The role of ornithine decarboxylase in c-Myc-induced apoptosis.

abstract：:Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its targe...

journal_title：Current topics in microbiology and immunology

authors： Hagman J,Ramírez J,Lukin K

更新日期：2012-01-01 00:00:00

abstract：:The capacity of varicella zoster virus (VZV) to cause varicella (chickenpox) relies upon multiple steps, beginning with inoculation of the host at mucosal sites with infectious virus in respiratory droplets. Despite the presence of a powerful immune defense system, this virus is able to disseminate from the site of in...

journal_title：Current topics in microbiology and immunology

authors： Abendroth A,Kinchington PR,Slobedman B

更新日期：2010-01-01 00:00:00

abstract：:Chloroplast genetic engineering offers several advantages, including high levels of transgene expression, transgene containment via maternal inheritance, and multi-gene expression in a single transformation event. Oral delivery is facilitated by hyperexpression of vaccine antigens against cholera, tetanus, anthrax, pl...

journal_title：Current topics in microbiology and immunology

authors： Chebolu S,Daniell H

更新日期：2009-01-01 00:00:00

abstract：:Recombinant protein- and peptide-based vaccines can deliver large amounts of specific antigens for tailored immune responses. One class of these are protein and peptide nanoclusters (PNCs), which are made entirely from the crosslinked antigen. PNCs leverage the inherent immunogenicity of nanoparticulate antigens while...

journal_title：Current topics in microbiology and immunology

authors： Chang TZ,Champion JA

更新日期：2020-11-10 00:00:00

abstract：:Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it ...

journal_title：Current topics in microbiology and immunology

authors： Blondel B,Colbère-Garapin F,Couderc T,Wirotius A,Guivel-Benhassine F

更新日期：2005-01-01 00:00:00

abstract：:Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....

journal_title：Current topics in microbiology and immunology

authors： Ota T,Sitnikova T,Nei M

更新日期：2000-01-01 00:00:00

abstract：:In view of the recent studies on the CDCs, a reasonable schematic of the stages leading to membrane insertion of the CDCs can be assembled. As shown in Fig. 3, we propose that the CDC first binds to the membrane as a monomer. These monomers then diffuse laterally on the membrane surface to encounter other monomers or ...

journal_title：Current topics in microbiology and immunology

authors： Tweten RK,Parker MW,Johnson AE

更新日期：2001-01-01 00:00:00

abstract：:The antiquated system used to manufacture the currently licensed inactivated influenza virus vaccines would not be adequate during an influenza virus pandemic. There is currently a search for vaccines that can be developed faster and provide superior, long-lasting immunity to influenza virus as well as other highly pa...

journal_title：Current topics in microbiology and immunology

authors： Kopecky-Bromberg SA,Palese P

更新日期：2009-01-01 00:00:00

abstract：:Host cell attachment by influenza A viruses is mediated by the hemagglutinin glycoprotein (HA), and the recognition of specific types of sialic acid -containing glycan receptors constitutes one of the major determinants of viral host range and transmission properties. Structural studies have elucidated some of the vir...

journal_title：Current topics in microbiology and immunology

authors： Xiong X,McCauley JW,Steinhauer DA

更新日期：2014-01-01 00:00:00

abstract：:Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of th...

journal_title：Current topics in microbiology and immunology

authors： Roy CJ,Song K,Sivasubramani SK,Gardner DJ,Pincus SH

更新日期：2012-01-01 00:00:00

abstract：:Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with bo...

journal_title：Current topics in microbiology and immunology

authors： Orvedahl A,Levine B

更新日期：2009-01-01 00:00:00

abstract：:Negative-strand RNA virus particles are formed by a process that includes the assembly of viral components at the plasma membranes of infected cells and the subsequent release of particles by budding. Here, we review recent progress that has been made in understanding the mechanisms of negative-strand RNA virus assemb...

journal_title：Current topics in microbiology and immunology

authors： Schmitt AP,Lamb RA

更新日期：2004-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world's population. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent grow...

journal_title：Current topics in microbiology and immunology

authors： Hislop AD,Taylor GS

更新日期：2015-01-01 00:00:00

abstract：:Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts in...

journal_title：Current topics in microbiology and immunology

authors： Broder CC,Geisbert TW,Xu K,Nikolov DB,Wang LF,Middleton D,Pallister J,Bossart KN

更新日期：2012-01-01 00:00:00

abstract：:The Picornaviridae encompass many positive-strand RNA viruses, all of which share a generally similar genome design and capsid structure, but which induce quite diverse diseases in humans and other animals. Picornavirus strains of the same serotype have been shown to express different virulence (or pathogenic) phenoty...

journal_title：Current topics in microbiology and immunology

authors： Tracy S,Chapman NM,Drescher KM,Kono K,Tapprich W

更新日期：2006-01-01 00:00:00

abstract：:Swine influenza is a continual problem for the Swine industry and can pose a public health threat as evidenced by the 2009 H1N1 influenza virus pandemic. Given its importance, it is not surprising to find papers describing the disease from the early 20th century. In this chapter, we discuss the history of Swine influe...

journal_title：Current topics in microbiology and immunology

authors： Schultz-Cherry S,Olsen CW,Easterday BC

更新日期：2013-01-01 00:00:00

abstract：:Until about 15 years ago, the molecular and cellular basis for pathogenesis in leptospirosis was virtually unknown. The determination of the first full genome sequence in 2003 was followed rapidly by other whole genome sequences, whose availability facilitated the development of transposon mutagenesis and then directe...

journal_title：Current topics in microbiology and immunology

authors： Bulach D,Adler B

更新日期：2018-01-01 00:00:00

abstract：:It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes ...

journal_title：Current topics in microbiology and immunology

authors： Johannesson M,Hultqvist M,Holmdahl R

更新日期：2006-01-01 00:00:00

abstract：:The varicella-zoster virus (VZV) open reading frame (ORF) 66 encodes a basophilic kinase orthologous to the US3 protein kinases found in all alphaherpesviruses. This review summarizes current information on the ORF66 kinase, and outlines apparent differences from other US3 kinases, as well as some of the conserved fun...

journal_title：Current topics in microbiology and immunology

authors： Erazo A,Kinchington PR

更新日期：2010-01-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiate...

journal_title：Current topics in microbiology and immunology

authors： Takeuchi O,Akira S

更新日期：2002-01-01 00:00:00

abstract：:HAM/TSP is a chronic inflammatory disease of the spinal cord. It is rather rare in HTLV-1-infected individuals. Immunogenetic factors of the HLA complex have been identified that support or prevent the development of the disease. In HAM/TSP patients a characteristic constellation of high proviral loads and increased c...

journal_title：Current topics in microbiology and immunology

authors： Kitze B,Usuku K

更新日期：2002-01-01 00:00:00

abstract：:The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the ami...

journal_title：Current topics in microbiology and immunology

authors： Amoasii L,Hnia K,Laporte J

更新日期：2012-01-01 00:00:00

abstract：:Tumor DNA contains valuable clues about the origin and pathogenesis of human cancers. Alterations in DNA methylation can lead to silencing of genes associated with distinct tumorigenic pathways. These pathway-specific DNA methylation changes help define tumor-specific DNA methylation profiles that can be used to furth...

journal_title：Current topics in microbiology and immunology

authors： Campan M,Weisenberger DJ,Laird PW

更新日期：2006-01-01 00:00:00

abstract：:Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...

journal_title：Current topics in microbiology and immunology

authors： Steinman L,Utz PJ,Robinson WH

更新日期：2005-01-01 00:00:00

abstract：:Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermo...

journal_title：Current topics in microbiology and immunology

authors： Horiguchi Y

更新日期：2012-01-01 00:00:00

abstract：:Measles ranks fifth among the five major childhood conditions which are responsible for 21% of all deaths in low and middle-income countries. Measles immunization is considered the most cost-effective public health intervention in the world. In recent years, there has been a critical need to identify alternative route...

journal_title：Current topics in microbiology and immunology

authors： Valdespino-Gómez JL,de Lourdes Garcia-Garcia M,Fernandez-de-Castro J,Henao-Restrepo AM,Bennett J,Sepulveda-Amor J

更新日期：2006-01-01 00:00:00

abstract：:Every enveloped virus fuses its membrane with a host cell membrane, thereby releasing its genome into the cytoplasm and initiating the viral replication cycle. In each case, one or a small set of viral surface transmembrane glycoproteins mediates fusion. Viral fusion proteins vary in their mode of activation and in st...

journal_title：Current topics in microbiology and immunology

authors： Earp LJ,Delos SE,Park HE,White JM

更新日期：2005-01-01 00:00:00

abstract：:Torque teno (TT) viruses have been more frequently reported in malignant biopsies when compared to normal control tissue. The possible contribution of TT virus infection to human carcinogenesis or the potential oncolytic functions of these virus infections are being discussed based on available experimental evidence. ...

journal_title：Current topics in microbiology and immunology

authors： zur Hausen H,de Villiers EM

更新日期：2009-01-01 00:00:00

abstract：:Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches...

journal_title：Current topics in microbiology and immunology

authors： Wagner N,Atsmon-Raz Y,Ashkenasy G

更新日期：2016-01-01 00:00:00

abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...

journal_title：Current topics in microbiology and immunology

authors： Moss WJ

更新日期：2009-01-01 00:00:00