Group a streptococcal vaccine candidates: potential for the development of a human vaccine.

abstract：:The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses with genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms. These dynamic and highly organized...

journal_title：Current topics in microbiology and immunology

authors： Patton JT,Silvestri LS,Tortorici MA,Vasquez-Del Carpio R,Taraporewala ZF

更新日期：2006-01-01 00:00:00

abstract：:Protein synthesis requires nutrients both as precursors (amino acids) and as a source of energy, since this process consumes a high proportion of cellular metabolic energy. Recent work has shown that both types of nutrients directly influence the activities of components of the translational machinery in mammalian cel...

journal_title：Current topics in microbiology and immunology

authors： Proud CG

更新日期：2004-01-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell,...

journal_title：Current topics in microbiology and immunology

authors： Skoberne M,Beignon AS,Larsson M,Bhardwaj N

更新日期：2005-01-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiate...

journal_title：Current topics in microbiology and immunology

authors： Takeuchi O,Akira S

更新日期：2002-01-01 00:00:00

abstract：:CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental ...

journal_title：Current topics in microbiology and immunology

authors： Tanaka H,Taniuchi I

更新日期：2014-01-01 00:00:00

abstract：:The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that ...

journal_title：Current topics in microbiology and immunology

authors： Lindemann D,Goepfert PA

更新日期：2003-01-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-...

journal_title：Current topics in microbiology and immunology

authors： Reyes-Robles T,Torres VJ

更新日期：2017-01-01 00:00:00

abstract：:The incidence of Kaposi sarcoma (KS) related to Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) after organ transplantation is 500-1000 times greater than in the general population, and its occurrence is associated with immunosuppressive therapy. The reported incidence of posttransplant KS ranges from 0.5% to 5%, d...

journal_title：Current topics in microbiology and immunology

authors： Marcelin AG,Calvez V,Dussaix E

更新日期：2007-01-01 00:00:00

abstract：:Since MRD is the major cause for relapses of malignant diseases, strategies utilizing ITs to target tumor cells surviving conventional treatment have attracted scientific and clinical interest. Many different ITs against various blood-borne as well as solid malignancies have demonstrated specific potent anti-tumor eff...

journal_title：Current topics in microbiology and immunology

authors： Engert A,Sausville EA,Vitetta E

更新日期：1998-01-01 00:00:00

abstract：:Group A streptococcal (Streptococcus pyogenes) infections remain important causes of medical and public health morbidity and mortality even during the early twenty-first century. Although most often concentrated in socially/economically disadvantaged populations, the problems remain significant in both industrializing...

journal_title：Current topics in microbiology and immunology

authors： Kaplan EL

更新日期：2013-01-01 00:00:00

abstract：:The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the ...

journal_title：Current topics in microbiology and immunology

authors： Dash P,Thomas PG

更新日期：2015-01-01 00:00:00

abstract：:Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. Recent studies indicate the TOR (target of rapamycin) kinase acts within an intracellular regulatory network used by eukaryotic cells to regulate their growth according to nutrient availability. Th...

journal_title：Current topics in microbiology and immunology

authors： Powers T,Dilova I,Chen CY,Wedaman K

更新日期：2004-01-01 00:00:00

abstract：:The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described ...

journal_title：Current topics in microbiology and immunology

authors： Refsland EW,Harris RS

更新日期：2013-01-01 00:00:00

abstract：:IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 levels and a strong infiltration of IgG4-positive plasma cells in various organs. IgG4-RD patients also frequently suffer from allergic diseases, including asthma and atopic dermatitis. It is well known that T helper type 2 (Th2)...

journal_title：Current topics in microbiology and immunology

authors： Moriyama M,Nakamura S

更新日期：2017-01-01 00:00:00

abstract：:The fibroblast growth factor (FGF) family contains 23 members in mammals including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation of many key cellular responses involved in developmental and physiological processes. These includes proliferation, differentiation, migration, apoptosis, an...

journal_title：Current topics in microbiology and immunology

authors： Wiedłocha A,Sørensen V

更新日期：2004-01-01 00:00:00

abstract：:Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts in...

journal_title：Current topics in microbiology and immunology

authors： Broder CC,Geisbert TW,Xu K,Nikolov DB,Wang LF,Middleton D,Pallister J,Bossart KN

更新日期：2012-01-01 00:00:00

abstract：:The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments includ...

journal_title：Current topics in microbiology and immunology

authors： Hendriks A,Cruz AR,Soldaini E,Manetti AGO,Bagnoli F

更新日期：2018-09-20 00:00:00

abstract：:In summary, the complement system has evolved an important function in regulation of humoral immunity to T-dependent antigens. Covalent attachment of activated C3 to antigen alters its fate by enhancing uptake on the surface of FDC via CD21/CD35; and by enhancing signal transduction via the B cell coreceptor CD21/CD19...

journal_title：Current topics in microbiology and immunology

authors： Carroll M

更新日期：1999-01-01 00:00:00

abstract：:Bacterial polysaccharides play an essential role in cell viability, virulence, and evasion of host defenses. Although the polysaccharides themselves are highly diverse, the pathways by which bacteria synthesize these essential polymers are conserved in both Gram-negative and Gram-positive organisms. By utilizing a lip...

journal_title：Current topics in microbiology and immunology

authors： Taylor VL,Huszczynski SM,Lam JS

更新日期：2017-01-01 00:00:00

abstract：:Climate change adds complexity and uncertainty to human health issues such as emerging infectious diseases, food security, and national sustainability planning that intensify the importance of interdisciplinary and collaborative research. Collaboration between veterinary, medical, and public health professionals to un...

journal_title：Current topics in microbiology and immunology

authors： Patz JA,Hahn MB

更新日期：2013-01-01 00:00:00

abstract：:NF-κB is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. The activity of NF-κB is tightly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase, which phosphorylates...

journal_title：Current topics in microbiology and immunology

authors： Sun SC,Cesarman E

更新日期：2011-01-01 00:00:00

abstract：:The increased risk for severe dengue disease during secondary dengue virus (DENV) infections, along with the clinical and pathological evidence pointing to cytokines as the proximal mediators of disease, has interested cellular immunologists in exploring the role of DENV-specific T lymphocytes in the pathogenesis of d...

journal_title：Current topics in microbiology and immunology

authors： Rothman AL

更新日期：2010-01-01 00:00:00

abstract：:Recent advances in inductively coupled plasma mass spectrometry (ICP-MS) as applied in mass cytometry, enabled its broad applicability to life science research. Mass cytometry enables the high-dimensional characterization of cellular systems by simultaneously measuring dozens of metal isotope reporter labeled antibodi...

journal_title：Current topics in microbiology and immunology

authors： Zivanovic N,Jacobs A,Bodenmiller B

更新日期：2014-01-01 00:00:00

abstract：:Poxviruses have been long regarded as potent inhibitors of apoptotic cell death. More recently, they have been shown to inhibit necroptotic cell death through two distinct strategies. These strategies involve either blocking virus sensing by the host pattern recognition receptor, ZBP1 (also called DAI) or by influenci...

journal_title：Current topics in microbiology and immunology

authors： Koehler HS,Jacobs BL

更新日期：2021-01-29 00:00:00

abstract：:Recombinant protein- and peptide-based vaccines can deliver large amounts of specific antigens for tailored immune responses. One class of these are protein and peptide nanoclusters (PNCs), which are made entirely from the crosslinked antigen. PNCs leverage the inherent immunogenicity of nanoparticulate antigens while...

journal_title：Current topics in microbiology and immunology

authors： Chang TZ,Champion JA

更新日期：2020-11-10 00:00:00

abstract：:Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompany...

journal_title：Current topics in microbiology and immunology

authors： Owens T

更新日期：2009-01-01 00:00:00

abstract：:DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the ho...

journal_title：Current topics in microbiology and immunology

authors： Zawilak-Pawlik A,Zakrzewska-Czerwińska J

更新日期：2017-01-01 00:00:00

abstract：:Our knowledge of the organization and regulation of the murine hematopoietic stem cell hierarchy has, in large measure, been the result of the development of in vivo reconstitution assays for cells of various levels of differentiation. For example, many basic stem cell concepts were established using CFU-S as a paradi...

journal_title：Current topics in microbiology and immunology

authors： Dick JE

更新日期：1989-01-01 00:00:00

abstract：:The prototypes of the human MYC and RAF gene families are orthologs of animal proto-oncogenes that were originally identified as transduced alleles in the genomes of highly oncogenic retroviruses. MYC and RAF genes are now established as key regulatory elements in normal cellular physiology, but also as major cancer d...

journal_title：Current topics in microbiology and immunology

authors： Stefan E,Bister K

更新日期：2017-01-01 00:00:00

abstract：:Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary g...

journal_title：Current topics in microbiology and immunology

authors： Connor J,Kobinger G,Olinger G

更新日期：2017-01-01 00:00:00