Cholera outbreaks in South-East Asia.

abstract：:Yersinia entercolitica and Yersinia pseudotuberculosis are human foodborne pathogens that interact extensively with tissues of the gut and the host's immune system to cause disease. As part of their pathogenic strategies, the Yersinia have evolved numerous ways to invade host tissues, gain essential nutrients, and eva...

journal_title：Current topics in microbiology and immunology

authors： Dube P

更新日期：2009-01-01 00:00:00

abstract：:The activation and expansion of T cells in an antimicrobial immune response is based on the ability of T cell receptors (TCR) to discriminate between MHC-bound peptides derived from different microbial agents as well as self-proteins. However, the specificity of T cells is constrained by the limited number of peptide ...

journal_title：Current topics in microbiology and immunology

authors： Wucherpfennig KW

更新日期：2005-01-01 00:00:00

abstract：:The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments includ...

journal_title：Current topics in microbiology and immunology

authors： Hendriks A,Cruz AR,Soldaini E,Manetti AGO,Bagnoli F

更新日期：2018-09-20 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor alpha (RARa) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARalpha fuses to the PML gene in the majority of APL cases, and in a few...

journal_title：Current topics in microbiology and immunology

authors： Scaglioni PP,Pandolfi PP

更新日期：2007-01-01 00:00:00

abstract：:An account is given of the experiences and events which led to a search being undertaken for a causative virus in the recently described Burkitt's lymphoma and of the steps which ultimately culminated in the discovery of the new human herpesvirus which came to be known as Epstein-Barr virus (EBV). ...

journal_title：Current topics in microbiology and immunology

authors： Epstein A

更新日期：2015-01-01 00:00:00

abstract：:Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster vi...

journal_title：Current topics in microbiology and immunology

authors： Mori Y,Sadaoka T

更新日期：2010-01-01 00:00:00

abstract：:Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine available. The development of safe GAS vaccines is challenging, researchers are confronted with obstacles such as the occurrence of many unique serotypes (there are greater than 150 M types), antigenic variation within the same serotype,...

journal_title：Current topics in microbiology and immunology

authors： Henningham A,Gillen CM,Walker MJ

更新日期：2013-01-01 00:00:00

abstract：:Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts. While most evidence still supports this dogma, recent studies in bats have suggested other reservoir species may also exist. Extensive ...

journal_title：Current topics in microbiology and immunology

authors： Yoon SW,Webby RJ,Webster RG

更新日期：2014-01-01 00:00:00

abstract：:Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermo...

journal_title：Current topics in microbiology and immunology

authors： Horiguchi Y

更新日期：2012-01-01 00:00:00

abstract：:Ischemic cardiomyopathy leading to congestive heart failure remains the leading source of morbidity and mortality in Western society and medical management of this condition offers only palliative treatment. While allogeneic heart transplantation can both extend and improve the quality of life for patients with end-st...

journal_title：Current topics in microbiology and immunology

authors： Krupnick AS,Kreisel D,Riha M,Balsara KR,Rosengard BR

更新日期：2004-01-01 00:00:00

abstract：:Promoting remyelination following injury to the central nervous system (CNS) promises to be an effective neuroprotective strategy to limit the loss of surviving axons and prevent disability. Studies confirm that multiple sclerosis (MS) and spinal cord injury lesions contain myelinating cells and their progenitors. Rec...

journal_title：Current topics in microbiology and immunology

authors： Warrington AE,Rodriguez M

更新日期：2008-01-01 00:00:00

abstract：:DNA replication is an important step in the life cycle of every cell that ensures the continuous flow of genetic information from one generation to the next. In all organisms, chromosome replication must be coordinated with overall cell growth. Helicobacter pylori growth strongly depends on its interaction with the ho...

journal_title：Current topics in microbiology and immunology

authors： Zawilak-Pawlik A,Zakrzewska-Czerwińska J

更新日期：2017-01-01 00:00:00

abstract：:Natural BD is a nonpurulent acute/subacute encephalitis of horses and sheep with a propensity to involve the olfactory and limbic systems, and the brain stem. The inflammation is concentrated primarily in the gray matter, but subcortical white matter may also be affected. Experimental BD can be produced in a series of...

journal_title：Current topics in microbiology and immunology

authors： Gosztonyi G,Ludwig H

更新日期：1995-01-01 00:00:00

abstract：:Collective knowledge regarding the occurrence of influenza among swine is incomplete due to inconsistent surveillance of swine populations. In this chapter, we review what surveillance activities exist and some of the practical challenges encountered. Furthermore, to support robust surveillance activities, accurate la...

journal_title：Current topics in microbiology and immunology

authors： Detmer S,Gramer M,Goyal S,Torremorell M,Torrison J

更新日期：2013-01-01 00:00:00

abstract：:The increased risk for severe dengue disease during secondary dengue virus (DENV) infections, along with the clinical and pathological evidence pointing to cytokines as the proximal mediators of disease, has interested cellular immunologists in exploring the role of DENV-specific T lymphocytes in the pathogenesis of d...

journal_title：Current topics in microbiology and immunology

authors： Rothman AL

更新日期：2010-01-01 00:00:00

abstract：:Molecular mimics of self-antigens can behave as altered peptide ligands and serve to ameliorate autoimmune disease. Analysis of experimental autoimmune encephalomyelitis with proteomic autoantibody microarrays reveals that there might exist a wide variety of microbes with features that mimic self-epitopes. Autoimmunit...

journal_title：Current topics in microbiology and immunology

authors： Steinman L,Utz PJ,Robinson WH

更新日期：2005-01-01 00:00:00

abstract：:By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the m...

journal_title：Current topics in microbiology and immunology

authors： Bordería AV,Rozen-Gagnon K,Vignuzzi M

更新日期：2016-01-01 00:00:00

abstract：:Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the ...

journal_title：Current topics in microbiology and immunology

authors： Niedermann G

更新日期：2002-01-01 00:00:00

abstract：:As the largest RNA virus, coronavirus replication employs complex mechanisms and involves various viral and cellular proteins. The first open reading frame of the coronavirus genome encodes a large polyprotein, which is processed into a number of viral proteins required for viral replication directly or indirectly. Th...

journal_title：Current topics in microbiology and immunology

authors： Shi ST,Lai MM

更新日期：2005-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is a cellular organelle responsible for folding of secretory and membrane proteins. Perturbance in ER homeostasis caused by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defens...

journal_title：Current topics in microbiology and immunology

authors： Chandrahas VK,Han J,Kaufman RJ

更新日期：2018-01-01 00:00:00

abstract：:After infection of a cell, the positive-strand RNA genome of Hepatitis C Virus (HCV) directly serves as the template for translation in the cytosol. By the use of an internal ribosome entry site (IRES) element in the 5'-untranslated region (5'-UTR) of the viral RNA, the HCV RNA bypasses the need for nuclear processing...

journal_title：Current topics in microbiology and immunology

authors： Niepmann M

更新日期：2013-01-01 00:00:00

abstract：:Influenza hemagglutinin (HA) is the major surface glycoprotein on influenza viruses and mediates viral attachment and subsequent fusion with host cells. The HA is the major target of the immune response, but due to its high level of variability, as evidenced by substantial antigenic diversity, it had been historically...

journal_title：Current topics in microbiology and immunology

authors： Lee PS,Wilson IA

更新日期：2015-01-01 00:00:00

abstract：:A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has...

journal_title：Current topics in microbiology and immunology

authors： Mouchess ML,Anderson M

更新日期：2014-01-01 00:00:00

abstract：:The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely thos...

journal_title：Current topics in microbiology and immunology

authors： Pirity M,Blanck JK,Schreiber-Agus N

更新日期：2006-01-01 00:00:00

abstract：:HAM/TSP is a chronic inflammatory disease of the spinal cord. It is rather rare in HTLV-1-infected individuals. Immunogenetic factors of the HLA complex have been identified that support or prevent the development of the disease. In HAM/TSP patients a characteristic constellation of high proviral loads and increased c...

journal_title：Current topics in microbiology and immunology

authors： Kitze B,Usuku K

更新日期：2002-01-01 00:00:00

abstract：:Commercial vaccines currently available against swine influenza virus (SIV) are inactivated, adjuvanted, whole virus vaccines, based on H1N1 and/or H3N2 and/or H1N2 SIVs. In keeping with the antigenic and genetic differences between SIVs circulating in Europe and the US, the vaccines for each region are produced local...

journal_title：Current topics in microbiology and immunology

authors： Van Reeth K,Ma W

更新日期：2013-01-01 00:00:00

abstract：:Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiate...

journal_title：Current topics in microbiology and immunology

authors： Takeuchi O,Akira S

更新日期：2002-01-01 00:00:00

abstract：:A number of Gram-positive bacteria are important players in industry as producers of a diverse array of economically interesting metabolites and proteins. As discussed in this overview, several Gram-positive bacteria are valuable hosts for the production of heterologous proteins. In contrast to Gram-negative bacteria,...

journal_title：Current topics in microbiology and immunology

authors： Anné J,Economou A,Bernaerts K

更新日期：2017-01-01 00:00:00

abstract：:The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways u...

journal_title：Current topics in microbiology and immunology

authors： Böhm S,Kao D,Nimmerjahn F

更新日期：2014-01-01 00:00:00

abstract：:Hendra virus, a novel and fatally zoonotic member of the family Paramyxoviridae, was first described in Australia in 1994. Periodic spillover from its natural host (fruit bats) results in catastrophic disease in horses and occasionally the subsequent infection of humans. Prior to 2011, 14 equine incidents involving se...

journal_title：Current topics in microbiology and immunology

authors： Field H,Crameri G,Kung NY,Wang LF

更新日期：2012-01-01 00:00:00