Abstract：
:Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. Recent studies indicate the TOR (target of rapamycin) kinase acts within an intracellular regulatory network used by eukaryotic cells to regulate their growth according to nutrient availability. This network affects all aspects of gene expression, including transcription, translation, and protein stability, making TOR an excellent candidate as a global regulator of cellular activity. Here we review our recent studies of two specific transcriptional outputs controlled by TOR in the budding yeast, S. cerevisiae: (1) positive regulation of genes involved in ribosome biogenesis, and (2) negative regulation of genes required for de novo biosynthesis of glutamate and glutamine. These studies have raised the important issue as to how diverse nutritional cues can pass through a common signaling pathway and yet ultimately generate distinct transcriptional responses.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Powers T,Dilova I,Chen CY,Wedaman Kdoi
10.1007/978-3-642-18930-2_3subject
Has Abstractpub_date
2004-01-01 00:00:00pages
39-51eissn
0070-217Xissn
2196-9965journal_volume
279pub_type
杂志文章,评审abstract：:There is currently a handful of genome sequences available for tailed bacteriophages with genomes of more than 200 kbp of DNA, designated here as giant or jumbo phages. The majority of the proteins predicted from the genome sequences of these phages have no matches in the current sequence databases, and the genomes th...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-68618-7_7
更新日期：2009-01-01 00:00:00
abstract：:The genetic differences that potentially account for the attenuation of the Oka vaccine VZV preparation are more clearly defined than for perhaps any other vaccine in current use. This is due in large part to the small number of differences between the vaccine and the parental strain from which it was derived, and to ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2010_14
更新日期：2010-01-01 00:00:00
abstract：:Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts. While most evidence still supports this dogma, recent studies in bats have suggested other reservoir species may also exist. Extensive ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2014_396
更新日期：2014-01-01 00:00:00
abstract：:CVB3 myocarditis can lead to dilated cardiomyopath (DCM). DCM is one of the leading causes of the need for heart transplantation, so it is important to understand the life cycle of CVB3 and its interactions with the host cell. Infection causes rapid death of host cardiomyocytes by altering normal cellular homeostasis ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-75546-3_8
更新日期：2008-01-01 00:00:00
abstract：:Various gram-negative pathogens express type IV secretion systems (T4SSs) which translocate bacterial virulence factors into host target cells to hijack cellular processes for their own benefit and causing disease. The pathology of Helicobacter pylori, the causative agent of chronic gastritis, peptic ulcer disease, an...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-75241-9_8
更新日期：2017-01-01 00:00:00
abstract：:Recent advances in inductively coupled plasma mass spectrometry (ICP-MS) as applied in mass cytometry, enabled its broad applicability to life science research. Mass cytometry enables the high-dimensional characterization of cellular systems by simultaneously measuring dozens of metal isotope reporter labeled antibodi...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
doi：10.1007/82_2013_335
更新日期：2014-01-01 00:00:00
abstract：:The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-presenting cells in the priming of antiviral immunity. The confinement of HPV infection to epithelia puts the epit...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-06508-2_10
更新日期：2003-01-01 00:00:00
abstract：:Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine available. The development of safe GAS vaccines is challenging, researchers are confronted with obstacles such as the occurrence of many unique serotypes (there are greater than 150 M types), antigenic variation within the same serotype,...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2012_284
更新日期：2013-01-01 00:00:00
abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Our understanding of the mechanisms involved in the formation of the complex arrangement of neurons and their interconnections within the brain has made significant progress in recent years. Current research has uncovered a network of intracellular signaling events that provide precise coordination of a diverse array ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2010_82
更新日期：2010-01-01 00:00:00
abstract：:During the last two decades, researchers have developed robust systems for recombinant subunit vaccine production in plants. Stably and transiently transformed plants have particular advantages that enable immunization of humans and animals via mucosal delivery. The initial goal to immunize orally by ingestion of plan...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2011_158
更新日期：2012-01-01 00:00:00
abstract：:Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. I...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2017_23
更新日期：2017-01-01 00:00:00
abstract：:The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-55701-9_5
更新日期：2003-01-01 00:00:00
abstract：:Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
doi：10.1007/82_2016_16
更新日期：2017-01-01 00:00:00
abstract：:Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiate...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-59430-4_10
更新日期：2002-01-01 00:00:00
abstract：:Phospholipases are diverse enzymes produced in eukaryotic hosts and their bacterial pathogens. Several pathogen phospholipases have been identified as major virulence factors acting mainly in two different modes: on the one hand, they have the capability to destroy host membranes and on the other hand they are able to...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2013_348
更新日期：2013-01-01 00:00:00
abstract：:HAM/TSP is a chronic inflammatory disease of the spinal cord. It is rather rare in HTLV-1-infected individuals. Immunogenetic factors of the HLA complex have been identified that support or prevent the development of the disease. In HAM/TSP patients a characteristic constellation of high proviral loads and increased c...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-09525-6_10
更新日期：2002-01-01 00:00:00
abstract：:Climate change adds complexity and uncertainty to human health issues such as emerging infectious diseases, food security, and national sustainability planning that intensify the importance of interdisciplinary and collaborative research. Collaboration between veterinary, medical, and public health professionals to un...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2012_274
更新日期：2013-01-01 00:00:00
abstract：:The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth muscle cells are the predominant targets for virus ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-77349-8_4
更新日期：2008-01-01 00:00:00
abstract：:Epstein-Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with spec...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-22834-1_1
更新日期：2015-01-01 00:00:00
abstract：:Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that mol...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章
doi：10.1007/82_2018_146
更新日期：2019-01-01 00:00:00
abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-70617-5_9
更新日期：2009-01-01 00:00:00
abstract：:DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the ho...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-50520-6_4
更新日期：2017-01-01 00:00:00
abstract：:Xenotransplantation is a public health concern because it has the potential to infect human recipients with zoonotic and other infectious agents that are not endemic in human populations, thereby potentially introducing new infections to the human community. From this perspective, xenotransplantation clinical trials c...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-55541-1_2
更新日期：2003-01-01 00:00:00
abstract：:Microbial biofilms are governed by an intricate interplay between physical-chemical factors and the physiological and genetic properties of the inhabiting microbes. Many of the physiological traits that are exhibited in a biofilm environment have been observed and studied previously in detail in planktonic cultures. H...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-75418-3_2
更新日期：2008-01-01 00:00:00
abstract：:The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely thos...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/3-540-32952-8_8
更新日期：2006-01-01 00:00:00
abstract：:This review will focus on the principal clinical and pathophysiological features of the anaemia of falciparum malaria, including the problems of treating malarial anaemia, and also will suggest how recent advances in genomics may help our understanding of cellular and molecular mechanisms underlying this syndrome. ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/3-540-29088-5_6
更新日期：2005-01-01 00:00:00
abstract：:Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompany...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-00549-7_6
更新日期：2009-01-01 00:00:00
abstract：:The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the ...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2014_412
更新日期：2015-01-01 00:00:00
abstract：:By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the m...
journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/82_2015_483
更新日期：2016-01-01 00:00:00
