was to show, by electron microscopy, that interference between inactivated influenza virus and live virus involved the transfer of material from the interfering virus to the host cell. This approach failed for technica...

journal_title：Current topics in microbiology and immunology

authors： Lindenmann J

更新日期：2007-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00