Abstract:
:The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses with genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms. These dynamic and highly organized structures serve as viral factories that direct the packaging and replication of the viral genome into early capsid assembly intermediates. Migration of the intermediates to the endoplasmic reticulum (ER) initiates a budding process that culminates in final capsid assembly. Recent information on the development and organization of viroplasms, the structure and function of its components, and interactive pathways linking RNA synthesis and capsid assembly provide new insight into how these microenvironments serve to interface the replication and morphogenetic processes of the virus.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Patton JT,Silvestri LS,Tortorici MA,Vasquez-Del Carpio R,Taraporewala ZFdoi
10.1007/3-540-30773-7_6subject
Has Abstractpub_date
2006-01-01 00:00:00pages
169-87eissn
0070-217Xissn
2196-9965journal_volume
309pub_type
杂志文章,评审abstract::Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis (Mtb) and represents one of the most relevant bacterial diseases worldwide. Recent advances have yielded new insights into the molecular basis of the immune response required for restriction of the pathogen and also highlighted determinants of im...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-41171-2_9
更新日期:2016-01-01 00:00:00
abstract::The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its ta...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2010_76
更新日期:2010-01-01 00:00:00
abstract::The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways u...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-07911-0_18
更新日期:2014-01-01 00:00:00
abstract::Until about 15 years ago, the molecular and cellular basis for pathogenesis in leptospirosis was virtually unknown. The determination of the first full genome sequence in 2003 was followed rapidly by other whole genome sequences, whose availability facilitated the development of transposon mutagenesis and then directe...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2018_87
更新日期:2018-01-01 00:00:00
abstract::Production of type I IFN is the key response to viral infection. Since the discovery of type I IFNs in 1957, long double-stranded RNA formed during replication of many viruses was thought to be responsible for type I IFN induction, and for decades double-stranded RNA-activated protein kinase (PKR) was thought to be th...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-71329-6_11
更新日期:2007-01-01 00:00:00
abstract::Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specif...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2011_164
更新日期:2012-01-01 00:00:00
abstract::Measles ranks fifth among the five major childhood conditions which are responsible for 21% of all deaths in low and middle-income countries. Measles immunization is considered the most cost-effective public health intervention in the world. In recent years, there has been a critical need to identify alternative route...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-36583-4_10
更新日期:2006-01-01 00:00:00
abstract::Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. I...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2017_23
更新日期:2017-01-01 00:00:00
abstract::The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth muscle cells are the predominant targets for virus ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-77349-8_4
更新日期:2008-01-01 00:00:00
abstract::Autoimmune gastritis (AIG) is an experimental model that closely resembles human autoimmune gastritis, the underlying pathology of pernicious anemia. Pathogenic CD4+ T cells are reactive to the parietal cell autoantigen, H/K ATPase, and are controlled by CD4+CD25+ T cells in an immunosuppressive cytokine-independent m...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-27702-1_8
更新日期:2005-01-01 00:00:00
abstract::The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2016_501
更新日期:2016-01-01 00:00:00
abstract::It has been estimated that there are more microorganisms within and upon the human body than there are human cells. By necessity, every accessible niche must be defended by innate mechanisms to prevent invasive infection, and ideally that precludes the need for robust inflammatory responses. Yet the potential for path...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/3-540-29916-5_5
更新日期:2006-01-01 00:00:00
abstract::Glucans are characteristic and major constituents of fungal cell walls. Depending on the species, different glucan polysaccharides can be found. These differ in the linkage of the D-glucose monomers which can be either in α- or β-conformation and form 1,3, 1,4 or 1,6 O-glycosidic bonds. The linkages and polymer length...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2020_200
更新日期:2020-01-01 00:00:00
abstract::Enzootic nasal adenocarcinoma is a contagious tumour of the mucosal nasal glands affecting young adult sheep or goats. The disease occurs naturally in all continents except Australia and New Zealand. Clinical signs include continuous nasal discharge, respiratory distress, exophthalmos and skull deformations. The tumou...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-55638-8_8
更新日期:2003-01-01 00:00:00
abstract::The low-resource environment deprives healthcare providers caring for patients with Ebola virus disease (EVD) of many of the means employed for the critically ill that are available in better resourced settings, such as advanced therapeutic interventions and abundant staff. In addition to these limitations may be adde...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2017_18
更新日期:2017-01-01 00:00:00
abstract::Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assemb...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-75157-1_4
更新日期:2008-01-01 00:00:00
abstract::Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine available. The development of safe GAS vaccines is challenging, researchers are confronted with obstacles such as the occurrence of many unique serotypes (there are greater than 150 M types), antigenic variation within the same serotype,...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_284
更新日期:2013-01-01 00:00:00
abstract::Torque teno (TT) viruses have been more frequently reported in malignant biopsies when compared to normal control tissue. The possible contribution of TT virus infection to human carcinogenesis or the potential oncolytic functions of these virus infections are being discussed based on available experimental evidence. ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-70972-5_7
更新日期:2009-01-01 00:00:00
abstract::The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2017_41
更新日期:2018-01-01 00:00:00
abstract::The field of autophagy research has advanced rapidly in recent years, with important discoveries made in relation to both molecular mechanisms and physiological functions. Initially, autophagy was thought to be primarily a response to starvation. Although this might be true in lower eukaryotes, this catabolic process ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-00302-8_3
更新日期:2009-01-01 00:00:00
abstract::Microbial biofilms are governed by an intricate interplay between physical-chemical factors and the physiological and genetic properties of the inhabiting microbes. Many of the physiological traits that are exhibited in a biofilm environment have been observed and studied previously in detail in planktonic cultures. H...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-75418-3_2
更新日期:2008-01-01 00:00:00
abstract::Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/978-3-642-72153-3_2
更新日期:1998-01-01 00:00:00
abstract::Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model. Multiple mechanisms of activation of c-myb by retroviral insertional mutagenesis implicate both transcriptional deregulation...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-85232-9_19
更新日期:1996-01-01 00:00:00
abstract::During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2011_158
更新日期:2012-01-01 00:00:00
abstract::The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-06508-2_10
更新日期:2003-01-01 00:00:00
abstract::Measles virus (MV) has two envelope glycoproteins, the hemagglutinin (H) and fusion protein, which are responsible for attachment and membrane fusion, respectively. Signaling lymphocyte activation molecule (SLAM, also called CD150), a membrane glycoprotein expressed on immune cells, acts as the principal cellular rece...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-70523-9_2
更新日期:2009-01-01 00:00:00
abstract::The CBA/N strain carries xid, a murine btk missense mutation that reduces peripheral B cell numbers. Using in vivo BrdU labeling and cytofluorimetry, we have compared the magnitude, production rates, and turnover rates of each B lineage subset in the marrow and periphery of CBA/Ca and CBA/N mice. Our results show the ...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章
doi:10.1007/978-3-642-57284-5_4
更新日期:2000-01-01 00:00:00
abstract::Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is hig...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2019_192
更新日期:2020-01-01 00:00:00
abstract::Genetic variation of the host significantly contributes to dramatic differences in the outcomes of natural infection with virulent Mycobacterium tuberculosis (MTB) in humans, as well as in experimental animal models. Host resistance to tuberculosis is a complex multifactorial genetic trait in which many genetic polymo...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/978-3-540-75203-5_6
更新日期:2008-01-01 00:00:00
abstract::Hendra virus, a novel and fatally zoonotic member of the family Paramyxoviridae, was first described in Australia in 1994. Periodic spillover from its natural host (fruit bats) results in catastrophic disease in horses and occasionally the subsequent infection of humans. Prior to 2011, 14 equine incidents involving se...
journal_title:Current topics in microbiology and immunology
pub_type: 杂志文章,评审
doi:10.1007/82_2012_214
更新日期:2012-01-01 00:00:00