Basic concept of development and practical application of animal models for human diseases.

Abstract:

:The "humanized mouse" is a mouse harboring functioning human tissues used as in vivo human models for both physiological and pathological conditions. The NOD/Shi-scid IL2rgamma(null) (NOG) mouse, an excellent immunodeficient mouse used as the basis for the humanized mouse, requires strict genetic and environmental control for production and use in experiments. Genetic control using marker-assisted selection is described. In addition, NOG mice are easily affected by microbiological and proximate environmental factors, which can cause severe damage to the mice in some cases. Therefore, rigorous microbiological and environmental controls are necessary to ensure reproducibility of experimental results. At the end of this chapter, future aspects of the application of "humanized mice" based on novel super-immunodeficient mice such as NOG mice and Rag2(null) IL2rgamma(null) mice in biomedical research and testing are briefly reviewed.

authors

Nomura T,Tamaoki N,Takakura A,Suemizu H

doi

10.1007/978-3-540-75647-7_1

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

1-24

eissn

0070-217X

issn

2196-9965

journal_volume

324

pub_type

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