Abstract:
:Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T cell activation by APCs and immunological synapse formation. This review summarizes recent advances in our understanding of how Rho GTPase-dependent pathways control T lymphocyte motility, polarization and activation.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Deckert M,Moon C,Le Bras Sdoi
10.1007/3-540-27511-8_5subject
Has Abstractpub_date
2005-01-01 00:00:00pages
61-90eissn
0070-217Xissn
2196-9965journal_volume
291pub_type
杂志文章,评审abstract::Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...
journal_title:Current topics in microbiology and immunology
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abstract::Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of th...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/82_2011_173
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abstract::Until about 15 years ago, the molecular and cellular basis for pathogenesis in leptospirosis was virtually unknown. The determination of the first full genome sequence in 2003 was followed rapidly by other whole genome sequences, whose availability facilitated the development of transposon mutagenesis and then directe...
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journal_title:Current topics in microbiology and immunology
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doi:10.1007/82_2014_362
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abstract::The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2017_41
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...
journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
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abstract::Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts in...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-70962-6_13
更新日期:2007-01-01 00:00:00
abstract::In normal cells, the proto-oncogene c-myc is regulated by promoter-proximal pausing of RNA polymerase II (pol II). In Burkitt lymphoma cells, c-myc is chromosomally translocated to one of the three immunoglobulin (Ig) gene loci and its transcription is driven constitutively by Ig enhancers. Promoter-proximal pausing o...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/82_2020_229
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2015_483
更新日期:2016-01-01 00:00:00
abstract::Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::The capacity of varicella zoster virus (VZV) to cause varicella (chickenpox) relies upon multiple steps, beginning with inoculation of the host at mucosal sites with infectious virus in respiratory droplets. Despite the presence of a powerful immune defense system, this virus is able to disseminate from the site of in...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::The genetic differences that potentially account for the attenuation of the Oka vaccine VZV preparation are more clearly defined than for perhaps any other vaccine in current use. This is due in large part to the small number of differences between the vaccine and the parental strain from which it was derived, and to ...
journal_title:Current topics in microbiology and immunology
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journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2019_192
更新日期:2020-01-01 00:00:00
abstract::In view of the recent studies on the CDCs, a reasonable schematic of the stages leading to membrane insertion of the CDCs can be assembled. As shown in Fig. 3, we propose that the CDC first binds to the membrane as a monomer. These monomers then diffuse laterally on the membrane surface to encounter other monomers or ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::Measles virus (MV) has two envelope glycoproteins, the hemagglutinin (H) and fusion protein, which are responsible for attachment and membrane fusion, respectively. Signaling lymphocyte activation molecule (SLAM, also called CD150), a membrane glycoprotein expressed on immune cells, acts as the principal cellular rece...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-70523-9_2
更新日期:2009-01-01 00:00:00
abstract::The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
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abstract::The Gram-negative bacterium Helicobacter pylori is predominantly known for its tight association with peptic ulcer disease and gastric cancer development. However, recent epidemiological and experimental evidence suggests that chronic infection with H. pylori may at the same time be beneficial to the host by conferrin...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-50520-6_14
更新日期:2017-01-01 00:00:00