Familial hydatidiform molar pregnancy: the germline imprinting defect hypothesis?

abstract：:Remarkable progress has been made in reducing measles incidence and mortality as a consequence of implementing the measles mortality reduction strategy of the World Health Organization (WHO) and United Nations Children's Fund (UNICEF). The revised global measles mortality reduction goal set forth in the WHO-UNICEF Glo...

journal_title：Current topics in microbiology and immunology

authors： Moss WJ

更新日期：2009-01-01 00:00:00

abstract：:The genetic differences that potentially account for the attenuation of the Oka vaccine VZV preparation are more clearly defined than for perhaps any other vaccine in current use. This is due in large part to the small number of differences between the vaccine and the parental strain from which it was derived, and to ...

journal_title：Current topics in microbiology and immunology

authors： Schmid DS

更新日期：2010-01-01 00:00:00

abstract：:The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the ...

journal_title：Current topics in microbiology and immunology

authors： Dash P,Thomas PG

更新日期：2015-01-01 00:00:00

abstract：:Animal models of ricin toxicosis are necessary for testing the efficacy of therapeutic measures, as well studying the mechanisms by which ricin exerts its toxicity in intact animals. Because ricin can serve as a particularly well-characterized model of tissue damage, and the host response to that damage, studies of th...

journal_title：Current topics in microbiology and immunology

authors： Roy CJ,Song K,Sivasubramani SK,Gardner DJ,Pincus SH

更新日期：2012-01-01 00:00:00

abstract：:Epstein-Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with spec...

journal_title：Current topics in microbiology and immunology

authors： Frappier L

更新日期：2015-01-01 00:00:00

abstract：:Tumor DNA contains valuable clues about the origin and pathogenesis of human cancers. Alterations in DNA methylation can lead to silencing of genes associated with distinct tumorigenic pathways. These pathway-specific DNA methylation changes help define tumor-specific DNA methylation profiles that can be used to furth...

journal_title：Current topics in microbiology and immunology

authors： Campan M,Weisenberger DJ,Laird PW

更新日期：2006-01-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiate...

journal_title：Current topics in microbiology and immunology

authors： Takeuchi O,Akira S

更新日期：2002-01-01 00:00:00

abstract：:The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mit...

journal_title：Current topics in microbiology and immunology

authors： Wilson BA,Ho M

更新日期：2012-01-01 00:00:00

abstract：:SIV-PBj14 is atypical for a lentivirus in that infection of pig-tailed macaques usually does not result in long-term progressive disease; however, this model may potentially provide valuable information about the pathogenesis of HIV and the development of AIDS. By capitalizing on some of the unique properties of the v...

journal_title：Current topics in microbiology and immunology

authors： Fultz PN

更新日期：1994-01-01 00:00:00

abstract：:Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...

journal_title：Current topics in microbiology and immunology

authors： Mori Y,Sadaoka T

更新日期：2010-01-01 00:00:00

abstract：:Phospholipases are diverse enzymes produced in eukaryotic hosts and their bacterial pathogens. Several pathogen phospholipases have been identified as major virulence factors acting mainly in two different modes: on the one hand, they have the capability to destroy host membranes and on the other hand they are able to...

journal_title：Current topics in microbiology and immunology

authors： Kuhle K,Flieger A

更新日期：2013-01-01 00:00:00

abstract：:Mammalian orthoreoviruses (reoviruses) are prototype members of the Reoviridae family of nonenveloped viruses. Reoviruses contain ten double-stranded RNA gene segments enclosed in two concentric protein shells, outer capsid and core. These viruses serve as a versatile experimental system for studies of virus cell entr...

journal_title：Current topics in microbiology and immunology

authors： Danthi P,Guglielmi KM,Kirchner E,Mainou B,Stehle T,Dermody TS

更新日期：2010-01-01 00:00:00

abstract：:The surface membrane molecule CD5 is expressed on mature T cells and on the B-1a subpopulation of B cells. These CD5 positive B cells express an antibody repertoire with a relatively high frequency of self-reactivity. There is uncertainty about the origins of CD5 B cells and the reasons for this are reviewed. Recent r...

journal_title：Current topics in microbiology and immunology

authors： Bandyopadhyay RS,Teutsch MR,Wortis HH

更新日期：1995-01-01 00:00:00

abstract：:The possibility that a new form of human prion disease, variant Creutzfeldt-Jakob disease (vCJD) had occurred in the UK was first raised by the identification of a small number of cases with unusual clinical characteristics. Atypical features included a young age at death, a predominantly psychiatric presentation, a r...

journal_title：Current topics in microbiology and immunology

authors： Will RG,Ward HJ

更新日期：2004-01-01 00:00:00

abstract：:NF-κB is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. The activity of NF-κB is tightly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase, which phosphorylates...

journal_title：Current topics in microbiology and immunology

authors： Sun SC,Cesarman E

更新日期：2011-01-01 00:00:00

abstract：:This study examines the adjuvant properties of silicone oil, silicone gel and silicone elastomer using a foreign antigen, bovine serum albumin (BSA). Seventy male Harlan Sprague-Dawley rats, approximately 250 grams each, were divided into 7 groups: A- incomplete Freund's adjuvant (IFA) with BSA; B- silicone oil with B...

journal_title：Current topics in microbiology and immunology

authors： Hill SL,Landavere MG,Rose NR

更新日期：1996-01-01 00:00:00

abstract：:The global need for a pandemic influenza vaccine is large. High-income countries have stated their intent to provide universal access for pandemic influenza vaccine to their populations. Assuming that a two-dose schedule would be needed, providing universal coverage globally would represent approximately 6.5 billion t...

journal_title：Current topics in microbiology and immunology

authors： Edwards KM,Sabow A,Pasternak A,Boslego JW

更新日期：2009-01-01 00:00:00

abstract：:Primary varicella-zoster virus (VZV) infection (varicella) induces VZV-specific antibody and VZV-specific T cell-mediated immunity. T cell-mediated immunity, which is detected within 1-2 weeks after appearance of rash, and consists of both CD4 and CD8 effector and memory T cells, is essential for recovery from varicel...

journal_title：Current topics in microbiology and immunology

authors： Weinberg A,Levin MJ

更新日期：2010-01-01 00:00:00

abstract：:Clostridium difficile causes infectious diarrhoea in humans and animals. It has been found in both diarrhoeal and non-diarrhoeal pigs, horses and cattle, suggesting a potential reservoir for human insection, and in 20-40 % of meat products in Canada and the USA, suggesting the possibility, albeit not proven, of food-b...

journal_title：Current topics in microbiology and immunology

authors： Squire MM,Riley TV

更新日期：2013-01-01 00:00:00

abstract：:Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches...

journal_title：Current topics in microbiology and immunology

authors： Wagner N,Atsmon-Raz Y,Ashkenasy G

更新日期：2016-01-01 00:00:00

abstract：:This chapter highlights the cholera situation in South Asia and the Bay of Bengal region, the original 'homeland' of cholera. A detailed discussion of cholera outbreaks in individual countries in South-East Asia follows. The countries of the World Health Organization (WHO) SEARO (South-East Asia Region) region are dis...

journal_title：Current topics in microbiology and immunology

authors： Bharati K,Bhattacharya SK

更新日期：2014-01-01 00:00:00

abstract：:Hemopoietic cells express relatively high levels of the type I phosphoinositide (PI) 3-kinase isoforms, with p110δ and γ exhibiting specialized signaling functions in neutrophils, monocytes, mast cells, and lymphocytes. In platelets, p110β appears to be the dominant PI 3-kinase isoform regulating platelet activation, ...

journal_title：Current topics in microbiology and immunology

authors： Jackson SP,Schoenwaelder SM

更新日期：2010-01-01 00:00:00

abstract：:Ischemic cardiomyopathy leading to congestive heart failure remains the leading source of morbidity and mortality in Western society and medical management of this condition offers only palliative treatment. While allogeneic heart transplantation can both extend and improve the quality of life for patients with end-st...

journal_title：Current topics in microbiology and immunology

authors： Krupnick AS,Kreisel D,Riha M,Balsara KR,Rosengard BR

更新日期：2004-01-01 00:00:00

abstract：:Influenza hemagglutinin (HA) is the major surface glycoprotein on influenza viruses and mediates viral attachment and subsequent fusion with host cells. The HA is the major target of the immune response, but due to its high level of variability, as evidenced by substantial antigenic diversity, it had been historically...

journal_title：Current topics in microbiology and immunology

authors： Lee PS,Wilson IA

更新日期：2015-01-01 00:00:00

abstract：:Production of type I IFN is the key response to viral infection. Since the discovery of type I IFNs in 1957, long double-stranded RNA formed during replication of many viruses was thought to be responsible for type I IFN induction, and for decades double-stranded RNA-activated protein kinase (PKR) was thought to be th...

journal_title：Current topics in microbiology and immunology

authors： Schlee M,Barchet W,Hornung V,Hartmann G

更新日期：2007-01-01 00:00:00

abstract：:It has been estimated that there are more microorganisms within and upon the human body than there are human cells. By necessity, every accessible niche must be defended by innate mechanisms to prevent invasive infection, and ideally that precludes the need for robust inflammatory responses. Yet the potential for path...

journal_title：Current topics in microbiology and immunology

authors： Yeaman MR,Bayer AS

更新日期：2006-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has evolved numerous strategies to commandeer the host cell for producing viral progeny. The virus manipulates host cell cycle pathways from the early stages of infection to stimulate viral DNA replication at the expense of cellular DNA synthesis. At the same time, cell cycle checkpoints a...

journal_title：Current topics in microbiology and immunology

authors： Sanchez V,Spector DH

更新日期：2008-01-01 00:00:00

abstract：:Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is hig...

journal_title：Current topics in microbiology and immunology

authors： Habenstein B,El Mammeri N,Tolchard J,Lamon G,Tawani A,Berbon M,Loquet A

更新日期：2020-01-01 00:00:00

abstract：:The accumulation of protein aggregates has a fundamental role in the patophysiology of distinct neurodegenerative diseases. This phenomenon may have a common origin, where disruption of intracellular mechanisms related to protein homeostasis (here termed proteostasis) control during aging may result in abnormal protei...

journal_title：Current topics in microbiology and immunology

authors： Cabral-Miranda F,Hetz C

更新日期：2018-01-01 00:00:00

abstract：:Picornavirus 5' NCRs contain IRES elements that have been divided into two groups, exemplified by PV (type 1) and EMCV (type 2). These elements are functionally related and have an intriguing level of structural and sequence similarity. Some conserved RNA sequences and/or structures may correspond to cis-acting elemen...

journal_title：Current topics in microbiology and immunology

authors： Hellen CU,Wimmer E

更新日期：1995-01-01 00:00:00