Abstract：
:The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids. Ten years ago, a family of cellular enzymes was first described with several proving capable of deaminating DNA and inhibiting HIV-1 replication. Ensuing studies on the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) restriction factors have uncovered a broad-spectrum innate defense network that suppresses the replication of numerous endogenous and exogenous DNA-based parasites. Although many viruses possess equally elaborate counter-defense mechanisms, the APOBEC3 enzymes offer a tantalizing possibility of leveraging innate immunity to fend off viral infection. Here, we focus on mechanisms of retroelement restriction by the APOBEC3 family of restriction enzymes, and we consider the therapeutic benefits, as well as the possible pathological consequences, of arming cells with active DNA deaminases.
journal_name
Curr Top Microbiol Immunoljournal_title
Current topics in microbiology and immunologyauthors
Refsland EW,Harris RSdoi
10.1007/978-3-642-37765-5_1subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1-27eissn
0070-217Xissn
2196-9965journal_volume
371pub_type
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
doi：10.1007/978-3-540-70962-6_3
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 历史文章,杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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journal_title：Current topics in microbiology and immunology
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Current topics in microbiology and immunology
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