Predictive genomic biomarkers.

abstract：:Leptospires are spirochetes that may be free-living saprophytes found in freshwater or may cause acute or chronic infection of animals. The family Leptospiraceae comprises three genera: Leptospira Leptospira Leptonema Leptonema, and Turneriella Turneriella. Within the genus Leptospira, three clades can be distinguishe...

journal_title：Current topics in microbiology and immunology

authors： Levett PN

更新日期：2015-01-01 00:00:00

abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...

journal_title：Current topics in microbiology and immunology

authors： Mason HS,Herbst-Kralovetz MM

更新日期：2012-01-01 00:00:00

abstract：:Certain vertebrates are capable of regenerating parts of the eye, including the lens. Depending on the species, two principal forms of in vivo lens regeneration have been described wherein the new lens arises from either the pigmented epithelium of the dorsal iris or the cornea epithelium. These forms of lens regenera...

journal_title：Current topics in microbiology and immunology

authors： Henry JJ,Thomas AG,Hamilton PW,Moore L,Perry KJ

更新日期：2013-01-01 00:00:00

abstract：:Natural and intentional biological risks threaten human civilization, both through direct human fatality as well as follow-on effects from a collapse of the just-in-time delivery system that provides food, energy and critical supplies to communities globally. Human beings have multiple innate cognitive biases that sys...

journal_title：Current topics in microbiology and immunology

authors： Luby S,Arthur R

更新日期：2019-01-01 00:00:00

abstract：:In most cases, the genetic engineering of plants uses Agrobacterium-mediated transformation to introduce novel genes. In nature, insertion of T-DNA into the plant genome and its subsequent transfer via sexual reproduction have been shown for several species in the genera Nicotiana, Ipomoea , and Linaria . A sequence h...

journal_title：Current topics in microbiology and immunology

authors： Matveeva TV

更新日期：2018-01-01 00:00:00

abstract：:Natural killer (NK) cells are crucial to mounting an effective immune response. They have a significant role in cancer immunosurveillance and function as a bridge between innate and adaptive immunity. However, until recently, surprisingly little was known about the molecular basis of NK cell development as compared to...

journal_title：Current topics in microbiology and immunology

authors： Male V,Brady HJ

更新日期：2014-01-01 00:00:00

abstract：:Torque teno (TT) viruses have been more frequently reported in malignant biopsies when compared to normal control tissue. The possible contribution of TT virus infection to human carcinogenesis or the potential oncolytic functions of these virus infections are being discussed based on available experimental evidence. ...

journal_title：Current topics in microbiology and immunology

authors： zur Hausen H,de Villiers EM

更新日期：2009-01-01 00:00:00

abstract：:The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the ami...

journal_title：Current topics in microbiology and immunology

authors： Amoasii L,Hnia K,Laporte J

更新日期：2012-01-01 00:00:00

abstract：:Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it ...

journal_title：Current topics in microbiology and immunology

authors： Blondel B,Colbère-Garapin F,Couderc T,Wirotius A,Guivel-Benhassine F

更新日期：2005-01-01 00:00:00

abstract：:Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the ...

journal_title：Current topics in microbiology and immunology

authors： Niedermann G

更新日期：2002-01-01 00:00:00

abstract：:Evolution of Ig V gene segments are generally characterized by (a) evolution by "the birth and death process" and (b) diversifying selection. However, the detailed evolutionary pattern of V gene segments varies among species due to the fact that the humoral immune system itself has changed during vertebrate evolution....

journal_title：Current topics in microbiology and immunology

authors： Ota T,Sitnikova T,Nei M

更新日期：2000-01-01 00:00:00

abstract：:Autoimmune gastritis (AIG) is an experimental model that closely resembles human autoimmune gastritis, the underlying pathology of pernicious anemia. Pathogenic CD4+ T cells are reactive to the parietal cell autoantigen, H/K ATPase, and are controlled by CD4+CD25+ T cells in an immunosuppressive cytokine-independent m...

journal_title：Current topics in microbiology and immunology

authors： McHugh RS

更新日期：2005-01-01 00:00:00

abstract：:Mammalian orthoreoviruses (reoviruses) are prototype members of the Reoviridae family of nonenveloped viruses. Reoviruses contain ten double-stranded RNA gene segments enclosed in two concentric protein shells, outer capsid and core. These viruses serve as a versatile experimental system for studies of virus cell entr...

journal_title：Current topics in microbiology and immunology

authors： Danthi P,Guglielmi KM,Kirchner E,Mainou B,Stehle T,Dermody TS

更新日期：2010-01-01 00:00:00

abstract：:In conventionally reared mice germinal centers (GCs) are chronically induced in Peyer's patches (PP), mesenteric lymph node (MLN), and isolated lymphoid follicles (ILF) of gut-associated lymphoid tissues (GALT), as a result of continuous B cell stimulation by commensal bacteria. It is generally thought that BCR-mediat...

journal_title：Current topics in microbiology and immunology

authors： Casola S,Rajewsky K

更新日期：2006-01-01 00:00:00

abstract：:Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with bo...

journal_title：Current topics in microbiology and immunology

authors： Orvedahl A,Levine B

更新日期：2009-01-01 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen, responsible for infections in the community and the healthcare setting. Although much of the attention is focused on the methicillin-resistant "variant" MRSA, the methicillin-susceptible counterpart (MSSA) remains a prime species in infections. The epidemiology of ...

journal_title：Current topics in microbiology and immunology

authors： Monaco M,Pimentel de Araujo F,Cruciani M,Coccia EM,Pantosti A

更新日期：2017-01-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) perform diverse regulatory functions in transcription, translation' chromatin modification, and cellular organization. Misregulation of lncRNAs is found linked to various human diseases. Compared to protein-coding RNAs' lncRNAs are more specific to organs, tissues, cell types, development...

journal_title：Current topics in microbiology and immunology

authors： Nguyen Q,Carninci P

更新日期：2016-01-01 00:00:00

abstract：:B. anthracis virulence is the sum of the contributions of factors involved in toxicity, growth and persistence in the host. Recent data has revealed that the interactions between B. anthracis and macrophage is central to the B. anthracis pathogenesis. This review presents and describes tactics by which B. anthracis no...

journal_title：Current topics in microbiology and immunology

authors： Guidi-Rontani C,Mock M

更新日期：2002-01-01 00:00:00

abstract：:Protein synthesis requires nutrients both as precursors (amino acids) and as a source of energy, since this process consumes a high proportion of cellular metabolic energy. Recent work has shown that both types of nutrients directly influence the activities of components of the translational machinery in mammalian cel...

journal_title：Current topics in microbiology and immunology

authors： Proud CG

更新日期：2004-01-01 00:00:00

abstract：:The genetic differences that potentially account for the attenuation of the Oka vaccine VZV preparation are more clearly defined than for perhaps any other vaccine in current use. This is due in large part to the small number of differences between the vaccine and the parental strain from which it was derived, and to ...

journal_title：Current topics in microbiology and immunology

authors： Schmid DS

更新日期：2010-01-01 00:00:00

abstract：:Yersinia entercolitica and Yersinia pseudotuberculosis are human foodborne pathogens that interact extensively with tissues of the gut and the host's immune system to cause disease. As part of their pathogenic strategies, the Yersinia have evolved numerous ways to invade host tissues, gain essential nutrients, and eva...

journal_title：Current topics in microbiology and immunology

authors： Dube P

更新日期：2009-01-01 00:00:00

abstract：:Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily on the mode of action of these toxins. More recently, studies have addressed the molecular interactions of these toxins with host cell signaling pathways and how toxins modulate cellular physiology. Although each individual ...

journal_title：Current topics in microbiology and immunology

authors： Baldwin MR,Barbieri JT

更新日期：2005-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world's population. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent grow...

journal_title：Current topics in microbiology and immunology

authors： Hislop AD,Taylor GS

更新日期：2015-01-01 00:00:00

abstract：:Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that mol...

journal_title：Current topics in microbiology and immunology

authors： Frolov I,Frolova EI

更新日期：2019-01-01 00:00:00

abstract：:The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments includ...

journal_title：Current topics in microbiology and immunology

authors： Hendriks A,Cruz AR,Soldaini E,Manetti AGO,Bagnoli F

更新日期：2018-09-20 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor alpha (RARa) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARalpha fuses to the PML gene in the majority of APL cases, and in a few...

journal_title：Current topics in microbiology and immunology

authors： Scaglioni PP,Pandolfi PP

更新日期：2007-01-01 00:00:00

abstract：:After infection of a cell, the positive-strand RNA genome of Hepatitis C Virus (HCV) directly serves as the template for translation in the cytosol. By the use of an internal ribosome entry site (IRES) element in the 5'-untranslated region (5'-UTR) of the viral RNA, the HCV RNA bypasses the need for nuclear processing...

journal_title：Current topics in microbiology and immunology

authors： Niepmann M

更新日期：2013-01-01 00:00:00

abstract：:DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the ho...

journal_title：Current topics in microbiology and immunology

authors： Zawilak-Pawlik A,Zakrzewska-Czerwińska J

更新日期：2017-01-01 00:00:00

abstract：:This chapter highlights the cholera situation in South Asia and the Bay of Bengal region, the original 'homeland' of cholera. A detailed discussion of cholera outbreaks in individual countries in South-East Asia follows. The countries of the World Health Organization (WHO) SEARO (South-East Asia Region) region are dis...

journal_title：Current topics in microbiology and immunology

authors： Bharati K,Bhattacharya SK

更新日期：2014-01-01 00:00:00